Proinsulin:insulin and insulin:glucose ratios as predictors of carotid plaque growth: A population-based 7 year follow-up of the Tromsø Study

Diabetologia

Volumn 50, Issue 8, 2007, Pages 1607-1614

  Kronborg, J ^a,c   Johnsen, S H ^b   Njolstad I ^a   Toft, I ^a,b   Eriksen, B O ^b   Jenssen, T ^a,d  

^a UNIVERSITY OF TROMSØ   (Norway)

^b UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^c INNLANDET HOSPITAL TRUST   (Norway)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Atherosclerosis; Carotid; Insulin; Insulin resistance; Plaque; Proinsulin

Indexed keywords

C PEPTIDE; CHOLESTEROL; FIBRINOGEN; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; PROINSULIN;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; ATHEROSCLEROTIC PLAQUE; BLOOD PRESSURE; BODY MASS; CARDIOVASCULAR RISK; CAROTID ARTERY THROMBOSIS; CONTROLLED STUDY; FEMALE; HUMAN; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; MICROALBUMINURIA; PHYSICAL ACTIVITY; POPULATION RESEARCH; PREDICTOR VARIABLE; PRIORITY JOURNAL; SECRETION; SMOKING;

AGED; BLOOD GLUCOSE; CAROTID ARTERY DISEASES; CHI-SQUARE DISTRIBUTION; FEMALE; FOLLOW-UP STUDIES; HEALTH SURVEYS; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; NORWAY; PROINSULIN; RISK FACTORS; SEX FACTORS;

EID: 34447123963     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0715-z     Document Type: Article

References (33)

1. Yudkin JS, May M, Elwood P, Yarnell JW, Greenwood R, Davey Smith G (2002) Concentrations of proinsulin like molecules predict coronary heart disease risk independently of insulin: prospective data from the Caerphilly Study. Diabetologia 45:327-336
2. Haffner SM, D'Agostino R, Mykkänen L et al (1998) Proinsulin and insulin concentrations in relation to carotid wall thickness: Insulin Resistance Atherosclerosis Study. Stroke 29:1498-1503
3. Haffner SM, Mykkänen L, Valdez RA et al (1994) Disproportionately increased proinsulin levels are associated with the insulin resistance syndrome. J Clin Endocrinol Metab 79:1806-1810
4. Perry IJ, Wannamethee SG, Whincup PH, Shaper AG, Walker MK, Alberti KG (1996) Serum insulin and incident coronary heart disease in middle-aged British men. Am J Epidemiol 144:224-234
5. Båvenholm P, Proudler A, Tornvall P et al (1995) Insulin, intact and split proinsulin, and coronary artery disease in young men. Circulation 92:1422-1429
6. Kahn SE, Leonetti DL, Prigeon RL, Boyko EJ, Bergstrom RW, Fujimoto WY (1995) Relationship of proinsulin and insulin with noninsulin-dependent diabetes mellitus and coronary heart disease in Japanese-American men: impact of obesity clinical research center study. J Clin Endocrinol Metab 80:1399-1406
7. Zethelius B, Lithell H, Hales CN, Berne C (2005) Insulin sensitivity, proinsulin and insulin as predictors of coronary heart disease. A population-based 10-year, follow-up study in 70-year old men using the euglycaemic insulin clamp. Diabetologia 48:862-867
8. Lindahl B, Dinesen B, Eliasson M, Røder M, Hallmans G, Stegmayr B (2000) High proinsulin levels precede first-ever stroke in a nondiabetic population. Stroke 31:2936-2941
9. Galloway JA, Hooper SA, Spradlin CT et al (1992) Biosynthetic human proinsulin. Review of chemistry, in vitro and in vivo receptor binding, animal and human pharmacology studies, and clinical trial experience. Diabetes Care 15:666-692
10. Johnsen SH, Mathiesen EB, Fosse E et al (2005) Elevated high-density lipoprotein cholesterol levels are protective against plaque progression: a follow-up study of 1952 persons with carotid atherosclerosis. The Tromsø study. Circulation 112:498-504
11. Spence JD (2002) Ultrasound measurement of carotid plaque as a surrogate outcome for coronary artery disease. Am J Cardiol 89:10B-15B, discussion 1
12. Mykkänen L, Haffner SM, Hales CN, Rönnemaa T, Laakso M (1997) The relation of proinsulin, insulin, and proinsulin-to-insulin ratio to insulin sensitivity and acute insulin response in normoglycemic subjects. Diabetes 46:1990-1995
13. Jørgensen L, Jenssen T, Johnsen SH et al (2007) Albuminuria as risk factor for initiation and progression of carotid atherosclerosis in non-diabetic persons: the Tromso Study. Eur Heart J 28:363-369
14. Jorde R, Burhol PG, Schulz TB et al (1981) The effect of a 34-h fast on the meal-induced rises in plasma GIP, serum insulin, and blood glucose in man. Scand J Gastroenterol 16:109-112
15. Fosse E, Johnsen SH, Stensland-Bugge E et al (2006) Repeated visual and computer-assisted carotid plaque characterization in a longitudinal population-based ultrasound study: the Tromsø study. Ultrasound Med Biol 32:3-11
16. Joakimsen O, Bønaa KH, Stensland-Bugge E (1997) Reproducibility of ultrasound assessment of carotid plaque occurrence, thickness, and morphology. The Tromsø Study. Stroke 28:2201-2207
17. Sayer JW, Marchant B, Gelding SV, Cooper JA, Timmis AD (2000) Autonomic dysfunction is related to impaired pancreatic beta cell function in patients with coronary artery disease. Heart 83:210-216
18. Mohamed-Ali V, Gould MM, Gillies S, Goubet S, Yudkin JS, Haines AP (1995) Association of proinsulin-like molecules with lipids and fibrinogen in non-diabetic subjects-evidence against a modulating role for insulin. Diabetologia 38:1110-1116
19. Gray RP, Mohamed-Ali V, Patterson DL, Yudkin JS (1995) Determinants of plasminogen activator inhibitor-1 activity in survivors of myocardial infarction. Thromb Haemost 73:261-267
20. Haffner SM, Mykkänen L, Stern MP, Valdez RA, Heisserman JA, Bowsher RR (1993) Relationship of proinsulin and insulin to cardiovascular risk factors in nondiabetic subjects. Diabetes 42:1297-1302
21. Festa A, D'Agostino R, Mykkänen L et al (1999) Relative contribution of insulin and its precursors to fibrinogen and PAI-1 in a large population with different states of glucose tolerance. The Insulin Resistance Atherosclerosis Study (IRAS). Arterioscler Thromb Vasc Biol 19:562-568
22. Bokemark L, Wikstrand J, Wedel H, Fagerberg B (2002) Insulin, insulin propeptides and intima-media thickness in the carotid artery in 58-year-old clinically healthy men. The Atherosclerosis and Insulin Resistance study (AIR). Diabet Med 19:144-151
23. Oh JY, Barrett-Connor E, Wedick NM (2002) Sex differences in the association between proinsulin and intact insulin with coronary heart disease in nondiabetic older adults: the Rancho Bernardo Study. Circulation 105:1311-1316
24. Linhart A, Gariepy J, Giral P, Levenson J, Simon A (1996) Carotid artery and left ventricular structural relationship in asymptomatic men at risk for cardiovascular disease. Atherosclerosis 127:103-112
25. Cuspidi C, Lonati L, Macca G et al (2001) Prevalence of left ventricular hypertrophy and carotid thickening in a large selected hypertensive population: impact of different echocardiographic and ultrasonographic diagnostic criteria. Blood Pressure 10:142-149
26. Adams MR, Nakagomi A, Keech A et al (1995) Carotid intima-media thickness is only weakly correlated with the extent and severity of coronary artery disease. Circulation 92:2127-2134
27. Hallerstam S, Larsson PT, Zuber E, Rosfors S (2004) Carotid atherosclerosis is correlated with extent and severity of coronary artery disease evaluated by myocardial perfusion scintigraphy. Angiology 55:281-288
28. Brook RD, Bard RL, Patel S et al (2006) A negative carotid plaque area test is superior to other noninvasive atherosclerosis studies for reducing the likelihood of having underlying significant coronary artery disease. Arterioscler Thromb Vasc Biol 26:656-662
29. Aminbakhsh A, Frohlich J, Mancini GB (1999) Detection of early atherosclerosis with B mode carotid ultrasonography: assessment of a new quantitative approach. Clin Invest Med 22:265-274
30. Huxley R, Barzi F, Woodward M (2006) Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ 332:73-78
31. Levantesi G, Macchia A, Marfisi R et al (2005) Metabolic syndrome and risk of cardiovascular events after myocardial infarction. J Am Coll Cardiol 46:277-283
32. Iglseder B, Cip P, Malaimare L, Ladurner G, Paulweber B (2005) The metabolic syndrome is a stronger risk factor for early carotid atherosclerosis in women than in men. Stroke 36:1212-1217
33. Rajala U, Laakso M, Päivänsalo M, Pelkonen O, Suramo I, Keinänen-Kiukaanniemi S (2002) Low insulin sensitivity measured by both quantitative insulin sensitivity check index and homeostasis model assessment method as a risk factor of increased intima-media thickness of the carotid artery. J Clin Endocrinol Metab 87:5092-5097