Production of erythropoietin and multiple cytokines by metanephric adenoma results in erythrocytosis

Pathology International

Volumn 57, Issue 8, 2007, Pages 529-536

  Yoshioka, Kunihiko ^a   Miyakawa, Ayako ^a,c   Ohno, Yoshio ^a   Namiki, Kazunori ^a   Horiguchi, Yutaka ^a   Murai, Masaru ^b   Mukai, Makio ^b   Tachibana, Masaaki ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Erythrocytosis; Erythropoietin; Hematopoietic growth factors; Interleukins; Metanephric adenoma

Indexed keywords

CYTOKINE; ERYTHROPOIETIN; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 6; INTERLEUKIN 8;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SURGERY; CASE REPORT; CHROMOSOME ANALYSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTOSIS; FLOW CYTOMETRY; HUMAN; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; KIDNEY ADENOMA; MALE; METANEPHRIC ADENOMA; MOUSE; NEPHRECTOMY; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; STATISTICAL SIGNIFICANCE; SUPERNATANT; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL CULTURE; TUMOR CELL LINE; TUMOR DIAGNOSIS; TUMOR XENOGRAFT;

ADENOMA; ADOLESCENT; CELL NUCLEUS; CYTOKINES; ERYTHROPOIETIN; GENE EXPRESSION; HUMANS; KIDNEY NEOPLASMS; MALE; NEPHRECTOMY; POLYCYTHEMIA; RNA, MESSENGER; TREATMENT OUTCOME; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 34447093193     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2007.02136.x     Document Type: Article

References (33)

1. Davis CJ Jr., Barton JH, Sesterhenn IA, Mostofi FK. Metanephric adenoma. Clinicopathological study of fifty patients. Am J Surg Pathol 1995 19 : 1101 14.
2. Grignon DJ, Eble JN. Papillary and metanephric adenomas of the kidney. Semin Diagn Pathol 1998 15 : 41 53.
3. Hocking WG. Hematologic abnormalities in patients with renal diseases. Hematol Oncol Clin North Am 1987 1 : 229 60.
4. Shiramizu M, Katsuoka Y, Grodberg J et al. Constitutive secretion of erythropoietin by human renal adenocarcinoma cells in vivo and in vitro. Exp Cell Res 1994 215 : 249 56.
5. Tachibana M, Miyakawa A, Tazaki H et al. Autocrine growth of transitional cell carcinoma of the bladder induced by granulocyte-colony stimulating factor. Cancer Res 1995 55 : 3438 43.
6. Tachibana M, Miyakawa A, Nakashima J et al. Autocrine growth promotion by multiple hematopoietic growth factors in the established renal cell carcinoma line KU-19-20. Cell Tissue Res 2000 301 : 353 67.
7. Kempson SA, McAteer JA, Al-Mahrouq HA, Dousa TP, Dougherty GS, Evan AP. Proximal tubule characteristics of cultured human renal cortex epithelium. J Lab Clin Med 1989 113 : 285 96.
8. Herz F, Schermer A, Koss LG. Short-term culture of epithelial cells from urine of adults. Proc Soc Exp Biol Med 1979 161 : 153 7.
9. Erslev AJ, Caro J. Physiologic and molecular biology of erythropoietin. Med Oncol Tumor Pharmacother 1986 3 : 159 64.
10. Gross AJ, Wolff M, Fandrey J, Miersch WD, Dieckmann KP, Jelkmann W. Prevalence of paraneoplastic erythropoietin production by renal cell carcinomas. Clin Invest 1994 72 : 337 40.
11. Leng HM, Albrecht CF, Kidson SH, Folb PI. Erythropoietin production in anemia associated with experimental cancer. Exp Hematol 1999 27 : 806 10.
12. Cook A, Lorenzo AJ, Salle JL et al. Pediatric renal cell carcinoma: Single institution 25-year case series and initial experience with partial nephrectomy. J Urol 2006 175 : 1456 60.
13. Dreicer R, Donovan J, Benda JA, Lund J, Degowin RL. Paraneoplastic erythrocytosis in a young adult with an erythropoietin-producing Wilms' tumor. Am J Med 1992 93 : 229 30.
14. Lal A, Rice A, al Mahr M, Kern IB, Marshall GM. Wilms tumor associated with polycythemia: Case report and review of the literature. J Pediatr Hematol Oncol 1997 19 : 263 5.
15. Kuhne M, Sidler D, Hofer S, Lugli A, Ludwig C. Challenging manifestations of malignancies. Case 1. Polycythemia and high serum erythropoietin level as a result of hemangioblastoma. J Clin Oncol 2004 22 : 3639 40.
16. Mirand EA. Extra-renal and renal control of erythropoietin production. Ann N Y Acad Sci 1968 149 : 94 106.
17. Arcasoy MO, Amin K, Vollmer RT, Jiang X, Demark-Wahnefried W, Haroon ZA. Erythropoietin and erythropoietin receptor expression in human prostate cancer. Mod Pathol 2005 18 : 421 30.
18. Beguin Y. Erythropoiesis and erythropoietin in multiple myeloma. Leuk Lymphoma 1995 18 : 413 21.
19. Fandrey J, Bunn HF. In vivo and in vitro regulation of erythropoietin mRNA: Measurement by competitive polymerase chain reaction. Blood 1993 81 : 617 23.
20. Murphy GP, Mirand EA, Sinks LF, Allen JE, Staubitz WJ. Ectopic production of erythropoietin in Wilms tumor patients in relation to clinical stage and disease activity. J Urol 1975 113 : 230 33.
21. Sakisaka S, Watanabe M, Tateishi H et al. Erythropoietin production in hepatocellular carcinoma cells associated with polycythemia: Immunohistochemical evidence. Hepatology 1993 18 : 1357 62.
22. Kitayama S, Fujii Y, Kihara K. Urothelial cancer producing granulocyte colony-stimulating factor: Possible induction of splenomegaly. Urology 2004 63 : 377 8.
23. Tachibana M, Murai M. G-CSF production in human bladder cancer and its ability to promote autocrine growth: A review. Cytokines Cell Mol Ther 1998 4 : 113 20.
24. Frede S, Fandrey J, Pagel H, Hellwig T, Jelkmann W. Erythropoietin gene expression is suppressed after lipopolysaccharide or interleukin-1 beta injections in rats. Am J Physiol 1997 273 : R1067 71.
25. Jelkmann W. Proinflammatory cytokines lowering erythropoietin production. J Interferon Cytokine Res 1998 18 : 555 9.
26. Jelkmann WE, Fandrey J, Frede S, Pagel H. Inhibition of erythropoietin production by cytokines. Implications for the anemia involved in inflammatory states. Ann NY Acad Sci 1994 718 : 300 309 discussion 309-11.
27. Wetzler M, Estrov Z, Talpaz M, Markowitz A, Gutterman JU, Kurzrock R. Granulocyte-macrophage colony-stimulating factor as a cause of paraneoplastic leukaemoid reaction in advanced transitional cell carcinoma. J Intern Med 1993 234 : 417 20.
28. Jardin F, Vasse M, Debled M et al. Intense paraneoplastic neutrophilic leukemoid reaction related to a G-CSF-secreting lung sarcoma. Am J Hematol 2005 80 : 243 5.
29. Kan M, Tamura M, Kojima K, Naruo S, Kanayama H, Kagawa S. A case of renal cell carcinoma producing granulocyte-macrophage colony-stimulating factor. J Urol 1996 155 : 2022 3.
30. Melhem MF, Meisler AI, Saito R, Finley GG, Hockman HR, Koski RA. Cytokines in inflammatory malignant fibrous histiocytoma presenting with leukemoid reaction. Blood 1993 82 : 2038 44.
31. Papac RJ, Poo-Hwu WJ. Renal cell carcinoma: A paradigm of lanthanic disease. Am J Clin Oncol 1999 22 : 223 31.
32. Kim HL, Belldegrun AS, Freitas DG et al. Paraneoplastic signs and symptoms of renal cell carcinoma: Implications for prognosis. J Urol 2003 170 : 1742 6.
33. Laski ME, Vugrin D. Paraneoplastic syndromes in hypernephroma. Semin Nephrol 1987 7 : 123 30.