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Lipsky PE, van der Heijde DM, St Clair EW, et al. Infliximab and methotrexate in the treatment of rheumatoid arthritis; Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. N Engl J Med 2000; 343:1594-1602.
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Baert F, Norman M, Vermeire S, et al. Influence of immunogenicity on the long-term efficacy of infliximab in Cohn's disease. N Engl J Med 2003; 348:601-608. This study nicely defines the likelihood of developing idiotypic antibodies and their impact on the therapeutic response.
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Gómez-Reino JJ, Carmona L, Rodriguez Valverde V, et al. Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors may predispose to significant increase in tuberculosis risk. Arthr Rheum 2003; 48:2122-2127. This report validates what had been theoretical concerns over TNF-α antagonism and the propensity to develop serious infectious complications. Data from this report support not only the direct impact of these agents on mycobacterial disease, but the increased incidence associated with the underlying disease process.
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Arthr Rheum
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