-
1
-
-
1542316127
-
Mechanisms of disease: Hepatitis B virus infection - natural history and clinical consequences
-
Ganem, D., Prince, A.M. Mechanisms of disease: Hepatitis B virus infection - natural history and clinical consequences. N Engl J Med 2004, 350: 1118-29.
-
(2004)
N Engl J Med
, vol.350
, pp. 1118-1129
-
-
Ganem, D.1
Prince, A.M.2
-
2
-
-
0025245580
-
Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection
-
Ferrari, C., Penna, A., Bertoletti, A. et al. Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection. J Immunol 1990, 145: 3442-9.
-
(1990)
J Immunol
, vol.145
, pp. 3442-3449
-
-
Ferrari, C.1
Penna, A.2
Bertoletti, A.3
-
3
-
-
0027023065
-
Immune pathogenesis of hepatitis B
-
Ferrari, C., Penna, A., Bertoletti, A. et al. Immune pathogenesis of hepatitis B. Arch Virol Suppl 1992, 4: 11-8.
-
(1992)
Arch Virol Suppl
, vol.4
, pp. 11-18
-
-
Ferrari, C.1
Penna, A.2
Bertoletti, A.3
-
4
-
-
2442682870
-
Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: Implications for immunotherapy
-
Webster, G.J., Reignat, S., Brown, D. et al. Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: Implications for immunotherapy. J Virol 2004, 78: 5707-19.
-
(2004)
J Virol
, vol.78
, pp. 5707-5719
-
-
Webster, G.J.1
Reignat, S.2
Brown, D.3
-
5
-
-
0030696048
-
Long-term outcome of hepatitis B e antigen-positive patients with compensated cirrhosis treated with interferon alfa
-
Fattovich, G., Giustina, G., Realdi, G. et al. Long-term outcome of hepatitis B e antigen-positive patients with compensated cirrhosis treated with interferon alfa. Hepatology 1997, 26: 1338-42.
-
(1997)
Hepatology
, vol.26
, pp. 1338-1342
-
-
Fattovich, G.1
Giustina, G.2
Realdi, G.3
-
6
-
-
0027243462
-
Risk factors for hepatocellular carcinoma among patients with chronic liver disease
-
Tsukuma, H., Hiyama, T., Tanaka, S. et al. Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med 1993, 328: 1797-801.
-
(1993)
N Engl J Med
, vol.328
, pp. 1797-1801
-
-
Tsukuma, H.1
Hiyama, T.2
Tanaka, S.3
-
7
-
-
84984555343
-
Hepatitis B e antigen and the risk of hepatocellular carcinoma
-
Yang, H.I., Lu, S.N., Liaw, Y.F. et al. Hepatitis B e antigen and the risk of hepatocellular carcinoma. N Engl J Med 2002, 347: 168-74.
-
(2002)
N Engl J Med
, vol.347
, pp. 168-174
-
-
Yang, H.I.1
Lu, S.N.2
Liaw, Y.F.3
-
8
-
-
33644858331
-
Predicting cirrhosis risk based on the level of circulating hepatitis B viral load
-
Iloeje, U.H., Yang, H.I., Su, J. et al. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterol 2006, 130: 678-86.
-
(2006)
Gastroenterol
, vol.130
, pp. 678-686
-
-
Iloeje, U.H.1
Yang, H.I.2
Su, J.3
-
9
-
-
0029893146
-
Long-term follow-up of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B
-
Niederau, C., Heintges, T., Lange, S. et al. Long-term follow-up of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B. N Engl J Med 1996, 334: 1422-7.
-
(1996)
N Engl J Med
, vol.334
, pp. 1422-1427
-
-
Niederau, C.1
Heintges, T.2
Lange, S.3
-
10
-
-
33644858331
-
Predicting cirrhosis risk based on the level of circulating hepatitis B viral load
-
Iloeje, U.H., Yang, H.I., Su, J. et al. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterol 2006, 130: 678-86.
-
(2006)
Gastroenterol
, vol.130
, pp. 678-686
-
-
Iloeje, U.H.1
Yang, H.I.2
Su, J.3
-
11
-
-
0022263140
-
Clinical and serological events accompanying changes in hepatitis B viral replication: Case reports
-
Dusheiko, G.M., Bowyer, S.M., Paterson, A. et al. Clinical and serological events accompanying changes in hepatitis B viral replication: Case reports. Liver 1985, 5: 77-83.
-
(1985)
Liver
, vol.5
, pp. 77-83
-
-
Dusheiko, G.M.1
Bowyer, S.M.2
Paterson, A.3
-
12
-
-
0019522817
-
Seroconversion from hepatitis B e antigen to antibody in chronic type B hepatitis
-
Hoofnagle, J.H., Dusheiko, G.M., Seeff, L.B. et al. Seroconversion from hepatitis B e antigen to antibody in chronic type B hepatitis. Ann Intern Med 1981, 94: 744-8.
-
(1981)
Ann Intern Med
, vol.94
, pp. 744-748
-
-
Hoofnagle, J.H.1
Dusheiko, G.M.2
Seeff, L.B.3
-
13
-
-
32044452719
-
Chronic hepatitis B: A critical appraisal of cur rent approaches to therapy
-
Perrillo, R.P., Gish, R.G., Peters, M. et al. Chronic hepatitis B: A critical appraisal of cur rent approaches to therapy. Clin Gastroenterol Hepatol 2006, 4: 233-48.
-
(2006)
Clin Gastroenterol Hepatol
, vol.4
, pp. 233-248
-
-
Perrillo, R.P.1
Gish, R.G.2
Peters, M.3
-
14
-
-
0035172399
-
Antiviral L-nucleosides specific for hepatitis B virus infection
-
Bryant, M.L., Bridges, E.G., Placidi, L. et al. Antiviral L-nucleosides specific for hepatitis B virus infection. Antimicrob Agents Chemother 1901, 45: 229-35.
-
(1901)
Antimicrob Agents Chemother
, vol.45
, pp. 229-235
-
-
Bryant, M.L.1
Bridges, E.G.2
Placidi, L.3
-
15
-
-
0034846501
-
Anti-HBV specific beta-L-2′-deoxynucleosides
-
Bryant, M.L., Bridges, E.G., Placidi, L. et al. Anti-HBV specific beta-L-2′-deoxynucleosides. Nucleosides Nucleotides Nucleic Acids 2001, 20: 597-607.
-
(2001)
Nucleosides Nucleotides Nucleic Acids
, vol.20
, pp. 597-607
-
-
Bryant, M.L.1
Bridges, E.G.2
Placidi, L.3
-
16
-
-
0034808628
-
Antiviral beta-L-nucleosides specific for hepatitis B virus infection
-
Standring, D.N., Bridges, E.G., Placidi, L. et al. Antiviral beta-L-nucleosides specific for hepatitis B virus infection. Antivir Chem Chemother 2001, 12(Suppl. 1): 119-29.
-
(2001)
Antivir Chem Chemother
, vol.12
, Issue.SUPPL. 1
, pp. 119-129
-
-
Standring, D.N.1
Bridges, E.G.2
Placidi, L.3
-
17
-
-
34247325630
-
Telbivudine preclinical safety studies suggest minimal risk of chronic toxicity, reproductive toxicity or carcinogenicity
-
Bridges, E. Telbivudine preclinical safety studies suggest minimal risk of chronic toxicity, reproductive toxicity or carcinogenicity. Gastroenterol 2006, 130: A847.
-
(2006)
Gastroenterol
, vol.130
-
-
Bridges, E.1
-
18
-
-
33644923505
-
Looking to the future: New agents for chronic hepatitis B
-
Dienstag, J.L. Looking to the future: New agents for chronic hepatitis B. Amer J Gastroenterol 2006, 101: S19-25.
-
(2006)
Amer J Gastroenterol
, vol.101
-
-
Dienstag, J.L.1
-
19
-
-
34447122170
-
Telbivudine phosphorylation by three enzymes: Implications for anti-hepatitis B virus activity in vitro and in the clinic
-
Golitsina, N., Danehy, F., Fellows, R. et al. Telbivudine phosphorylation by three enzymes: Implications for anti-hepatitis B virus activity in vitro and in the clinic. Hepatology 2006, 44: 561A.
-
(2006)
Hepatology
, vol.44
-
-
Golitsina, N.1
Danehy, F.2
Fellows, R.3
-
20
-
-
33747052308
-
Single-dose and multiple-dose pharmacokinetics and safety of telbivudine after oral administration in healthy Chinese subjects
-
Hu, P., Jiang, J., Wang, H.Y. et al. Single-dose and multiple-dose pharmacokinetics and safety of telbivudine after oral administration in healthy Chinese subjects. J Clin Pharmacol 2006, 46: 999-1007.
-
(2006)
J Clin Pharmacol
, vol.46
, pp. 999-1007
-
-
Hu, P.1
Jiang, J.2
Wang, H.Y.3
-
21
-
-
4544271613
-
A dose-finding study of once-daily oral telbivudine in HBeAg-positive patients with chronic hepatitis B virus infection
-
Lai, C.L., Lim, S.G., Brown, N.A. et al. A dose-finding study of once-daily oral telbivudine in HBeAg-positive patients with chronic hepatitis B virus infection. Hepatol 2004, 40: 719-26.
-
(2004)
Hepatol
, vol.40
, pp. 719-726
-
-
Lai, C.L.1
Lim, S.G.2
Brown, N.A.3
-
22
-
-
32944455131
-
Absence of food effect on the pharmacokinetics of telbivudine following oral administration in healthy subjects
-
Zhou, X.J., Lloyd, D.M., Chao, G.C. et al. Absence of food effect on the pharmacokinetics of telbivudine following oral administration in healthy subjects. J Clin Pharmacol 2006, 46: 275-81.
-
(2006)
J Clin Pharmacol
, vol.46
, pp. 275-281
-
-
Zhou, X.J.1
Lloyd, D.M.2
Chao, G.C.3
-
23
-
-
33644481515
-
Absence of pharmacokinetic drug-drug interaction between telbivudine and lamivudine or adefovir in healthy subjects
-
Zhou, X.J., Lloyd, D.M., Fielman, B.A. et al. Absence of pharmacokinetic drug-drug interaction between telbivudine and lamivudine or adefovir in healthy subjects. J Hepatol 2005, 42: 197-8.
-
(2005)
J Hepatol
, vol.42
, pp. 197-198
-
-
Zhou, X.J.1
Lloyd, D.M.2
Fielman, B.A.3
-
24
-
-
19044397678
-
Clinical pharmacokinetics of telbivudine, a potent antiviral for hepatitis B, in subjects with impaired hepatic or renal function
-
Zhou, X.J., Myers, M., Chao, G. et al. Clinical pharmacokinetics of telbivudine, a potent antiviral for hepatitis B, in subjects with impaired hepatic or renal function. J Hepatol 2004, 40: 134.
-
(2004)
J Hepatol
, vol.40
, pp. 134
-
-
Zhou, X.J.1
Myers, M.2
Chao, G.3
-
25
-
-
33646445007
-
Pharmacokinetics of telbivudine in subjects with various degrees of hepatic impairment
-
Zhou, X.J., Marbury, T.C., Alcorn, H.W. et al. Pharmacokinetics of telbivudine in subjects with various degrees of hepatic impairment. Antimicrob Agents Chemother 2006, 50: 1721-6.
-
(2006)
Antimicrob Agents Chemother
, vol.50
, pp. 1721-1726
-
-
Zhou, X.J.1
Marbury, T.C.2
Alcorn, H.W.3
-
26
-
-
33644662858
-
Pharmacokinetics of telbivudine following oral administration of escalating single and multiple doses in patients with chronic hepatitis B virus infection: Pharmacodynamic implications
-
Zhou, X.J., Lim, S.G., Lloyd, D.M. et al. Pharmacokinetics of telbivudine following oral administration of escalating single and multiple doses in patients with chronic hepatitis B virus infection: Pharmacodynamic implications. Antimicrob Agents Chemother 2006, 50: 874-9.
-
(2006)
Antimicrob Agents Chemother
, vol.50
, pp. 874-879
-
-
Zhou, X.J.1
Lim, S.G.2
Lloyd, D.M.3
-
27
-
-
33745584135
-
Pharmacokinetics of telbivudine in healthy subjects and absence of drug interaction with lamivudine or adefovir dipivoxil
-
Zhou, X.J., Fielman, B.A., Lloyd, D.M. et al. Pharmacokinetics of telbivudine in healthy subjects and absence of drug interaction with lamivudine or adefovir dipivoxil. Antimicrob Agents Chemother 2006, 50: 2309-15.
-
(2006)
Antimicrob Agents Chemother
, vol.50
, pp. 2309-2315
-
-
Zhou, X.J.1
Fielman, B.A.2
Lloyd, D.M.3
-
28
-
-
34447125265
-
Two-year results of a phase III comparative trial of telbivudine vs. lamivudine in Chinese patients
-
Jia, J.-D., Hou, J.-L., Xu, D.-Z. et al. Two-year results of a phase III comparative trial of telbivudine vs. lamivudine in Chinese patients. J Hepatol 2007, 46 (Suppl. 1): S189.
-
(2007)
J Hepatol
, vol.46
, Issue.SUPPL. 1
-
-
Jia, J.-D.1
Hou, J.-L.2
Xu, D.-Z.3
-
29
-
-
36348947122
-
76-week follow up of HBeAg-positive chronic hepatitis B patients treated with telbuvidine adefovir or switched from adefovir to telbivudine
-
Marcellin, P., Chan, H.L.Y., Lai, C.-L. et al. 76-week follow up of HBeAg-positive chronic hepatitis B patients treated with telbuvidine adefovir or switched from adefovir to telbivudine. J Hepatol 2007, 46 (Suppl. 1): S55.
-
(2007)
J Hepatol
, vol.46
, Issue.SUPPL. 1
-
-
Marcellin, P.1
Chan, H.L.Y.2
Lai, C.-L.3
-
30
-
-
23244453590
-
A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen- positive chronic hepatitis B
-
Lai, C.L., Leung, N., Teo, E.K. et al. A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen- positive chronic hepatitis B. Gastroenterol 2005, 129: 528-36.
-
(2005)
Gastroenterol
, vol.129
, pp. 528-536
-
-
Lai, C.L.1
Leung, N.2
Teo, E.K.3
-
31
-
-
33645083291
-
Telbivudine (LdT) vs. lamivudine for chronic hepatitis B: First-year results from the international phase III GLOBE trial
-
Lai, C.L., Gane, E., Liaw, Y.F. et al. Telbivudine (LdT) vs. lamivudine for chronic hepatitis B: First-year results from the international phase III GLOBE trial. Hepatol 2005, 42: 748A.
-
(2005)
Hepatol
, vol.42
-
-
Lai, C.L.1
Gane, E.2
Liaw, Y.F.3
-
32
-
-
33846067615
-
Two-year results from the GLOBE trial in patients with hepatitis B: Greater clinical and antiviral efficacy for telbivudine (LdT) vs. lamivudine
-
Lai, C.L., Gane, E., Hsu, C.W. et al. Two-year results from the GLOBE trial in patients with hepatitis B: Greater clinical and antiviral efficacy for telbivudine (LdT) vs. lamivudine. Hepatol 2006, 44: 222A.
-
(2006)
Hepatol
, vol.44
-
-
Lai, C.L.1
Gane, E.2
Hsu, C.W.3
-
33
-
-
33847667158
-
Telbivudine GLOBE trial: Maximal early HBV suppression is predictive of optimal two-year efficacy in nucleoside-treated hepatitis B patients
-
Dibisceglie, A., Lai, C.L., Gane, E. et al. Telbivudine GLOBE trial: Maximal early HBV suppression is predictive of optimal two-year efficacy in nucleoside-treated hepatitis B patients. Hepatol 2006, 44: 230A-1A.
-
(2006)
Hepatol
, vol.44
-
-
Dibisceglie, A.1
Lai, C.L.2
Gane, E.3
-
34
-
-
34447124016
-
Adefovir salvage therapy for virologic breakthrough in telbuvidine-treated patients from the GLOBE Study
-
Gane, E., Lai, C.L., Min, A. et al. Adefovir salvage therapy for virologic breakthrough in telbuvidine-treated patients from the GLOBE Study. J Hepatol 2007, 46 (Suppl. 1): S187-8.
-
(2007)
J Hepatol
, vol.46
, Issue.SUPPL. 1
-
-
Gane, E.1
Lai, C.L.2
Min, A.3
-
35
-
-
0035018490
-
Cross-resistance testing of antihepadnaviral compounds using novel recombinant baculoviruses which encode drug-resistant strains of hepatitis B virus
-
Delaney, W.E., Edwards, R., Colledge, D. et al. Cross-resistance testing of antihepadnaviral compounds using novel recombinant baculoviruses which encode drug-resistant strains of hepatitis B virus. Antimicrob Agents Chemother 2001, 45: 1705-13.
-
(2001)
Antimicrob Agents Chemother
, vol.45
, pp. 1705-1713
-
-
Delaney, W.E.1
Edwards, R.2
Colledge, D.3
|