Synthesis and biological evaluation of N-acetyl-β-aryl-1,2-didehydroethylamines as new HIV-1 RT inhibitors in vitro

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 16, 2007, Pages 4476-4480

  Cheng, Pi ^a,d   Jiang, Zhi Yong ^a,c   Wang, Rui Rui ^b   Zhang, Xue Mei ^a,c   Wang, Qian ^b   Zheng, Yong Tang ^b   Zhou, Jun ^a,c   Chen, Ji Jun ^a,c  

^a KUNMING INSTITUTE OF BOTANY   (China)

^b KUNMING INSTITUTE OF ZOOLOGY   (China)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^d UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Aryl nitroolefin; Anti HIV 1 RT activity; N Acetyl aryl 1,2 didehydroethylamine; NNRTIs

Indexed keywords

ALKENE DERIVATIVE; BETA ARYL NITROOLEFIN; ETHYLAMINE; N ACETYL BETA ARYL 1,2 DIDEHYDROETHYLAMINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

ETHYLAMINES; HIV REVERSE TRANSCRIPTASE; HIV-1; MOLECULAR STRUCTURE; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 34447311921     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.06.008     Document Type: Article

References (17)

1. Clercq E.D. Chem. Biodivers 1 (2004) 44
2. Burke Jr. T.R., Fesen M.R., Mzaumder A., Wang J., Carothers A.M., Grunberger D., Driscoll J., Kohn K., and Pommier Y. J. Med. Chem. 38 (1995) 4171
3. Kirkup M.P., and Moore R.E. Tetrahedron Lett. 24 (1983) 2087
4. Suksamrarn S., Suwannapoch N., Aunchai N., Kano M., Ratananukul P., Haritakun R., Jansakul C., and Ruchirawat S. Tetrahedron 61 (2005) 1175
5. Hassan W., Edrada R., Ebel R., Wray V., and Proksh P. Mar. Drugs 2 (2004) 88
6. Hallock Y.F., Manfredi K.P., Dai J.-R., Cardellina II J.H., Gulakowski R.J., McMahon J.B., Schaffer M., Stahl M., Gulden K.-P., Bringmann G., Francois G., and Boyd M.R. J. Nat. Prod. 60 (1997) 677
7. Wang Y., Chen J., Yang Y., Zheng Y., Tang S., and Luo S.H. Helv. Chim. Acta 85 (2002) 2342
8. Ishibashi H., Takamuro I., Okano M., Kenri T., and Ikeda M. Chem. Pharm. Bull. 37 (1989) 2214
9. Lohse C. Tetrahedron Lett. 54 (1968) 5625
10. Corbett R.E., and Davey C.L. J. Chem. Soc. (1955) 296
11. Laso N.M., Quiclet-Sire B., and Zard S.Z. Tetrahedron Lett. 37 (1996) 1605
12. + (35), 147 (49), 118 (100), 105 (85), 91 (77), 77 (47).
13. Wang Q., Ding Z.H., Liu J.K., and Zheng Y.T. Antiviral Res. 64 (2004) 189
14. Jiang T., Kuhen K.L., Wolff K., Yin H., Bieza K., Caldwell J., Bursulaya B., Wu T.Y., and He Y. Bioorg. Med. Chem. Lett. 16 (2006) 2105
15. Barreca M.L., Rao A., Laura D.L., Zappalà M., Monforte A., Maga G., Pannecouque C., Balzarini J., Clercq E.D., Chimirri A., and Monforte P. J. Med. Chem. 48 (2005) 3433
16. Zhang G.H., Wang Q., Chen J.J., Zhang X.M., Tam S.C., and Zheng Y.T. Biochem. Biophys. Res. Commun. 334 (2005) 812
17. Wang R.R., Gu Q., Yang L.M., Chen J.J., Li S.Y., and Zheng Y.T. J. Ethnopharmacol. 85 (2006) 283