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Volumn 70, Issue 1, 2007, Pages 40-46

Solid-phase synthesis of a peptide derivative of thymosin alpha1 and initial studies on its 99mTc-radiolabelling

Author keywords

99mTc chelating moiety; 99mTc radiolabelling; Fmoc solid phase peptide synthesis; Thymosin alpha1

Indexed keywords

5,6,7,13 TETRAHYDRO 12 (3 HYDROXYPROPYL) 9 ISOPROPOXYMETHYLINDENO[2,1 A]PYRROLO[3,4 C]CARBAZOL 5(12H) ONE DIMETHYLGLYCINE ESTER; AMINOCAPROIC ACID; CYSTEINE; LYSINE; PEPTIDE DERIVATIVE; RESIN; SERINE; TECHNETIUM 99M; THYMOSIN ALPHA1;

EID: 34447313177     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2007.00529.x     Document Type: Article
Times cited : (6)

References (30)
  • 1
    • 0018412317 scopus 로고
    • The chemistry and biology of thymosin
    • Low T.L.K., Goldstein A.L. (1979) The chemistry and biology of thymosin. J Biol Chem 254 : 987 995.
    • (1979) J Biol Chem , vol.254 , pp. 987-995
    • Low, T.L.K.1    Goldstein, A.L.2
  • 2
    • 0013945220 scopus 로고
    • Preparation, assay and partial purification of a thymic lymphocytopoietic factor (thymosin)
    • Goldstein A.L., Slater F.D., White A. (1966) Preparation, assay and partial purification of a thymic lymphocytopoietic factor (thymosin). Proc Natl Acad Sci U S A 56 : 1010 1017.
    • (1966) Proc Natl Acad Sci U S a , vol.56 , pp. 1010-1017
    • Goldstein, A.L.1    Slater, F.D.2    White, A.3
  • 3
    • 0021069943 scopus 로고
    • Immunomodulation of murine B16 melanoma metastasis: Thymosin, thymectomy and irradiation
    • Naylor P.H. (1983) Immunomodulation of murine B16 melanoma metastasis: thymosin, thymectomy and irradiation. Thymus 5 : 355 362.
    • (1983) Thymus , vol.5 , pp. 355-362
    • Naylor, P.H.1
  • 5
    • 16844383336 scopus 로고    scopus 로고
    • Comparison of assays for determination of peptide content for lyophilized thymalfasin
    • Vemuri S. (2005) Comparison of assays for determination of peptide content for lyophilized thymalfasin. J Pept Res 65 : 433 439.
    • (2005) J Pept Res , vol.65 , pp. 433-439
    • Vemuri, S.1
  • 6
    • 0036557949 scopus 로고    scopus 로고
    • Thymosin alpha 1. SciClone pharmaceuticals
    • Billich A. (2002) Thymosin alpha 1. SciClone pharmaceuticals. Curr Opin Invest Drugs 3 : 698 707.
    • (2002) Curr Opin Invest Drugs , vol.3 , pp. 698-707
    • Billich, A.1
  • 7
    • 0000095902 scopus 로고
    • Prothymosin alpha: Isolation and properties of the major immunoreactive form of thymosin alpha 1 in rat thymus
    • Haritos A.A., Goodall G.J., Horecker B.L. (1984) Prothymosin alpha: isolation and properties of the major immunoreactive form of thymosin alpha 1 in rat thymus. Proc Natl Acad Sci U S A 81 : 1008 1011.
    • (1984) Proc Natl Acad Sci U S a , vol.81 , pp. 1008-1011
    • Haritos, A.A.1    Goodall, G.J.2    Horecker, B.L.3
  • 9
    • 0041305878 scopus 로고    scopus 로고
    • The thymosins. Prothymosin alpha, parathymosin, and beta-thymosins: Structure and function
    • Hannappel E., Huff T. (2003) The thymosins. Prothymosin alpha, parathymosin, and beta-thymosins: structure and function. Vitam Horm 66 : 257 296.
    • (2003) Vitam Horm , vol.66 , pp. 257-296
    • Hannappel, E.1    Huff, T.2
  • 10
    • 22544483863 scopus 로고    scopus 로고
    • Prothymosin alpha receptor associates with lipid rafts in PHA-stimulated lymphocytes
    • Saldago F.J., Pineiro A., Canda-Sanchez A., Lojo J., Nogueira M. (2005) Prothymosin alpha receptor associates with lipid rafts in PHA-stimulated lymphocytes. Mol Membr Biol 22 : 163 176.
    • (2005) Mol Membr Biol , vol.22 , pp. 163-176
    • Saldago, F.J.1    Pineiro, A.2    Canda-Sanchez, A.3    Lojo, J.4    Nogueira, M.5
  • 12
    • 22544486256 scopus 로고    scopus 로고
    • PTHrP fragments 1-16 and 1-23 do not bind to either the ETA or the ETB endothelin receptors
    • Langlois C., Letourneau M., Turcotte K., Detheux M., Fournier A. (2005) PTHrP fragments 1-16 and 1-23 do not bind to either the ETA or the ETB endothelin receptors. Peptides 26 : 1436 1440.
    • (2005) Peptides , vol.26 , pp. 1436-1440
    • Langlois, C.1    Letourneau, M.2    Turcotte, K.3    Detheux, M.4    Fournier, A.5
  • 13
    • 33748216792 scopus 로고
    • Technetium radiopharmaceuticals - Fundamentals, synthesis, structure, and development
    • Schwochau K. (1994) Technetium radiopharmaceuticals - fundamentals, synthesis, structure, and development. Angew Chem Ed Engl 33 : 2258 2267.
    • (1994) Angew Chem Ed Engl , vol.33 , pp. 2258-2267
    • Schwochau, K.1
  • 14
    • 34447340845 scopus 로고
    • Requirements for binding assays - Tracer using radioisotopic labels
    • In: Burdon, R.H., van Knippenberg, P.H., editors. Amsterdam, New York, Oxford: Elsevier. p.
    • Chard T. (1987) Requirements for binding assays - tracer using radioisotopic labels. In : Burdon R.H., van Knippenberg P.H., editors. An Introduction to Radioimmunoassay and Related Techniques. Amsterdam, New York, Oxford : Elsevier p. 40 67.
    • (1987) An Introduction to Radioimmunoassay and Related Techniques. , pp. 40-67
    • Chard, T.1
  • 16
    • 13544251567 scopus 로고    scopus 로고
    • Accumulation of radiolabelled low molecular peptides and proteins in experimental inflammation
    • Komarek P., Kleisner I., Komarkova I., Konopkova M. (2005) Accumulation of radiolabelled low molecular peptides and proteins in experimental inflammation. Int J Pharm 291 : 119 125.
    • (2005) Int J Pharm , vol.291 , pp. 119-125
    • Komarek, P.1    Kleisner, I.2    Komarkova, I.3    Konopkova, M.4
  • 17
    • 0001743347 scopus 로고    scopus 로고
    • Rhenium (V) and technetium (V) oxo complexes of an N2N′S peptidic chelator: Evidence of interconversion between the syn and anti conformations
    • Wong E., Fauconnier T., Bennett S., Valliant J., Nguyen T., Lau F., Lu L.F.L., Pollak A., Bell R.A., Thornback J.R. (1997) Rhenium (V) and technetium (V) oxo complexes of an N2N′S peptidic chelator: evidence of interconversion between the syn and anti conformations. Inorg Chem 36 : 5799 5808.
    • (1997) Inorg Chem , vol.36 , pp. 5799-5808
    • Wong, E.1    Fauconnier, T.2    Bennett, S.3    Valliant, J.4    Nguyen, T.5    Lau, F.6    Lu, L.F.L.7    Pollak, A.8    Bell, R.A.9    Thornback, J.R.10
  • 18
    • 0028204040 scopus 로고
    • (R,S) 2-Fluoro (chloro)-4′-carboxy-triphenyl methanol. Novel acid labile trityl type handles for solid phase peptide synthesis
    • Zikos C.C., Ferderigos N.G. (1994) (R,S) 2-Fluoro (chloro)-4′- carboxy-triphenyl methanol. Novel acid labile trityl type handles for solid phase peptide synthesis. Tetrahedron Lett 35 : 1767 1768.
    • (1994) Tetrahedron Lett , vol.35 , pp. 1767-1768
    • Zikos, C.C.1    Ferderigos, N.G.2
  • 19
    • 0001454914 scopus 로고
    • Metal-carbonyl syntheses: 22. Low-pressure carbonylation of [MOCl(4)](-) and [MO4](-) - The technetium(I) and rhenium(I) complexes [NET(4)](2)[MCL(3)(CO) (3)]
    • Alberto R., Schibli R., Egli A., Schubiger A., Herrmann W.A., Artus G., Abram U., Kaden T. (1995) Metal-carbonyl syntheses: 22. Low-pressure carbonylation of [MOCl(4)](-) and [MO4](-) - the technetium(I) and rhenium(I) complexes [NET(4)](2)[MCL(3)(CO)(3)]. J Organomet Chem 492 : 217 224.
    • (1995) J Organomet Chem , vol.492 , pp. 217-224
    • Alberto, R.1    Schibli, R.2    Egli, A.3    Schubiger, A.4    Herrmann, W.A.5    Artus, G.6    Abram, U.7    Kaden, T.8
  • 20
    • 0019627519 scopus 로고
    • Quantitative monitoring of solid phase peptide synthesis by the ninhydrin reaction
    • Sarin V.K., Kent S.B.H., Tam J.P., Merrifield R.B. (1981) Quantitative monitoring of solid phase peptide synthesis by the ninhydrin reaction. Anal Biochem 117 : 147 157.
    • (1981) Anal Biochem , vol.117 , pp. 147-157
    • Sarin, V.K.1    Kent, S.B.H.2    Tam, J.P.3    Merrifield, R.B.4
  • 21
    • 0013558422 scopus 로고
    • Preparation and use of the 4-[1-[N-(9-fluorenylmethyloxycarbonyl)-amino]- 2-(trimethylsilyl)ethyl]phenoxy- acetic acid linkage agent for solid-phase synthesis of C-terminal peptide amides: Improved yields of tryptophan-containing peptides
    • Chao H.-G., Bernatowich M.S., Matsueda G.R. (1993) Preparation and use of the 4-[1-[N-(9-fluorenylmethyloxycarbonyl)-amino]-2-(trimethylsilyl)ethyl] phenoxy- acetic acid linkage agent for solid-phase synthesis of C-terminal peptide amides: improved yields of tryptophan-containing peptides. J Org Chem 58 : 2640 2646.
    • (1993) J Org Chem , vol.58 , pp. 2640-2646
    • Chao, H.-G.1    Bernatowich, M.S.2    Matsueda, G.R.3
  • 22
    • 0027420351 scopus 로고
    • Thymosin α1 down-regulates the growth of human non-small cell lung cancer cells in vitro and in vivo
    • Moody T.W., Fagarasan M., Zia F., Cesnjaj M., Goldstein A.L. (1993) Thymosin α1 down-regulates the growth of human non-small cell lung cancer cells in vitro and in vivo. Cancer Res 53 : 5214 5218.
    • (1993) Cancer Res , vol.53 , pp. 5214-5218
    • Moody, T.W.1    Fagarasan, M.2    Zia, F.3    Cesnjaj, M.4    Goldstein, A.L.5
  • 23
    • 0022504477 scopus 로고
    • Reconstitution of T cell function in aging mice by thymosin α1
    • Frasca D., Adorini L., Mancini C., Doria G. (1986) Reconstitution of T cell function in aging mice by thymosin α1. Immunopharmacology 11 : 155 163.
    • (1986) Immunopharmacology , vol.11 , pp. 155-163
    • Frasca, D.1    Adorini, L.2    Mancini, C.3    Doria, G.4
  • 24
    • 84985200995 scopus 로고
    • Eine neue Synthese von Thymosin α1
    • Echner H., Voelter W. (1988) Eine neue Synthese von Thymosin α1. Liebigs Ann Chem 1988, 11 : 1095 1097.
    • (1988) Liebigs Ann Chem , vol.1988 , Issue.11 , pp. 1095-1097
    • Echner, H.1    Voelter, W.2
  • 25
    • 3043007103 scopus 로고
    • Strategies for the total syntheses of thymosins
    • Voelter W., Kapurniotu A. (1991) Strategies for the total syntheses of thymosins. Stud Nat Prod Chem 8 : 433 461.
    • (1991) Stud Nat Prod Chem , vol.8 , pp. 433-461
    • Voelter, W.1    Kapurniotu, A.2
  • 26
    • 34447329784 scopus 로고    scopus 로고
    • Last Access: June 27, 2007. Available at:
    • Last Access: June 27, 2007. Available at: http://www.merckbiosciences.co. uk/SharedImages/novabiochem/01_06_innovM.pdf
  • 27
    • 12244301557 scopus 로고    scopus 로고
    • Radiochemical investigations of 99mTc-N3S-X-BBN(7-14)NH2: An in vitro/in vivo structure-activity relationship study where X = 0,3,5,8 and 11-carbon tethering moieties
    • Smith C.J., Gali H., Sieckman G.L., Higginbothman C., Volkert W.A., Hoffman T.J. (2003) Radiochemical investigations of 99mTc-N3S-X-BBN(7-14)NH2: an in vitro/in vivo structure-activity relationship study where X = 0,3,5,8 and 11-carbon tethering moieties. Bioconjug Chem 14 : 93 102.
    • (2003) Bioconjug Chem , vol.14 , pp. 93-102
    • Smith, C.J.1    Gali, H.2    Sieckman, G.L.3    Higginbothman, C.4    Volkert, W.A.5    Hoffman, T.J.6
  • 28
    • 0347991822 scopus 로고    scopus 로고
    • Gastrin releasing peptide (GRP) receptor targeted radiopharmaceuticals: A concise update
    • Smith C.J., Volkert W.A., Hoffman T.J. (2003) Gastrin releasing peptide (GRP) receptor targeted radiopharmaceuticals: a concise update. Nucl Med Biol 30 : 861 868.
    • (2003) Nucl Med Biol , vol.30 , pp. 861-868
    • Smith, C.J.1    Volkert, W.A.2    Hoffman, T.J.3
  • 29
    • 0022455250 scopus 로고
    • The chemistry of rhenium and technetium as related to the use of isotopes of these elements in therapeutic and diagnostic nuclear-medicine
    • Deutsch E., Lisbon K., Vanderheyden J.-L., Ketring A.R., Maxon H.R. (1986) The chemistry of rhenium and technetium as related to the use of isotopes of these elements in therapeutic and diagnostic nuclear-medicine. Nucl Med Biol 13 : 465 477.
    • (1986) Nucl Med Biol , vol.13 , pp. 465-477
    • Deutsch, E.1    Lisbon, K.2    Vanderheyden, J.-L.3    Ketring, A.R.4    Maxon, H.R.5
  • 30
    • 0032342440 scopus 로고    scopus 로고
    • The biomedical chemistry of technetium and rhenium
    • Dilworth J., Parrot S. (1998) The biomedical chemistry of technetium and rhenium. Chem Soc Rev 27 : 43 55.
    • (1998) Chem Soc Rev , vol.27 , pp. 43-55
    • Dilworth, J.1    Parrot, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.