Increased brain serotonin turnover in panic disorder patients in the absence of a panic attack: Reduction by a selective serotonin reuptake inhibitor

Stress

Volumn 10, Issue 3, 2007, Pages 295-304

  Esler, Murray ^a   Lambert, Elisabeth ^a   Alvarenga, Marlies ^a   Socratous, Florentia ^a   Richards, Jeff ^b   Barton, David ^a   Pier, Ciaran ^b   Brenchley, Celia ^a   Dawood, Tye ^a   Hastings, Jacqueline ^a   Guo, Ling ^a   Haikerwal, Deepak ^c   Kaye, David ^a   Jennings, Garry ^a   Kalff, Victor ^c   Kelly, Michael ^c   Wiesner, Glen ^a   Lambert, Gavin ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b MONASH UNIVERSITY   (Australia)

^c ALFRED HOSPITAL   (Australia)

Author keywords

5 Hydroxytryptamine; Raphe nucleus; Serotonin transporter polymorphism; Technetium 99 venous sinus SPECT scan

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; CITALOPRAM; MONOAMINE; NORADRENALIN; SEROTONIN; SEROTONIN UPTAKE INHIBITOR;

ADULT; ANALYTIC METHOD; ARTICLE; BLOOD FLOW; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE SEVERITY; GENOTYPE; HUMAN; JUGULAR VEIN; PANIC; PRIORITY JOURNAL; RADIODIAGNOSIS; RAPHE NUCLEUS; SEROTONIN BRAIN LEVEL; SINUS VENOSUS; THERMODILUTION;

ADULT; BRAIN; CASE-CONTROL STUDIES; CATHETERIZATION, CENTRAL VENOUS; CATHETERIZATION, PERIPHERAL; CEREBROVASCULAR CIRCULATION; CITALOPRAM; GENOTYPE; HUMANS; HYDROXYINDOLEACETIC ACID; METHOXYHYDROXYPHENYLGLYCOL; MIDDLE AGED; NOREPINEPHRINE; PANIC DISORDER; RESEARCH DESIGN; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; SEVERITY OF ILLNESS INDEX; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 34447118893     PISSN: 10253890     EISSN: 16078888     Source Type: Journal    
DOI: 10.1080/10253890701300904     Document Type: Article

References (42)

1. Aggarwal A, Esler MD, Lambert GW, Hastings J, Johnston L, Kaye DM. 2002. Norepinephrine turnover is increased in suprabulbar subcortical brain regions and is related to whole-body sympathetic activity in human heart failure. Circulation 105:1031-1033.
2. Alvarenga ME, Richards JC, Lambert G, Esler MD. 2006. Psychophysiological mechanisms in panic disorder: A correlative analysis of noradrenaline spillover, neuronal noradrenaline reuptake, power spectral analysis of heart rate variability, and psychological variables. Psychosom Med 68:8-16.
3. American Psychological Association. 1994. Diagnostic and statistical manual of mental disorders, fourth edition. Washington DC: American Psychiatric Association.
4. Bagdy G. 1998. Serotonin, anxiety, and stress hormones. Focus on 5-HT receptor subtypes, species and gender differences. Ann NY Acad Sci 851:357-363.
5. Brown TA, DiNardo PA, Barlow DH. 1994. Anxiety disorders interview schedule for DSM-IV (ADIS-IV). San Antonio: Graywind Publications.
6. Burghardt NS, Sullivan GM, McEwen BS, Gorman JN, Le Doux JE. 2004. The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: A comparison with tianeptine. Biol Psychiatry 55:1171-1178.
7. Esler M, Jennings G, Korner P, Blombery P, Sacharias N, Leonard P. 1984. Measurement of total and organ-specific norepinephrine kinetics in humans. Am J Physiol 247:E21-E28.
8. Ferrier C, Jennings GL, Eisenhofer G, Lambert G, Cox HS, Kalff V, Kelly M, Esler MD. 1993. Evidence for increased noradrenaline release from subcortical brain regions in essential hypertension. J Hypertens 11:1217-1227.
9. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, Heninger GR, Charney DS. 1989. The Yale-Brown obsessive compulsive scale I. Development, use, and reliability. Arch Gen Psychiatry 46:1006-1011.
10. Graeff FG, Guimaraes FS, De Andrade TG, Deakin JF. 1996. Role of 5-HT in stress, anxiety, and depression. Pharmacol Biochem Behav 54:129-141.
11. Graeff FG, Viana MB, Mora PO. 1997. Dual role of 5-HT in defense and anxiety. Neurosci Biobehav Rev 21:791-799.
12. Greenberg BD, Tolliver TJ, Huang SJ, Li Q, Bengel D, Murphy DL. 1999. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet 88:83-87.
13. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP. 1996. Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-2624.
14. Kennaway DJ, Moyer RW. 1998. Serotonin 5-HT2c agonists mimic the effect of light pulses on circadian rhythms. Brain Res 806:257-270.
15. Kirby LG, Allen AR, Lucki I. 1995. Regional differences in the effects of forced swimming on extracellular levels of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. Brain Res 682:189-196.
16. Lambert GW, Eisenhofer G, Cox HS, Horne M, Kalff V, Kelly M, Jennings GL, Esler MD. 1991. Direct determination of homovanillic acid release from the human brain, an indicator of central dopaminergic activity. Life Sci 49:1061-1072.
17. Lambert GW, Kaye DM, Cox HS, Vaz M, Turner AG, Jennings GL, Esler MD. 1995a. Regional 5-hydroxyindoleacetic acid production in humans. Life Sci 57:255-267.
18. Lambert GW, Kaye DM, Vaz M, Cox HS, Turner AG, Jennings GL, Esler MD. 1995b. Regional origins of 3-methoxy-4-hydroxyphenylglycol in plasma: Effects of chronic sympathetic nervous activation and denervation, and acute reflex sympathetic stimulation. J Auton Nerv Syst 55:169-178.
19. Lambert GW, Kaye DM, Thompson JM, Turner AG, Cox HS, Vaz M, Jennings GL, Wallin BG, Esler MD. 1998. Internal jugular venous spillover of noradrenaline and metabolites and their association with sympathetic nervous activity. Acta Physiol Scand 163:155-163.
20. Lambert GW, Reid C, Kaye DM, Jennings GL, Esler MD. 2002. Effect of sunlight and season on serotonin turnover in the brain. Lancet 360:1840-1842.
21. Lambert GW, Vaz M, Cox HS, Turner AG, Kaye DM, Jennings GL, Esler MD. 1999. Human obesity is associated with a chronic elevation in brain 5-hydroxytryptamine turnover. Clin Sci (Lond) 96:191-197.
22. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL. 1996. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531.
23. Maas JW, Hattox SE, Greene NM, Landis DH. 1979a. 3-Methoxy-4- hydroxyphenethyleneglycol production by human brain in vivo. Science 205:1025-1027.
24. Maas JW, Hattox SE, Martin DM, Landis DH. 1979b. A direct method for determining dopamine synthesis and output of dopamine metabolites from brain in awake animals. J Neurochem 32:839-843.
25. Maron E, Lang A, Tasa G, Liivlaid L, Toru I, Must A, Vasar V, Shlik J. 2005. Associations between serotonin-related gene polymorphisms and panic disorder. Int J Neuropsychopharmacol 8:261-266.
26. Meredith IT, Broughton A, Jennings GL, Esler MD. 1991. Evidence of a selective increase in cardiac sympathetic activity in patients with sustained ventricular arrhythmias. N Engl J Med 325:618-624.
27. Nash JR, Sargen PA, Rabiner EA, Hood SD, Argyropoulos SV, Grasby RM, Nutt DI. 2004. Altered 5HT1A binding in panic disorder demonstrated by positron emission tomography. Eur Neuropsychopharm 14:S322-S323.
28. Neumeister A, Bain E, Nugent AC, Carson RE, Bonne O, Luckenbaugh DA, Eckelman W, Herscovitch P, Charney DS, Drevets WC. 2004. Reduced serotonin type 1A receptor binding in panic disorder. J Neurosci 24:589-591.
29. Norman TR. 1999. The new antidepressants - mechanisms of action. Aust Prescrib 22:106-108.
30. Olivier B, Pattij T, Wood SJ, Oosting R, Sarnyai Z, Toth M. 2001. The 5-HT(1A) receptor knockout mouse and anxiety. Behav Pharmacol 12:439-450.
31. Redmond DE, Jr, Huang YH. 1979. Current concepts. II. New evidence for a locus coeruleus-norepinephrine connection with anxiety. Life Sci 25:2149-2162.
32. Rueter LE, Jacobs BL. 1996. A microdialysis examination of serotonin release in the rat forebrain induced by behavioral/environmental manipulations. Brain Res 739:57-69.
33. Shear MK, Brown TA, Barlow DH, Money R, Sholomskas DE, Woods SW, Gorman JM, Papp LA. 1997. Multicenter collaborative panic disorder severity scale. Am J Psychiatry 154:1571-1575.
34. Shear MK, Rucci P, Williams J, Frank E, Grochocinski V, Vander Bilt J, Houck P, Wang T. 2001. Reliability and validity of the panic disorder severity scale: Replication and extension. J Psychiatr Res 35:293-296.
35. Shimizu N, Take S, Hori T, Oomura Y. 1992. In vivo measurement of hypothalamic serotonin release by intracerebral microdialysis: Significant enhancement by immobilization stress in rats. Brain Res Bull 28:727-734.
36. Singewald N, Kaehler S, Hemeida R, Philippu A. 1997. Release of serotonin in the rat locus coeruleus: Effects of cardiovascular, stressful and noxious stimuli. Eur J Neurosci 9:556-562.
37. Sullivan GM, Oquendo MA, Huang YY, Mann JJ. 2006. Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid levels in women with comorbid depression and panic disorder. Int J Neuropsychopharmacol 9:547-556.
38. Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF, Julius D. 1995. Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature 374:542-546.
39. Tork I. 1990. Anatomy of the serotonergic system. Ann NY Acad Sci 600:9-34.
40. Wilkinson DJ, Thompson JM, Lambert GW, Jennings GL, Schwarz RG, Jefferys D, Turner AG, Esler MD. 1998. Sympathetic activity in patients with panic disorder at rest, under laboratory mental stress, and during panic attacks. Arch Gen Psychiatry 55:511-520.
41. Zhuang X, Gross C, Santarelli L, Compan V, Trillat AC, Hen R. 1999. Altered emotional states in knockout mice lacking 5-HT1A or 5-HT1B receptors. Neuropsychopharmacology 21(Suppl 2):52S-60S.
42. Ziegler DR, Cass WA, Herman JP. 1999. Excitatory influence of the locus coeruleus in hypothalamic-pituitary-adrenocortical axis responses to stress. J Neuroendocrinol 11:361-369.