Conformationally locked thiosugars as potent α-mannosidase inhibitors: Synthesis, biochemical and docking studies

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 17, 2007, Pages 5659-5665

  Sivapriya, K ^a   Hariharaputran, S ^a   Suhas, V L ^a   Chandra, N ^a   Chandrasekaran, S ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

Mannosidase; Docking studies; Inhibition; Thiosugars

Indexed keywords

1 DEOXYMANNONOJIRIMYCIN; 1,6 DIDEOXY 1,6 EPISULFONYL BETA DEXTRO MANNOSE; ALPHA MANNOSIDASE INHIBITOR; CARBOHYDRATE DERIVATIVE; KIFUNENSINE; MANNOSIDASE INHIBITOR; SULFONE DERIVATIVE; THIOLEVOMANNOSAN DERIVATIVE; THIOSUGAR DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; DRUG ACTIVITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; HYDROGEN BOND; MICHAELIS CONSTANT;

ALPHA-MANNOSIDASE; CARBOHYDRATES; ENZYME INHIBITORS; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; SAFROLE; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; SULFONES;

CANAVALIA ENSIFORMIS;

EID: 34447254040     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.06.011     Document Type: Article

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