Synthesis and pharmacochemical evaluation of novel aryl-acetic acid inhibitors of lipoxygenase, antioxidants, and anti-inflammatory agents

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 17, 2007, Pages 5819-5827

  Pontiki, E ^a   Hadjipavlou Litina, D ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Anti inflammatory agents; Antioxidant agents; Aryl acetic acids; Lipoxygenase inhibitors

Indexed keywords

3 (3,5 DI TERT BUTYL 2 HYDROXYPHENYL) 2 PHENYLACRYLIC ACID; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ARACHIDONIC ACID; ARYLACETIC ACID DERIVATIVE; GLUTATHIONE; LEUKOTRIENE; LIPOXYGENASE; LIPOXYGENASE INHIBITOR; NAPHTHALENE; PHENOL DERIVATIVE; PYRROLE DERIVATIVE; REACTIVE OXYGEN METABOLITE; SCAVENGER; THIEPIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARACHIDONIC ACID METABOLISM; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; HOST RESISTANCE; LIPOPHILICITY; MALE; NONHUMAN; PAW EDEMA; RAT;

ACETIC ACID; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; CARRAGEENAN; EDEMA; FREE RADICALS; HINDLIMB; LIPOXYGENASE INHIBITORS; MOLECULAR STRUCTURE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

GLYCINE MAX;

EID: 34447268471     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.06.001     Document Type: Article

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