Effect of oral insulin on insulin autoantibody levels in the Diabetes Prevention Trial Type 1 oral insulin study

Diabetologia

Volumn 50, Issue 8, 2007, Pages 1603-1606

  Barker, J M ^a   McFann, K K ^a   Orban, T ^b  

^a UNIVERSITY OF COLORADO DENVER   (United States)

^b JOSLIN DIABETES CENTER   (United States)

Author keywords

Insulin autoantibodies; Oral insulin; Prevention; Type 1 diabetes

Indexed keywords

AUTOANTIBODY; INSULIN ANTIBODY; PLACEBO; RECOMBINANT HUMAN INSULIN;

ANTIBODY BLOOD LEVEL; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; HUMAN; INTRAVENOUS GLUCOSE TOLERANCE TEST; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; DIABETES MELLITUS, TYPE 1; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN ANTIBODIES; MALE; TIME FACTORS;

EID: 34447132472     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0694-0     Document Type: Article

References (10)

1. Diabetes Prevention Trial Type 1 Study Group (2005) Effects of oral insulin in relatives of patients with type 1 diabetes: the Diabetes Prevention Trial-Type 1. Diabetes Care 28:1068-1076
2. Lauritano AA, Clements RS Jr, Bell D (1989) Insulin antibodies in non-insulin-dependent diabetes mellitus: effect of treatment with semisynthetic human insulin. Clin Ther 11:268-277
3. Diabetes Prevention Trial Type 1 Study Group (2002) Effects of insulin in relatives of patients with type 1 diabetes mellitus. N Engl J Med 346:1685-1691
4. Vardi P, Dib SA, Tuttleman M et al (1987) Competitive insulin autoantibody assay. Prospective evaluation of subjects at high risk for development of type 1 diabetes mellitus. Diabetes 36:1286-1291
5. Jones RH (1993) Longitudinal data with serial correlation: a state-space approach. Monogr Stat Appl Probab 47:25-76
6. Achenbach P, Warncke K, Reiter J et al (2004) Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics. Diabetes 53:384-392
7. Hoppu S, Ronkainen MS, Kimpimaki T et al (2004) Insulin autoantibody isotypes during the prediabetic process in young children with increased genetic risk of type 1 diabetes. Pediatr Res 55:236-242
8. Achenbach P, Koczwara K, Knopff A, Naserke H, Ziegler AG, Bonifacio E (2004) Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes. J Clin Invest 114:589-597
9. Achenbach P, Warncke K, Reiter J et al (2006) Type 1 diabetes risk assessment: improvement by follow-up measurements in young islet autoantibody-positive relatives. Diabetologia 49:2969-2976
10. van de Linde P, Roep BO (2005) T-cell assays to determine disease activity and clinical efficacy of immune therapy in type 1 diabetes. Am J Ther 12:573-579