Natural antisense transcripts of Alzheimer's disease associated genes

DNA Sequence - Journal of DNA Sequencing and Mapping

Volumn 17, Issue 2, 2006, Pages 170-173

  Guo, Jin Hu ^a,b   Cheng, Hai Peng ^a   Yu, Long ^b   Zhao, Shouyuan ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b FUDAN UNIVERSITY   (China)

Author keywords

Alzheimer's disease; APH1A; APP; BACE2; Natural antisense transcript; Tau

Indexed keywords

ANTERIOR PHARYNX DEFECTIVE 1 PROTEIN; BETA SECRETASE; CD147 ANTIGEN; NICASTRIN; PRESENILIN 1; PRESENILIN 2; SYNUCLEIN; TAU PROTEIN; ALPHA SYNUCLEIN; AMYLOID PRECURSOR PROTEIN; APH1A PROTEIN, HUMAN; ASPARTIC PROTEINASE; BACE2 PROTEIN, HUMAN; COMPLEMENTARY RNA; MAPT PROTEIN, HUMAN; MEMBRANE PROTEIN; PEPTIDE HYDROLASE; SECRETASE;

ALZHEIMER DISEASE; ARTICLE; GENE EXPRESSION; GENE FUNCTION; GENETIC TRANSCRIPTION; HUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; TRANSLATION REGULATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; RNA INTERFERENCE;

ALPHA-SYNUCLEIN; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANTIGENS, CD147; ASPARTIC ENDOPEPTIDASES; BASE SEQUENCE; GENE EXPRESSION REGULATION; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PEPTIDE HYDROLASES; RNA INTERFERENCE; RNA, ANTISENSE; TAU PROTEINS; TRANSCRIPTION, GENETIC;

EID: 34347406397     PISSN: 10425179     EISSN: 10292365     Source Type: Journal    
DOI: 10.1080/10425170600609165     Document Type: Article

References (15)

1. Alfano G, Vitiello C, Caccioppoli C, Caramico T, Carola A, Szego MJ, et al. 2005. Natural antisense transcripts associated with genes involved in eye development. Hum Mol Genet 14:913-923.
2. Cummings JL. 2004. Alzheimer's disease. N Engl J Med 351:56-67.
3. Drewes G. 2004. MARKing tau for tangles and toxicity. Trends Biochem Sci 29:548-555.
4. Eckstein F. 2005. Small non-coding RNAs as magic bullets. Trends Biochem Sci 30:445-452.
5. Farzan M, Schnitzler CE, Vasilieva N, Leung D, Choe H. 2000. BACE2, a beta-secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein. Proc Natl Acad Sci USA 97:9712-9717.
6. Ho L, Sharma N, Blackman L, Festa E, Reddy G, Pasinetti GM. 2005. From proteomics to biomarker discovery in Alzheimer's disease. Brain Res Brain Res Rev 48:360-369.
7. Lehner B, Williams G, Campbell RD, Sanderson CM. 2002. Antisense transcripts in the human genome. Trends Genet 18:63-65.
8. Liu G, Garrett MR, Men P, Zhu X, Perry G, Smith MA. 2005. Epub ahead of print Nanoparticle and other metal chelation therapeutics in Alzheimer disease. Biochim Biophys Acta.
9. McCaffrey AP, Meuse L, Pham TT, Conklin DS, Hannon GJ, Kay MA. 2002. RNA interference in adult mice. Nature 418:38-39.
10. Mikolaenko I, Pletnikova O, Kawas CH, O'Brien R, Resnick SM, Crain B, Troncoso JC. 2005. Alpha-synuclein lesions in normal aging Parkinson disease, and Alzheimer disease: Evidence from the Baltimore longitudinal study of aging. BLSA 64:156-162.
11. Prescott EM, Proudfoot NJ. 2002. Transcriptional collision between convergent genes in budding yeast. Proc Natl Acad Sci USA 99:8796-8801.
12. Vassar R. 2004. BACE1: The beta-secretase enzyme in Alzheimer's disease. J Mol Neurosci 23:105-114.
13. Wood JG, Mirra SS, Pollock NJ, Binder LI. 1986. Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau). Proc Natl Acad Sci USA 83:4040-4043.
14. Yelin R, Dahary D, Sorek R, Levanon EY, Goldstein O, Shoshan A, et al. 2003. Widespread occurrence of antisense transcription in the human genome. Nat Biotechnol 21:379-386.
15. Zhou S, Zhou H, Walian PJ, Jap BK. 2005. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production. Proc Natl Acad Sci USA 102:7499-7504.