Intrathecal viral replication and cerebral deficits in different stages of human immunodeficiency virus disease

Journal of NeuroVirology

Volumn 13, Issue 3, 2007, Pages 225-232

  Arendt, Gabriele ^a   Nolting, Thorsten ^a   Frisch, Christian ^a   Husstedt, Ingo Wilhelm ^a   Gregor, Nora ^a   Koutsilieri, Eleni ^b   Maschke, Mattias ^c   Angerer, Alexander ^c   Obermann, Mark ^c   Neuen Jacob, Eva ^d   Adams, Ortwin ^d   Loeffert, Sabine ^a   Riederer, Peter ^b   ter Meulen, Volker ^b   Sopper, Sieghart ^e  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY HOSPITAL ESSEN   (Germany)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e GERMAN PRIMATE CENTER   (Germany)

Author keywords

CSF; HIV; Neurology; Neuropsychological impairment

Indexed keywords

ANTIRETROVIRUS AGENT; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ADULT; ARTICLE; BISEXUALITY; BLOOD LEVEL; CD4 LYMPHOCYTE COUNT; CENTRAL NERVOUS SYSTEM INFECTION; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID CYTOLOGY; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DISEASE COURSE; EARLY INTERVENTION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HOMOSEXUALITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; LUMBAR PUNCTURE; MAJOR CLINICAL STUDY; NERVOUS SYSTEM INFLAMMATION; NEUROLOGIC DISEASE; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; STAGING; THERAPY DELAY; VEIN PUNCTURE; VIRUS LOAD; VIRUS REPLICATION;

ADULT; AIDS DEMENTIA COMPLEX; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CEREBROSPINAL FLUID; COGNITION DISORDERS; CROSS-SECTIONAL STUDIES; HIV-1; HUMANS; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; VIRAL LOAD; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 34447304630     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/13550280701315355     Document Type: Article

References (40)

1. Abdulle, S., Hagberg, L. and Gisslén, M. (2005) Effects of antiretroviral treatment on blood-brain barrier integrity and intrathecal immunoglobulin production in neuroasymptomatic HIV-1-infected patients. HIV Med, 6, pp. 164-169.
2. Arendt, G., Hefter, H., Elsing, C., Strohmeyer, G. and Freund, H. J. (1990) Motor dysfunction in HIV-infected patients without clinically detectable central-nervous deficit. J Neurol, 237, pp. 362-368.
3. Bestetti, A., Presi, S., Pienotti, C., Bossolasco, S., Sala, S., Racca, S., Carrera, P., Lazzarin, A. and Cinque, P. (2004) Long-term virological effect of highly active antiretroviral therapy on cerebrospinal fluid and relationship with genotypic resistance. J Neuro Virol, 10, pp. 52-57.
4. Brew, B., Pemberton, L., Cunningham, P. and Law, M. (1997) Levels of human immunodeficiency virus type 1 RNA in cerebrospinal fluid correlate with AIDS dementia stage. J Inf Dis, 175, pp. 963-966.
5. CDC (1993) Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. JAMA, 269:6, pp. 729-730.
6. Chiodi, F., Keys, B., Albert, J., Hagberg, L., Lundeberg, J., Uhlen, M., Fenyo, E. M. and Norkrans, G. (1992) Human immunodeficiency virus type I is present in the cerebrospinal fluid of a majority of infected individuals. J Clin Microbiol, 30, pp. 1768-1771.
7. Cinque, P., Sestetti, A., Morelli, P. and Presi, S. (2000) Molecular analysis of cerebrospinal fluid: Potential for the study of HIV-1 infection of the central nervous system. J NeuroVirol, 6, pp. 95-102.
8. De Luca, A., Ciancio, B. C., Larussa, D., Murri, R., Cingolati, A., Rizzo, M. G., Giancola, M. L., Ammassari, A. and Ortona, L. (2002) Correlates of independent HIV-1 replication in the CNS and of its control by antiretrovirals. Neurology, 59, pp. 342-347.
9. Ellis, R. J., Childers, M. E., Zimmerman, J. D., Frost, S. D., Deutsch, R. and McCutchan, J. A. (2003) Human immunodeficiency virus-l RNA levels in cerebrospinal fluid exhibit a set point in clinically stable patients not receiving antiretroviral therapy. J Infect Dis, 187, pp. 1818-1821.
10. Ellis, R., Gamst, A., Capparelli, E., Spector, S., Hisa, K., Wolfson, T., Abramson, I., Grant, I. and McCutchan, Hsic (2000) Cerebrospinal fluid HIV RNA originates from both local CNS and systemic sources. Neurology, 54, pp. 927-936.
11. Ellis, R. J., Hsia, K., Spector, S. A., Nelson, J. A., Heaton, R. K., Wallace, M. R., Abramson, I., Atkinson, J. H., Grant, I. and McCutchan, J. A. (1997) Cerebrospinal fluid human immunodeficiency virus type 1 RNA levels are elevated in neurocognitively impaired individuals with acquired immunodeficiency syndrome. HIV Neurobehavioral Research Center Group [see comments]. Ann Neurol, 42, pp. 679-688.
12. Garcia, F., Niebla, G., Romeu, J., Vidal, C., Plana, M., Ortega, M., Ruiz, L., Gallart, T., Clotet, B. and Miro, J. M. (1999) Cerebrospinal fluid HIV-l RNA levels in asymptomatic patients with early stage chronic HIV-l infection: Support for the hypothesis of local virus replication. AIDS, 13, pp. 1491-1496.
13. Gartner, S. (2000) HIV infection and dementia. Science, 287, pp. 602-604.
14. Giancola, M. L., Lorenzini, P., Balestra, P., Larussa, D., Baldini, F., Corpolongo, A., Narciso, P., Bellagamba, R., Tozzi, V. and Antinori, A. (2006) Neuroactive antiretroviral drugs do not influence neurocognitive performance in less advanced HIV-infected patients responding to highly active antiretroviral therapy. J Acquir Immune Defic Syndr, 41, pp. 332-337.
15. von Giesen, H. J., Adams, O., Koller, H. and Arendt, G. (2005) Cerebrospinal fluid HIV viral load in different phases of HIV-associated brain disease. J Neurol, 252, pp. 801-807.
16. von Giesen, H. J., Hefter, H., Roick, H., Mauss, S. and Arendt, G. (1994) HIV-specific changes in the motor performance of HIV-positive intravenous drug abusers. J Neurol, 242, pp. 20-25.
17. Gisslén, M., Fuchs, D., Svennerholm, B. and Hagberg, L. (1999) Cerebrospinal fluid viral load, intrathecal immunoactivation, and cerebrospinal fluid monocytic cell count in HIV-l infection. J Acquir Immune Defic Syndr, 21, pp. 271-276.
18. Gisslén, M., Hagberg, L., Fuchs, D., Norkrans, G. and Svennerholm, B. (1998) Cerebrospinal fluid viral load in HIV-1-infected patients without antiretroviral treatment: A longitudinal study. J Acquir Immune Defic Syndr Hum Retrovirol, 17, pp. 291-295.
19. Harrington, P. R., Haas, D. W., Ritola, K. and Swanstrom, R. (2005) Compartmentalized human immunodeficiency virus type 1 present in cerebrospinal fluid is produced by short-lived cells. J Virol, 79, pp. 7959-7966.
20. Klove, H. (1963) Clinical neuropsychology, Saunders, New York
21. Korber, B. T., Kunstmann, K. J., Patterson, B. K., Furtado, M., McEvilly, M. M., Levy, R. and Wolinsky, S. M. (1994) Genetic differences between blood- and brain-derived viral sequences from human immunodeficiency virus type 1-infected patients: Evidence of conserved elements in the V3 region of the envelope protein brain-derived sequences. J Virol, 68, pp. 7467-7481.
22. Lambotte, O., Deiva, K. and Tardieu, M. (2003) HIV-l persistence, viral reservoir, and the central nervous system in the HAART era. Brain Pathol, 13, pp. 95-103.
23. Marshall, D., Brey, R., Cahill, W., Houk, R., Zajac, R. and Boswell, R. (1988) Spectrum of cerebrospinal fluid findings in various stages of human immunodeficiency virus infection. Arch Neurol, 45, pp. 954-958.
24. Martin, C., Albert, J., Hansson, P., Pehrsson, P., Link, H. and Sonnerborg, A. (1998) Cerebrospinal fluid mononuclear cell counts influence CSF HIV-l RNA levels. J Acquir Immun Def Syndr Human Retrovirol, 17, pp. 214-219.
25. McArthur, J. C., McClemon, D. R., Cronin, M. F., Nance-Sproson, T. E., Saah, A. J., Clair, M St and Lanier, E. R. (1997) Relationship between human immunodeficiency virus-associated dementia and viral load in cerebrospinal fluid and brain [see comments]. Ann Neurol, 42, pp. 689-698.
26. Monteiro, de, Almeida, S., Letendre, S., Zimmerman, J., Lazzaretto, D., McCutchan, A. and Ellis, R. (2005) Dynamics of monocyte chemoattractant protein type one (MCP-1) and HIV viral load in human cerebrospinal fluid and plasma. J Neuroimmunol, 169, pp. 144-152.
27. Peeters, M. F., Colebunders, R. L., Abbeele, K Van den, Nys, P. C., Goeman, J., Colans, P., Geerts, Y. and Groen, G Van den (1995) Comparison of human immunodeficiency virus biological phenotypes isolated from cerebrospinal fluid and peripheral blood. J Med Virol, 47, pp. 92-96.
28. Price, R. W. (2000) The two faces of HIV infection of cerebrospinal fluid. Trends Microbiol, 8, pp. 387-391.
29. Price, R. W. and Staprans, S. Measuring the "viral load" in cerebrospinal fluid in human immunodeficiency virus infection: Window into brain infection?. Ann Neurol, 42, pp. 675-678.
30. Price, R. W., Yiannoutsos, C. T., Clifford, D. B., Zaborski, L., Tselis, A., Sidtis, J. J., Cohen, B., Hall, C. D., Erice, A. and Henry, K. (1999) Neurological outcomes in late HIV infection: Adverse impact of neurological impairment on survival and protective effect of antiviral therapy. AIDS Clinical Trial Group and Neurological AIDS Research Consortium study team. AIDS, 13, pp. 1677-1685.
31. Reitan, R. M. and Wolfson, D. (1985)
32. Sacktor, N. C., Lyles, R. H., Skolasky, R. L., Anderson, D. E., McArthur, J. C., McFarlane, G., Selnes, O. A., Becker, J. T., Cohen, B., Wesch, J. and Miller, E. N. (1999) Combination antiretroviral therapy improves psychomotor speed performance in HIV-seropositive homosexual men. Multicenter AIDS Cohort Study (MACS). Neurology, 52, pp. 1640-1647.
33. Scheller, C., Sopper, S., Jenuwein, M., Neuen-Jacob, E., Tatschner, T., Grunblatt, E., Meulen, V ter, Riederer, P. and Koutsilieri, E. (2005) Early impairment in dopaminergic neurotransmission in brains of SIV-infected rhesus monkeys due to microglia activation. J Neurochem, 95, pp. 377-387.
34. Siliciano, J. D. and Siliciano, R. F. (2004) A long-term latent reservoir for HIV-l: Discovery and clinical implications. J Antimicrob Chemother, 54, pp. 6-9.
35. Spector, S. A., Hsia, K., Pratt, D., Lathey, J., McCutchan, J. A., Alcaraz, J. E., Atkinson, J. H., Gulevich, S., Wallace, M. and Grant, I. (1993) Virological markers of human immunodeficiency virus type I in cerebrospinal fluid. The HIV Neurobehavioral Research Center Group. J Infect Dis, 168, pp. 68-74.
36. Spreen, O. and Strauss, E. (1998) A compendium of neuropsychological tests, Oxford University Press, New York
37. Spudich, S. S., Lollo, N. D., Liegler, T., Deeks, S TG and Price, R. W. (2006) Treatment benefit on cerebrospinal fluid HIV-1 levels in the setting of systemic virological suppression and failure. JID, 194, pp. 1686-1696.
38. Spudich, S. S., Nilsson, A. C., Lollo, N. D., Liegler, T. J., Petropoulos, C. J., Deeks, S. G., Paxinos, E. E. and Price, R. W. (2005) Cerebrospinal fluid HIV infection and pleocytosis: Relation to systemic infection and antiretroviral treatment. BMC Infect Dis, 5, p. 98.
39. Staprans, S., Marlowe, N., Glidden, D., Novakovic-Agopian, T., Grant, R. M., Heyes, M., Aweeka, F., Deeks, S. and Price, R. W. (1999) Time course of cerebrospinal fluid responses to antiretroviral therapy: Evidence for variable compartmentalization of infection. AIDS, 13, pp. 1051-1061.
40. Stingele, K., Haas, J., Zimmermann, T., Stingele, R., Hubsch-Muller, C., Freitag, M., Storch-Hagenlocher, B., Hartmann, M. and Wildemann, B. (2001) Independent HIV replication in paired CSF and blood viral isolates during antiretroviral therapy. Neurology, 56, pp. 355-361.