A fatality due to alprazolam intoxication

Journal of Analytical Toxicology

Volumn 21, Issue 3, 1997, Pages 218-220

  Jenkins, Amanda J ^a   Levine, Barry ^a   Locke, J Laron ^a   Smialek, John E ^a  

^a OFFICE OF THE CHIEF MEDICAL EXAMINER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPRAZOLAM; BORATE SODIUM; CHLORDIAZEPOXIDE; DICHLOROMETHANE; DIETHYLAMINE; FLUOXETINE; LORAZEPAM; METHANOL; PHENYTOIN; VENLAFAXINE;

ADULT; ARTICLE; AUTOPSY; CASE REPORT; CONTROLLED STUDY; DRUG BILE LEVEL; DRUG INTOXICATION; DRUG LIVER LEVEL; DRUG OVERDOSE; DRUG TISSUE LEVEL; DRUG URINE LEVEL; FATALITY; FEMALE; GAS CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MASS SPECTROMETRY; ORAL DRUG ADMINISTRATION; TISSUE HOMOGENATE;

EID: 0031020998     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/21.3.218     Document Type: Article

References (11)

1. R.C. Baselt and R.H. Cravey. Disposition of Toxic Drugs and Chemicals in Man. 4th ed. Chemical Toxicology Institute, Foster City, CA, 1995.
2. Physicians' Desk Reference. 48th ed. Medical Economics Data Production, Montvale, NJ, 1994.
3. S.R. McCormick, J. Nielsen, and P. Jatlow. Quantification of alprazolam in serum or plasma by liquid chromatography. Clin. Chem. 30: 1652-55 (1984).
4. D.A. Ciraulo, J.G. Barnhill, H.G. Boxenbaum, D.J. Greenblatt, and R.B. Smith. Pharmacokinetics and clinical effects of alprazolam following single and multiple oral doses in patients with panic disorder. J. Clin. Pharmacol. 26: 292-98 (1986).
5. G.W. Dawson, S.G. Jue, and R.N. Brogden. Alprazolam. A review of its pharmacodynamic properties and efficacy in the treatment of anxiety and depression. Drugs 27: 132-47 (1984).
6. R.B. Smith and P.D. Kroboth. Influence of dosing regimen on alprazolam and metabolite serum concentrations and tolerance to sedative and psychomotor effects. Psychopharmacology 93: 105-12 (1987).
7. L.E. Edinboro and R.C. Backer. Preliminary report on the application of a high performance liquid chromatographic method for alprazolam in postmortem blood specimens. J. Anal. Toxicol. 9: 207-208 (1985).
8. R.L. Miller, and C.L. DeVane. Alprazolam, α-hydroxy-and 4-hydroxyalprazolam analysis in plasma by high performance liquid chromatography. J. Chromatogr. 430: 180-86 (1988).
9. V.D. Schmith, S.R. Cox, M.A. Zemaitis, and P.D. Kroboth. New high-performance liquid chromatographic method for the determination of alprazolam and its metabolites in serum: Instability of 4-hydroxyalprazolam. J. Chromatogr. 568: 253-60 (1991).
10. H. Cardauns and R. Iffland. Ueber eine toedliche Diazepam (Valium) Vergiftung bei einem drogenabhaengigen Jugendlichen. Arch. Toxicol. 31: 147-51 (1973).
11. D.T. Stafford, A.M. Phillips, G.S. Fernandez, and H.S. Nichols. Xanax (alprazolam) - An overdose death. Abstract. American Academy of Forensic Sciences Annual Meeting, Anaheim, CA, February 23, 1984.