Strong and selective inhibitors of hepatitis B virus replication among novel N4-hydroxy- and 5-methyl-β-L-deoxycytidine analogues

Antimicrobial Agents and Chemotherapy

Volumn 51, Issue 7, 2007, Pages 2523-2530

  Matthes, E ^a   Funk, A ^b   Krahn, I ^a   Gaertner, K ^a   Von Janta Lipinski, M ^a   Lin, L ^b,c   Will, H ^b   Sirma, H ^b  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYL BETA LEVO DEOXYCYTIDINE DERIVATIVE; BETA LEVO 2',3' DIDEHYDRO 2',3' DIDEOXY N4 HYDROXYCYTIDINE; BETA LEVO 2',3' DIDEOXY 3' THIA N4 HYDROXYCYTIDINE; BETA LEVO 2',3' DIDEOXY N4 HYDROXYCYTIDINE; BETA LEVO 5 METHYL 2' DEOXYCYTIDINE; DEOXYCYTIDINE; DNA POLYMERASE; LAMIVUDINE; UNCLASSIFIED DRUG; VIRUS DNA;

ANTIVIRAL ACTIVITY; ARTICLE; CELL STRAIN HEPG2; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; VIRUS INHIBITION; VIRUS REPLICATION;

ANTIVIRAL AGENTS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DEOXYCYTIDINE; DNA-DIRECTED DNA POLYMERASE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATITIS B VIRUS; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LIVER NEOPLASMS; MOLECULAR STRUCTURE; TIME FACTORS; TRANSFECTION; VIRUS REPLICATION;

EID: 34447264981     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00001-07     Document Type: Article

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