A trial in progress: Gestational diabetes. Treatment with metformin compared with insulin (the Metformin in Gestational Diabetes [MiG] trial)

Diabetes Care

Volumn 30, Issue SUPPL. 2, 2007, Pages

  Rowan, Janet A ^a,b  

^a National Women's Health   (New Zealand)

^b AUCKLAND CITY HOSPITAL   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; METFORMIN;

ARTICLE; BLOOD PRESSURE; CLINICAL TRIAL; DRUG DOSE ESCALATION; DRUG EFFECT; HUMAN; HYPERTENSION; PREECLAMPSIA; PREGNANCY DIABETES MELLITUS; PREGNANT WOMAN; UNSPECIFIED SIDE EFFECT;

ADULT; DIABETES, GESTATIONAL; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; METFORMIN; MORBIDITY; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROSPECTIVE STUDIES;

EID: 34447124329     PISSN: 01495992     EISSN: 01495992     Source Type: Journal    
DOI: 10.2337/dc07-s219     Document Type: Article

References (42)

1. Kjos S, Buchanan T: Gestational diabetes mellitus. N Engl J Med 341:1749-1754, 1999
2. Ben-Haroush B, Yogev Y, Hod M: Epidemiology of gestational diabetes and its association with type 2 diabetes. Diabet Med 21:103-113, 2004
3. Langer O: Is normoglycemia the correct threshold to prevent complications in the pregnant diabetic patient? Diabetes Reviews 4:2-10, 1996
4. Dabelea D, Hanson RL, Lindsay RS, Pettitt DJ, Imperatore G, Gabir MM, Roumain J, Bennett PH, Knowler WC: Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity. Diabetes 49:2208-2211, 2000
5. Silverman BL, Metzger BE, Cho NH, Loeb CA: Impaired glucose tolerance in adolescent offspring of diabetic mothers. Diabetes Care 18:611-617, 1995
6. Boney C, Verma A, Tucker R, Vohr B: Metabolic syndrome in childhood: association with birth weight, maternal obesity and gestational diabetes mellitus. Pediatrics 115:e290-e296, 2005
7. Schaefer-Graf U, Pawliczak J, Passow D, Hartmann R, Rossi R, Buhrer C, Harder T, Plagemann A, Vetter K, Kordonouri O: Birth weight and parental BMI predict overweight in children from mothers with gestational diabetes. Diabetes Care 28:1745-1750, 2005
8. Crowther CA, Hiller JE, Moss JR, McPhee AJ, Jeffries WS, Robinson JS: Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N Engl J Med 352:2477-2486, 2005
9. Langer O, Yogev Y, Most O, Xenakis E: Gestational diabetes: the consequences of not treating. Am J Obstet Gynecol 192:989-997, 2005
10. United Kingdom Prospective Diabetes Study Group (UKPDS) 13: Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years. BMJ 310:83-88, 1995
11. Langer O, Conway DL, Berkus MD, Xenakis EM, Gonzales O: A comparison of glyburide and insulin in women with gestational diabetes. N Engl J Med 343:1134-1138, 2000
12. Kirpichnikov D, McFarlane SI, Sowers JR: Metformin: an update. Ann Intern Med 137:25-33, 2002
13. Hundal RS, Inzucchi SE: Metformin: new understandings, new uses. Drugs 63:1879-1894, 2003
14. Elliott BD, Langer O, Schuessling BA: Human placental glucose uptake and transport are not altered by the oral antihyperglycemic agent metformin. Am J Obstet Gynecol 176:527-530, 1997
15. Elliott BD, Schenker S, Langer O, Johnson R, Prihoda T: Comparative placental transport of oral hypoglycemic agents in humans: a model of human placental drug transfer. Am J Obstet Gynecol 171:653-660, 1994
16. Charles B, Norris R, Xiao X, Hague W: Population pharmacokinetics of metformin in late pregnancy. Ther Drug Monit 28:67-72, 2006
17. th ed. Philadelphia, Lippincott, 2005, p. 1017-1020
18. Coetzee EJ, Jackson WP: Metformin in management of pregnant insulin-independent diabetics. Diabetologia 16:241-245, 1979
19. Coetzee EJ, Jackson WP: Pregnancy in established non-insulin-dependent diabetics. S Afr Med J 58:795-802, 1980
20. Coetzee EJ, Jackson WP: The management of non-insulin-dependent diabetes during pregnancy. Diabetes Res 1:281-287, 1986
21. Hague WM, PMD, Oliver D, Rowan J: Contraindications to use of metformin (Letter). BMJ 326:762a, 2003
22. Hughes R, Rowan J: Pregnancy in women with type 2 diabetes: who takes metformin and what is the outcome? Diabet Med 23:318-322, 2006
23. Hellmuth E, Damm P, Molsted-Pederson L: Oral hypoglycaemic agents in 118 diabetic pregnancies. Diabet Med 17:507-511, 2000
24. Checa M, Requena A, Salvador C, Tur R, Callejo J, Espinos J, Fabregues F, Herrero J: Insulin-sensitising agents: use in pregnancy and as therapy in polycystic ovary syndrome. Hum Reprod Update 11:375-390, 2005
25. Harborne L, Fleming R, Lyall H, Norma J, Sattar N: Descriptive review of the evidence for the use of metformin in polycystic ovary syndrome. Lancet 361:1894-1901, 2003
26. Lord JM, Flight IH, Norman RJ: Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ 327:951-953, 2003
27. Glueck CJ, Wang P, Kobayashi S, Phillips H, Sieve-Smith L: Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome. Fertil Steril 77:520-525, 2002
28. Jakubowicz DJ, Iuorno MJ, Jacubowicz S, Roberts KA, Nestler JE: Effects of metformin on early pregnancy loss in the polycystic ovary syndrome. J Clin Endocrinol Metab 87:524-529, 2002
29. Glueck CJ, Bornovali S, Pranikoff J, Goldenberg N, Dharashivkar S, Wang P: Metformin, pre-eclampsia, and pregnancy outcomes in women with polycystic ovary syndrome. Diabet Med 21:829-836, 2004
30. Vanky E, Salvesen KA, Heimstad R, Fougner KJ, Romunstad P, Carlsen SM: Metformin reduces pregnancy complications without affecting androgen levels in pregnant polycystic ovary syndrome women: results of a randomised study. Hum Reprod 19:1734-1740, 2004
31. Newborn Services Medical Guidelines, Auckland, Auckland District Health Board. http://www.adhb.govt.nz/newborn/Guidelines/Nutrition/HypoglycaemiaManage, 2003
32. Brown MA, Hague WM, Higgins J, McCowan L, Oats J, Peek MJ, Rowan JA, Walters BN: The detection, investigation and management of hypertension in pregnancy: full consensus statement. Aust N Z J Obstet Gynecol 40:139-155, 2000
33. Mello G, Parretti E, Mecacci F, Lucchetti R, Cianciulli D, Lagazio C, Pratesi M, Scarselli G: Anthropometric characteristics of full-term infants: effects of varying degrees of "normal" glucose metabolism. J Perinat Med 25:197-204, 1997
34. Lepercq J, Lahlou N, Timsit J, Girard J, Hauguel de Mouszon S: Macrosomia revisted: ponderal index and leptin delineate subtypes of fetal overgrowth. Am J Obstet Gynecol 181:621-625, 1999
35. Simmons D: Differences in umbilical cord insulin and birth weight in non-diabetic pregnancies of women from different ethnic groups in New Zealand. Diabetologia 37:930-936, 1994
36. Yajnik C, Fall C, Coyaji K, Hirve S, Rao S, Barker D, Joglekar C, Kellingray S: Neonatal anthropometry: the thin-fat Indian baby: The Pune nutritional study. Int J Obes Rel Metab Disord 27:173-180, 2003
37. Rush EC, Puniani K, Valencia ME, Davies PS, Plank LD: Estimation of body fatness from body mass index and bioimpedence: comparison of New Zealand European, Maori, and Pacific Island children. Eur J Clin Nutr 90:1-8, 2003
38. Yajnik C, Lubree HG, Rege SS, Naik SS, Deshpande JA, Joglekar CV, Yudkin JS: Adiposity and hyperinsulinaemia in Indians are present at birth. J Clin Endocrinol Metab 87:5575-5580, 2002
39. Naylor C, Sermer M, Chen E, Sykora K: Cesarean delivery in relation to birth weight and gestational glucose tolerance: pathophysiology or practice style? Toronto Trihospital Gestational Diabetes Investigators. JAMA 275:1165-1170, 1996
40. Hedderson M, Ferrara A, Sacks D: Gestational diabetes mellitus and lesser degrees of pregnancy hyperglycaemia: association with increased risk of spontaneous preterm birth. Obstet Gynecol 102:850-856, 2003
41. Yang X, Hsu-Hage B, Zhang H, Zhang C, Zhang Y, Zhang C: Women with impaired glucose tolerance during pregnancy have significantly poor pregnancy outcomes. Diabetes Care 25:1619-1624, 2002
42. Hofman P, Regan F, Jackson W, Jefferies C, Knight D, Robinson E, Cutfield W: Premature birth and later insulin resistance. N Engl J Med 351:2179-2186, 2004