Formulation design and development to produce orodispersible tablets by direct compression

Journal of Drug Delivery Science and Technology

Volumn 17, Issue 3, 2007, Pages 199-203

  Segale, L ^a   Maggi, L ^b   Ochoa Machiste, E ^b   Conti, S ^b   Conte, U ^b   Grenier, A ^c   Besse, C ^c  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

^c Antares Pharma AG   (Switzerland)

Author keywords

Direct compression; Disintegration time; Mannitol; Orodispersible tablets

Indexed keywords

ASPARTAME; C ASCEND TREHALOSE 16400; EUDRAGIT; EUDRAGIT L100 55; EXCIPIENT; GLUCIDEX IT19; ISOMALT; ISOMALT DC100; MAGNESIUM STEARATE; MALTISORB P200; MALTITOL; MALTODEXTRIN; MANNITOL; MELOXICAM; MICROCRYSTALLINE CELLULOSE; NONSTEROID ANTIINFLAMMATORY AGENT; PEARLITON 100SD; PEARLITON 200SD; POVIDONE; SILICON DIOXIDE; STARCH; SYLOID 244; TREHALOSE; UNCLASSIFIED DRUG; XYLITAB 200; XYLITOL;

ARTICLE; DRUG COATING; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; ORGANOLEPTIC PROPERTY; PARTICLE SIZE; POROSITY; TABLET COMPRESSION; TECHNOLOGY;

EID: 34447319103     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1773-2247(07)50036-5     Document Type: Article

References (24)

1. th Ed., Supplement 5.2, p. 3151, 2005.
2. Habib W., Khankari R., Hontz J. - Fast dissolve drug delivery systems.- Crit Rev Ther Drug Carrier Syst, 17, 31-72, 2000.
3. Brown D. - Orally disintegrating tablets: taste over speed. - Drug Deliv Technol, 3, 58-61, 2003.
4. Fu Y., Yang S., Jeong S.H., Kimura S., Park K. - Orally fast disintegrating tablets: development, technologies, taste-masking and clinical studies. - Crit Rev Ther Drug Carrier Syst, 21, 433-475, 2004.
5. Chang R.K., Guo X., Burnside B.A., Couch R.A. - Fast-dissolving tablets. - Pharm Technol, 24, 52-58, 2000.
6. Sastry S.V., Nyshadam J.R., Fix J.A. - Recent technological advances in oral drug delivery - a review. - PSTT, 3, 138-145, 2000.
7. Perissutti B., Rubessa F., Moneghini M., Voinovich D. - Formulation design of carbamazepine fast-release tablets prepared by melt-granulation technique. - Int J Pharm, 256, 53-63, 2003.
8. Seager H. - Drug-delivery products and the Zydis fast-dissolving dosage form. - J Pharm Pharmacol, 50, 375-382, 1998.
9. Van Houten B. - Breaking new ground. - Pharmaceutical and Medical Packaging News, 9, 2004.
10. Makino T., Yamada M., Kikuta J. - Fast dissolving tablet and its production. - US Patent 5,501,861, 1996.
11. Cousin G., Bruna E., Gendrot E. - Rapidly disintegratable multiparticular tablet. - US Patent 5,464,632, 1995.
12. Bi Y., Sunada H., Yonezawa Y., Danjo K., Otsuka A., Iida K. - Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity. - Chem Pharm Bull, 44, 2121-2127, 1996.
13. Schiermeier S., Schmidt C. - Fast dispersible ibuprofen tablets. - Eur J Pharm Sci, 15, 295-300, 2002.
14. Shu T., Suzuki H., Hironaka K., Ito K. - Studies of rapidly disintegrating tablets in the oral cavity using co-ground mixtures of mannitol with crospovidone. - Chem Pharm Bull, 50, 193-198, 2002.
15. Sunada H., Bi Y. - Preparation, evaluation and optimization of rapidly disintegrating tablets. - Powder Technol, 122, 188-198, 2002.
16. Dobetti L. - Fast disintegrating tablets. - US Patent 6,596,311, 2003.
17. Abu-Izza K.A., Li V.H., Look J.L., Parr G.D., Schineller M.K. - Fast dissolving tablet. - US Patent 6,733,781, 2004.
18. Rault I., Pionnier E. - Use of an acrylic type polymer as disintegrating agent. - US Patent 6,696,085, 2004.
19. Siepmann J., Kranz H., Peppas N.A., Bodmeier R. - Calculation of the required size and shape of hydroxypropylmethylcellulose matrices to achieved desired drug release profiles. - Int J Pharm, 201, 151-164, 2000.
20. Lorenzo-Lamosa M.L., Cuna M., Vila-Jato J.L., Torres D., Alonso M.J. - Development of a microencapsulated form of cefuroxime axetil using pH-sensitive acrylic polymers. - J Microencapsul, 14, 607-616, 1997.
21. Luppi B., Cerchiara T., Bigucci F., Orienti I., Zecchi V. - pH sensitive polymeric physical mixture for possible site-specific delivery of ibuprofen. - Eur J Pharm Biopharm, 55, 199-202, 2003.
22. Ceballos A., Cirri M., Maestrelli F., Corti G., Mura P. - Influence of formulation and process variables on in vitro release of theophylline from directly-compressed Eudragit matrix tablets. - Farmaco, 60, 913-918, 2005.
23. ICH Guideline. - Stability Testing of New drugs and Products. - Q1A (R), 2003.
24. Shangraw R., Mitrevej A., Shah M. - A new era of tablet disintegrants. - Pharm Technol, 4, 49-57, 1980.