Structural analysis of photo-degradation in thiazole-containing compounds by LC-MS/MS and NMR

Journal of Pharmaceutical and Biomedical Analysis

Volumn 44, Issue 3 SPEC. ISS., 2007, Pages 763-772

  Wu, Lianming ^a   Hong, Tricia Y ^a   Vogt, Frederick G ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Accurate mass; LC MS MS; NMR; Photo oxygenation; Singlet oxygen; Stress testing of pharmaceuticals; Thiazoles; 4 + 2 Diels Alder cycloaddition

Indexed keywords

4 (4 CHLOROPHENYL)THIAZOL 2 AMINE; 4 CHLORO N (4 METHOXYBENZOYL) 3 FLUOROBENZAMIDE; ENDOPEROXIDE; PROTON; SINGLET OXYGEN; SULFATHIAZOLE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; [4 (4 CHLORO 3 FLUOROPHENYL) 2 [4 (METHYLOXY)PHENYL] 1,3 THIAZOL 5YL]ACETIC ACID;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHROMATOGRAPHY; CYCLOADDITION; DEGRADATION; DEUTERIUM HYDROGEN EXCHANGE; DIELS ALDER REACTION; DRUG ISOLATION; DRUG STRUCTURE; FRAGMENTATION REACTION; IRRADIATION; LIQUID CHROMATOGRAPHY; MOLECULAR WEIGHT; NITROGEN NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOTODEGRADATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RADIOISOTOPE DISTRIBUTION; SOLID STATE; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY;

EID: 34447100848     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2007.02.037     Document Type: Article

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