Pioglitazone as a therapeutic agent in autistic spectrum disorder

Medical Hypotheses

Volumn 69, Issue 3, 2007, Pages 699-

  Emanuele, Enzo ^a   Lossano, Cecilia ^a   Politi, Pierluigi ^a   Barale, Francesco ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; PROTEIN TYROSINE KINASE; SCATTER FACTOR RECEPTOR;

AUTISM; DRUG MECHANISM; HUMAN; HYPOTHESIS; LETTER; NEUROBIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SEIZURE SUSCEPTIBILITY;

CLINICAL TRIALS; HUMANS; HYPOGLYCEMIC AGENTS; INFLAMMATION; MODELS, BIOLOGICAL; MODELS, THEORETICAL; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MET; SIGNAL TRANSDUCTION; THIAZOLIDINEDIONES; TREATMENT OUTCOME;

EID: 34447277676     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2007.01.018     Document Type: Letter

References (7)

1. Francis K. Autism interventions: a critical update. Dev Med Child Neurol 47 (2005) 493-499
2. Tuchman R., and Rapin I. Epilepsy in autism. Lancet Neurol 1 (2002) 352-358
3. Campbell D.B., Sutcliffe J.S., Ebert P.J., Militerni R., Bravaccio C., Trillo S., et al. A genetic variant that disrupts MET transcription is associated with autism. Proc Natl Acad Sci USA 103 (2006) 16834-16839
4. Tomita K., Azuma T., Kitamura N., Nishida J., Tamiya G., Oka A., et al. Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met. Gastroenterology 126 (2004) 873-885
5. Heneka M.T., Sastre M., Dumitrescu-Ozimek L., Hanke A., Dewachter I., Kuiperi C., et al. Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain 128 (2005) 1442-1453
6. Vargas D.L., Nascimbene C., Krishnan C., Zimmerman A.W., and Pardo C.A. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol 57 (2005) 67-81
7. Okada K., Yamashita U., and Tsuji S. Ameliorative effect of pioglitazone on seizure responses in genetically epilepsy-susceptible EL mice. Brain Res 1102 (2006) 175-178