Disposition and metabolic fate of prasugrel in mice, rats, and dogs

Xenobiotica

Volumn 37, Issue 8, 2007, Pages 884-901

  Smith, R L ^a   Gillespie, T A ^a   Rash, T J ^a   Kurihara, A ^b   Farid, N A ^a  

^a ELI LILLY AND COMPANY   (United States)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

Cysteine conjugation; Ester hydrolysis; Prasugrel metabolism and disposition; S methylation; Species comparison; Thienopyridine; Thiol metabolites

Indexed keywords

CARBON 14; DRUG METABOLITE; ESTERASE; PRASUGREL; THIOL DERIVATIVE; THIOLACTONE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG METABOLISM; FECES ANALYSIS; HYDROLYSIS; MALE; METHYLATION; MOUSE; NONHUMAN; RADIOACTIVITY; RAT; URINALYSIS;

ADMINISTRATION, ORAL; ANIMALS; CARBON RADIOISOTOPES; DOGS; FECES; MALE; MASS SPECTROMETRY; MICE; PIPERAZINES; PRODRUGS; RATS; SULFHYDRYL COMPOUNDS; THIOPHENES;

ANIMALIA; CANIS FAMILIARIS; MUS; RATTUS;

EID: 34447300725     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250701485542     Document Type: Article

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