CP-64131, an aminobenzazepine with cytokine-like properties, stimulates human neutrophil functions through the p38-MAPK pathway

Journal of Leukocyte Biology

Volumn 76, Issue 2, 2004, Pages 477-483

  Anderson, Marsha S ^a,c   Knall, Cindy ^b,e   Thurman, Gail ^a   Mann, Don ^d   Cusack, Nancy ^d   Johnson, Gary L ^b,c,f   Ambruso, Daniel R ^a,c  

^a Bonfils Blood Center   (United States)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d PFIZER INC   (United States)

^e LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^f UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

ERK1 2; FMLP; GM CSF

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BENZAZEPINE DERIVATIVE; CD11B ANTIGEN; CP 64131; CYTOKINE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; CELL POLARITY; CELL STIMULATION; CELL TYPE; CONFERENCE PAPER; CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NEUTROPHIL; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; ANTIGENS, CD11B; BENZAZEPINES; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; NEUTROPHILS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SUPEROXIDES; TIME FACTORS;

EID: 3442875824     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0903422     Document Type: Conference Paper

References (31)

1. Mollinedo, F., Borregaard, N., Boxer, L. A. (1999) Novel trends in neutrophil structure, function and development. Immunol. Today 20, 535-537.
2. Ambruso, D. R., Knall, C., Abell, A. N., Panepinto, J., Kurkchubasche, A., Thurman, G., Gonzalez-Aller, C., Hiester, A., deBoer, M., Harbeck, R. J., Oyer, R., Johnson, G. L., Roos, D. (2000) Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation. Proc. Natl. Acad. Sci. USA 97, 4654-4659.
3. Malech, H. L., Nauseef, W. M. (1997) Primary inherited defects in neutrophil function: etiology and treatment. Semin. Hematol. 34, 279-290.
4. Downey, G. P., Fukushima, T., Fialkow, L., Waddell, T. K. (1995) Intracellular signaling in neutrophil priming and activation. Semin. Cell Biol. 6, 345-356.
5. Widmann, C., Gibson, S., Jarpe, M. B., Johnson, G. L. (1999) Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol. Rev. 79, 143-180.
6. Worthen, G. S., Avdi, N., Buhl, A. M., Suzuki, N., Johnson, G. L. (1994) fMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase. J. Clin. Invest. 94, 815-823 (see comments).
7. Knall, C., Young, S., Nick, J. A., Buhl, A. M., Worthen, G. S., Johnson, G. L. (1996) Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils. J. Biol. Chem. 271, 2832-2838.
8. Knall, C., Worthen, G. S., Johnson, G. L. (1997) Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases. Proc. Natl. Acad. Sci. USA 94, 3052-3057.
9. McLeish, K. R., Knall, C., Ward, R. A., Gerwins, P., Coxon, P. Y., Klein, J. B., Johnson, G. L. (1998) Activation of mitogen-activated protein kinase cascades during priming of human neutrophils by TNF-α and GM-CSF. J. Leukoc. Biol. 64, 537-545.
10. Nick, J. A., Avdi, N. J., Gerwins, P., Johnson, G. L., Worthen, G. S. (1996) Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide. J. Immunol. 156, 4867-4875.
11. Nick, J. A., Avdi, N. J., Young, S. K., Knall, C., Gerwins, P., Johnson, G. L., Worthen, G. S. (1997) Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and fMLP. J. Clin. Invest. 99, 975-986.
12. Avdi, N. J., Nick, J. A., Whitlock, B. B., Billstrom, M. A., Henson, P. M., Johnson, G. L., Worthen, G. S. (2001) Tumor necrosis factor-{α} activation of the c-Jun N-terminal kinase pathway in human neutrophils. Integrin involvement in a pathway leading from cytoplasmic tyrosine kinases to apoptosis. J. Biol. Chem. 276, 2189-2199.
13. Avdi, N. J., Winston, B. W., Russel, M., Young, S. K., Johnson, G. L., Worthen, G. S. (1996) Activation of MEKK by formyl-methionyl-leucylphenylalanine in human neutrophils. Mapping pathways for mitogen-activated protein kinase activation. J. Biol. Chem. 271, 33598-33606.
14. El Benna, J., Han, J., Park, J. W., Schmid, E., Ulevitch, R. J., Babior, B. M. (1996) Activation of p38 in stimulated human neutrophils: phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK. Arch. Biochem. Biophys. 334, 395-400.
15. Cusack, N. A., Petras, C. F., Natoli, E. J., Mann, D. W. (1997) CP-64131 induces functional activities in human PMNs via activation of the p38 MAP kinase. J. Allergy Clin. Immunol. 99, S290.
16. Mann, D. W., Cusack, N. A., Petras, C. F., Natoli, E. J. (1997) Reversal of doxorubicin-induced myelosuppression by CP-64131 in dogs. J. Allergy Clin. Immunol. 99, S187.
17. Rosenthal, J., Thurman, G. W., Cusack, N., Peterson, V. M., Malech, H. L., Ambruso, D. R. (1996) Neutrophils from patients after bum injury express a deficiency of the oxidase components p47-phox and p67-phox. Blood 88, 4321-4329.
18. Widmann, C., Gerwins, P., Johnson, N. L., Jarpe, M. B., Johnson, G. L. (1998) MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis. Mol. Cell. Biol. 18, 2416-2429.
19. Yujiri, T., Ware, M., Widmann, C., Oyer, R., Russell, D., Chan, E., Zaitsu, Y., Clarke, P., Tyler, K., Oka, Y., Fanger, G. R., Henson, P., Johnson, G. L. (2000) MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-κ B activation. Proc. Natl. Acad. Sci. USA 97, 7272-7277.
20. Leavey, P. J., Sellins, K. S., Thurman, G., Elzi, D., Hiester, A., Silliman, C. C., Zerbe, G., Cohen, J. J., Ambruso, D. R. (1998) In vivo treatment with granulocyte colony-stimulating factor results in divergent effects on neutrophil functions measured in vitro. Blood 92, 4366-4374.
21. Gomez-Cambronero, J., Colasanto, J. M., Huang, C. K., Sha'afi, R. I. (1993) Direct stimulation by tyrosine phosphorylation of microtubule-associated protein (MAP) kinase activity by granulocyte-macrophage colony-stimulating factor in human neutrophils. Biochem. J. 291, 211-217.
22. Lee, J. C., Kassis, S., Kumar, S., Badger, A., Adams, J. L. (1999) p38 Mitogen-activated protein kinase inhibitors - mechanisms and therapeutic potentials. Pharmacol. Ther. 82, 389-397.
23. Lazar, D. F., Wiese, R. J., Brady, M. J., Mastick, C. C., Waters, S. B., Yamauchi, K., Pessin, J. E., Cuatrecasas, P., Saltiel, A. R. (1995) Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin. J. Biol. Chem. 270, 20801-20807.
24. Dang, P. M., Morel, F., Gougerot-Pocidalo, M. A., Benna, J. E. (2003) Phosphorylation of the NADPH oxidase component p67(PHOX) by ERK2 and P38MAPK: selectivity of phosphorylated sites and existence of an intramolecular regulatory domain in the tetratricopeptide-rich region. Biochemistry 42, 4520-4526.
25. Knall, C., Johnson, G. L. (1998) G-protein regulatory pathways: rocketing into the twenty-first century. J. Cell. Biochem. Suppl. 30-31, 137-146.
26. Harrison, T., Graham, F., Williams, J. (1977) Host-range mutants of adenovirus type 5 defective for growth in HeLa cells. Virology 77, 319-329.
27. Benard, V., Bohl, B. P., Bokoch, G. M. (1999) Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. J. Biol. Chem. 274, 13198-13204.
28. Waterman, W. H., Molski, T. F., Huang, C. K., Adams, J. L., Sha'afi, R. I. (1996) Tumour necrosis factor-α-induced phosphorylation and activation of cytosolic phospholipase A2 are abrogated by an inhibitor of the p38 mitogen-activated protein kinase cascade in human neutrophils. Biochem. J. 319, 17-20.
29. Dana, R., Leto, T. L., Malech, H. L., Levy, R. (1998) Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase. J. Biol. Chem. 273, 441-445.
30. Prigmore, E., Ahmed, S., Best, A., Kozma, R., Manser, E., Segal, A. W., Lim, L. (1995) A 68-kDa kinase and NADPH oxidase component p67phox are targets for Cdc42Hs and Rac1 in neutrophils. J. Biol. Chem. 270, 10717-10722.
31. Bagrodia, S., Cerione, R. A. (1999) Pak to the future. Trends Cell Biol. 9, 350-355.