No association of the mitochondrial DNA A12308G polymorphism with increased risk of stroke in patients with the A3243G mutation

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 75, Issue 8, 2004, Pages 1204-1205

  Deschauer, M ^a,b   Chinnery, P F ^a   Schaefer, A M ^a   Turnbull, D M ^a   Taylor, R W ^a   Zierz, S ^b   Shanske, S ^c   DiMauro, S ^c   Mojamaa, K ^d   Wilichowski, E ^e   Thorburn, D R ^f  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c College of Physicians and Surgeons ^*  (United States)

^d UNIVERSITY OF OULU   (Finland)

^e UNIVERSITY OF GÖTTINGEN   (Germany)

^f ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

ARTICLE; CAUCASIAN; CONTROLLED STUDY; DNA POLYMORPHISM; DNA SEQUENCE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; STROKE;

EID: 3442876759     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: 10.1136/jnnp.2003.026278     Document Type: Article

References (5)

1. Chinnery PF, Howell N, Lightowlers RN, et al. Molecular pathology of MELAS and MERRF. The relationship between mutation load and clinical phenotypes. Brain 1997;120:1713-21.
2. Pulkes T, Sweeney MG, Hanna MG. Increased risk of stroke in patients with the A12308G polymorphism in mitochondria. Lancet 2000;356:2068-9.
3. Howell N. Human mitochondrial diseases: answering questions and questioning answers. Int Rev Cytol 1999;186:49-116.
4. Majamaa K, Finnilà S, Turkka J, et al. Mitochondrial DNA haplogroup U as a risk factor for occipital stroke in migraine. Lancet 1998;352:455-6.
5. Iizuka T, Sakai F, Suzuki N, et al. Neuronal hyperexcitability in stroke-like episodes of MELAS syndrome. Neurology 2002;59:816-24.