Can curcumin cure cystic fibrosis?

New England Journal of Medicine

Volumn 351, Issue 6, 2004, Pages 606-608

  Zeitlin, Pamela ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CURCUMIN; TRANSMEMBRANE CONDUCTANCE REGULATOR; CALCIUM; CFTR PROTEIN, HUMAN; CHLORIDE CHANNEL; ENZYME INHIBITOR;

ARTICLE; BIOTECHNOLOGY; CHLORIDE CONDUCTANCE; CYSTIC FIBROSIS; DRUG EFFECT; ENDOPLASMIC RETICULUM; GENETIC DISORDER; HUMAN; NUTRIENT; PRIORITY JOURNAL; ANIMAL; GENETICS; METABOLISM; MOUSE; MOUSE MUTANT; MUTATION;

ANIMALS; CALCIUM; CHLORIDE CHANNELS; CURCUMIN; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; HUMANS; MICE; MICE, KNOCKOUT; MUTATION;

EID: 3442895327     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMcibr041584     Document Type: Article

References (5)

1. Egan ME, Pearson M, Weiner SA, et al. Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science 2004;304:600-2.
2. Zeitlin PL, Diener-West M, Rubenstein RC, Boyle MP, Lee CK, Brass-Ernst L. Evidence of CFTR function in cystic fibrosis after systemic administration of 4-phenylbutyrate. Mol Ther 2002;6:119-26.
3. Illek BL, Zhang L, Lewis NC, Moss RB, Dong JY, Fischer H. Defective function of the cystic fibrosis-causing missense mutation G551D is recovered by genistein. Am J Physiol 1999;277:C833-C839.
4. Wilschanski M, Yahav Y, Yaacov Y, et al. Gentamicin-induced correction of CFTR function in patients with cystic fibrosis and CFTR stop mutations. N Engl J Med 2003;349:1433-41.
5. Yerxa BR, Sabater JR, Davis CW, et al. Pharmacology of INS37217 [P(1)-(uridine 5′)-P(4)-(2′-deoxycytidine 5′)tetraphosphate, tetrasodium salt], a next-generation P2Y(2) receptor agonist for the treatment of cystic fibrosis. J Pharmacol Exp Ther 2002;302: 871-80.