Pulmonary coagulopathy: A potential therapeutic target in different forms of lung injury

Thorax

Volumn 62, Issue 7, 2007, Pages 563-564

  Schultz, Marcus J ^a,b   Levi, Marcel ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT RESPIRATORY DISTRESS SYNDROME; BLOOD CLOTTING DISORDER; EDITORIAL; LUNG ALVEOLUS EPITHELIUM; LUNG EDEMA; LUNG INFECTION; LUNG INJURY; PNEUMONIA; PRIORITY JOURNAL;

BLOOD COAGULATION DISORDERS; HUMANS; LUNG; LUNG DISEASES; RESPIRATION, ARTIFICIAL;

EID: 34447321047     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.2006.067256     Document Type: Editorial

References (30)

1. Levi M, Ten Cate H. Disseminated intravascular coagulation. N Engl J Med 1999;341:586-92.
2. Levi M, ten Cate H, Bauer KA, et al. Inhibition of endotoxin-induced activation of coagulation and fibrinolysis by pentoxifylline or by a monoclonal anti-tissue factor antibody in chimpanzees. J Clin Invest 1994;93:114-20.
3. Giesen PL, Rauch U, Bohrmann B, et al. Blood-borne tissue factor: another view of thrombosis. Proc Natl Acad Sci USA 1999;96:2311-5.
4. Bernard GR, Vincent JL, Laterre PF, et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001;344:699-709.
5. Gunther A, Mosavi P, Heinemann S, et al. Alveolar fibrin formation caused by enhanced procoagulant and depressed fibrinolytic capacities in severe pneumonia. Comparison with the acute respiratory distress syndrome. Am J Respir Crit Care Med 2000;161:454-62.
6. Fuchs-Buder T, de Moerloose P, Ricou B, et al. Time course of procoagulant activity and D dimer in bronchoalveolar fluid of patients at risk for or with acute respiratory distress syndrome. Am J Respir Crit Care Med 1996;153:163-7.
7. Idell S, Gonzalez K, Bradford H, et al. Procoagulant activity in bronchoalveolar lavage in the adult respiratory distress syndrome. Contribution of tissue factor associated with factor VII. Am Rev Respir Dis 1987;136:1466-74.
8. Idell S, Koenig KB, Fair DS, et al. Serial abnormalities of fibrin turnover in evolving adult respiratory distress syndrome. Am J Physiol 1991;261:L240-8.
9. Schultz MJ, Millo J, Levi M, et al. Local activation of coagulation and inhibition of fibrinolysis in the lung during ventilator associated pneumonia. Thorax 2004;59:130-5.
10. Miller DL, Welty-Wolf K, Carraway MS, et al. Extrinsic coagulation blockade attenuates lung injury and proinflammatory cytokine release after intratracheal lipopolysaccharide. Am J Respir Cell Mol Biol 2002;26:650-8.
11. Yamamoto K, Loskutoff DJ. Extrahepatic expression and regulation of protein C in the mouse. Am J Pathol 1998;153:547-55.
12. Choi G, Schultz MJ, Levi M, et al. Protein C in pneumonia. Thorax 2005;60:705-6.
13. Choi G, Bresser P, Levi M, et al. Disturbed alveolar fibrin turnover during pneumonia is associated with reduced activated protein C levels in lungs. Crit Care 2004;8(Suppl 1):111.
14. Hataji O, Taguchi O, Gabazza EC, et al. Activation of protein C pathway in the airways. Lung 2002;180:47-59.
15. Idell S. Endothelium and disordered fibrin turnover in the injured lung: newly recognized pathways. Crit Care Med 2002;30:S274-80.
16. Marshall BC, Sageser DS, Rao NV, et al. Alveolar epithelial cell plasminogen activator. Characterization and regulation. J Biol Chem 1990;265:8198-204.
17. Belperio JA, Keane MP, Burdick MD, et al. Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury. J Clin Invest 2002;110:1703-16.
18. Altemeier WA, Matute-Bello G, Frevert CW, et al. Mechanical ventilation with moderate tidal volumes synergistically increases lung cytokine response to systemic endotoxin. Am J Physiol Lung Cell Mol Physiol 2004;287:L533-42.
19. Dahlem P, Bos AP, Haitsma JJ, et al. Alveolar fibrinolytic capacity suppressed by injurious mechanical ventilation. Intensive Care Med 2005;31:724-32.
20. Dahlem P, Bos AO, Haitsma JJ, et al. Mechanical ventilation affects alveolar fibrinolysis in LPS-induced lung injury. Eur Respir J 2006;28:992-8.
21. Choi G, Wolthuis E, Bresser P, et al. Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents alveolar coagulation in patients without lung injury. Anesthesiology 2006;105:689-95.
22. Bastarache J, Wang L, Geiser T, et al. The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Thorax 2007;62:608-16.
23. Lyberg T, Nakstad B, Hetland O, et al. Procoagulant (thromboplastin) activity in human bronchoalveolar lavage fluids is derived from alveolar macrophages. Eur Respir J 1990;3:61-7.
24. Laterre P-F, Garber G, Levy H, et al. Severe community-acquired pneumonia as a cause of severe sepsis: data from the PROWESS study. Crit Care Med 2005;33:952-61.
25. van der Poll T, Levi M, Nick JA, et al. Activated protein C inhibits local coagulation after intrapulmonary delivery of endotoxin in humans. Am J Respir Crit Care Med 2005;171:1125-8.
26. Desai MH, Mlcak R, Richardson J, et al. Reduction in mortality in pediatric patients with inhalation injury with aerosolized heparin/N-acetylcystine [correction of acetylcystine] therapy. J Burn Care Rehabil 1998;19:210-2.
27. Brown M, Desai M, Traber LD, et al. Dimethylsulfoxide with heparin in the treatment of smoke inhalation injury. J Burn Care Rehabil 1988;9:22-5.
28. Cox CS Jr, Zwischenberger JB, Traber DL, et al. Heparin improves oxygenation and minimizes barotrauma after severe smoke inhalation in an ovine model. Surg Gynecol Obstet 1993;176:339-49.
29. Murakami K, McGuire R, Cox RA, et al. Heparin nebulization attenuates acute lung injury in sepsis following smoke inhalation in sheep. Shock 2002;18:236-41.
30. Saliba MJ Jr. The effects and uses of heparin in the care of burns that improves treatment and enhances the quality of life. Acta Chir Plast 1997;39:13-6.