Hepatitis C virus RNA kinetics: Drug efficacy and the rate of HCV-infected cells loss

World Journal of Gastroenterology

Volumn 13, Issue 21, 2007, Pages 3020-3021

  Dahari, Harel ^a   Perelson, Alan S ^a  

^a LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; RIBAVIRIN; VIRUS RNA;

DRUG EFFICACY; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HOMEOSTASIS; IMMUNE RESPONSE; LETTER; LIVER CIRRHOSIS; MICROBIAL KINETICS; NONHUMAN; STEADY STATE; VIRUS LOAD; VIRUS VIABILITY; VIRUS VIRULENCE;

EID: 34447105804     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v13.i21.3020     Document Type: Letter

References (6)

1. Medeiros-Filho JE, de Carvalho Mello IM, Pinho JR, Neumann AU, de Mello Malta F, da Silva LC, Carrilho FJ. Differences in viral kinetics between genotypes 1 and 3 of hepatitis C virus and between cirrhotic and non-cirrhotic patients during antiviral therapy. World J Gastroenterol 2006; 12: 7271-7277
2. Neumann AU, Lam NP, Dahari H, Gretch DR, Wiley TE, Layden TJ, Perelson AS. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy. Science 1998; 282: 103-107
3. Perelson AS, Herrmann E, Micol F, Zeuzem S. New kinetic models for the hepatitis C virus. Hepatology 2005; 42: 749-754
4. Dahari H, Ribeiro RM, Perelson AS. Triphasic decline of HCV RNA during antiviral therapy. Hepatology 2007
5. Dahari H, Lo A, Ribeiro RM, Perelson AS. Modeling hepatitis C virus dynamics: Liver regeneration and critical drug efficacy. J Theor Biol 2007 Mar 14; [Epub ahead of print]
6. Navasa M, Forns X. Antiviral therapy in HCV decompensated cirrhosis: to treat or not to treat? J Hepatol 2007; 46: 185-188