-
2
-
-
33749246867
-
Epidermal growth factor receptor-targeted molecular therapeutics for head and neck squamous cell carcinoma
-
Egloff AM, Grandis J: Epidermal growth factor receptor-targeted molecular therapeutics for head and neck squamous cell carcinoma. Expert Opin. Ther. Targets 10(5), 639-647 (2006).
-
(2006)
Expert Opin. Ther. Targets
, vol.10
, Issue.5
, pp. 639-647
-
-
Egloff, A.M.1
Grandis, J.2
-
3
-
-
33847622161
-
Targeting receptor tyrosine kinases and their signal transduction routes in head and neck cancer
-
Cruz JJ, Ocana A, Del Barco E, Pandielia A: Targeting receptor tyrosine kinases and their signal transduction routes in head and neck cancer. Ann. Oncol. 18(3), 421-430 (2006).
-
(2006)
Ann. Oncol
, vol.18
, Issue.3
, pp. 421-430
-
-
Cruz, J.J.1
Ocana, A.2
Del Barco, E.3
Pandielia, A.4
-
4
-
-
31344480403
-
Advances in molecular diagnostics and therapeutics in head and neck cancer
-
Chai RL, Grandis JR: Advances in molecular diagnostics and therapeutics in head and neck cancer. Curr. Treat. Options Oncol. 7(1), 3-11 (2006).
-
(2006)
Curr. Treat. Options Oncol
, vol.7
, Issue.1
, pp. 3-11
-
-
Chai, R.L.1
Grandis, J.R.2
-
5
-
-
1542288028
-
Identification of tyrosine kinases overexpressed in head and neck cancer
-
Lin HS, Berry GJ, Fee WE Jr, Terris DJ, Sun Z: Identification of tyrosine kinases overexpressed in head and neck cancer. Arch. Otolaryngol. Head Neck Surg. 130 (3), 311-316 (2004).
-
(2004)
Arch. Otolaryngol. Head Neck Surg
, vol.130
, Issue.3
, pp. 311-316
-
-
Lin, H.S.1
Berry, G.J.2
Fee Jr, W.E.3
Terris, D.J.4
Sun, Z.5
-
7
-
-
18344390418
-
ERBB receptors and cancer: The complexity of targeted inhibitors
-
Hynes NE, Lane HA: ERBB receptors and cancer: the complexity of targeted inhibitors. Nat. Rev. Cancer 5(5), 341-354 (2005).
-
(2005)
Nat. Rev. Cancer
, vol.5
, Issue.5
, pp. 341-354
-
-
Hynes, N.E.1
Lane, H.A.2
-
8
-
-
10044266668
-
The epidermal growth factor receptor signaling network in head and neck carcinogenesis and implications for targeted therapy
-
Pomerantz RG, Grandis JR: The epidermal growth factor receptor signaling network in head and neck carcinogenesis and implications for targeted therapy. Semin. Oncol. 31(6), 734-743 (2004).
-
(2004)
Semin. Oncol
, vol.31
, Issue.6
, pp. 734-743
-
-
Pomerantz, R.G.1
Grandis, J.R.2
-
9
-
-
0346645692
-
The role of epidermal growth factor receptor in head and neck squamous, cell carcinoma
-
Pomerantz RG, Grandis JR: The role of epidermal growth factor receptor in head and neck squamous, cell carcinoma. Curr Oncol. Rep. 5(2), 140-146 (2003).
-
(2003)
Curr Oncol. Rep
, vol.5
, Issue.2
, pp. 140-146
-
-
Pomerantz, R.G.1
Grandis, J.R.2
-
10
-
-
33748188459
-
Epidermal growth factor receptor biology in head and neck cancer
-
Kalyankrishna S, Grandis JR: Epidermal growth factor receptor biology in head and neck cancer. J. Clin. Oncol. 24(17), 2666-2672(2006).
-
(2006)
J. Clin. Oncol
, vol.24
, Issue.17
, pp. 2666-2672
-
-
Kalyankrishna, S.1
Grandis, J.R.2
-
11
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordelia R et al.: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350(21), 2129-2139 (2004).
-
(2004)
N. Engl. J. Med
, vol.350
, Issue.21
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordelia, R.3
-
12
-
-
33947422073
-
Dual EGFR and mTOR targeting in squamous cell carcinoma models, and development of early markers of efficacy
-
Jimeno A, Kuiesza P, Wheelhouse J et al.: Dual EGFR and mTOR targeting in squamous cell carcinoma models, and development of early markers of efficacy. Br. J. Cancer 96(6), 952-959 (2007).
-
(2007)
Br. J. Cancer
, vol.96
, Issue.6
, pp. 952-959
-
-
Jimeno, A.1
Kuiesza, P.2
Wheelhouse, J.3
-
13
-
-
0036024532
-
The role of c-erbB receptors and ligands in head and neck squamous cell carcinoma
-
O-charoenrat P, Rhys-Evans PH, Modjtahedi H, Eccles SA: The role of c-erbB receptors and ligands in head and neck squamous cell carcinoma. Oral Oncol. 38(7), 627-640 (2002).
-
(2002)
Oral Oncol
, vol.38
, Issue.7
, pp. 627-640
-
-
O-charoenrat, P.1
Rhys-Evans, P.H.2
Modjtahedi, H.3
Eccles, S.A.4
-
14
-
-
33645130990
-
Signaling through ERBB receptors: Multiple layers of diversity and control
-
Warren CM, Landgraf R: Signaling through ERBB receptors: multiple layers of diversity and control. Cell. Signal. 18(7), 923-933 (2006).
-
(2006)
Cell. Signal
, vol.18
, Issue.7
, pp. 923-933
-
-
Warren, C.M.1
Landgraf, R.2
-
15
-
-
2442701289
-
The ErbB/HER receptor protein-tyrosine kinases and cancer
-
Roskoski R Jr: The ErbB/HER receptor protein-tyrosine kinases and cancer. Biochem. Biophys. Res. Commun. 319(1), 1-11 (2004).
-
(2004)
Biochem. Biophys. Res. Commun
, vol.319
, Issue.1
, pp. 1-11
-
-
Roskoski Jr, R.1
-
16
-
-
7244232712
-
Frequent overexpression of multiple ErbB receptors by head and neck squamous cell carcinoma contrasts with rare antibody immunity in patients
-
Bel R, Budillon A, Masuelil L et al.: Frequent overexpression of multiple ErbB receptors by head and neck squamous cell carcinoma contrasts with rare antibody immunity in patients. J. Pathol. 204(3), 317-325 (2004).
-
(2004)
J. Pathol
, vol.204
, Issue.3
, pp. 317-325
-
-
Bel, R.1
Budillon, A.2
Masuelil, L.3
-
17
-
-
33746084112
-
Signaling via ErbB2 and ErbB3 associates with resistance and epidermal growth factor receptor (EGFR) amplification with sensitivity to EGFR inhibitor gefitinib in head and neck squamous cell carcinoma cells
-
Erjaia K, Sundvall M, Junttila TT et al.: Signaling via ErbB2 and ErbB3 associates with resistance and epidermal growth factor receptor (EGFR) amplification with sensitivity to EGFR inhibitor gefitinib in head and neck squamous cell carcinoma cells. Clin. Cancer Res. 12(13), 4103-4111 (2006).
-
(2006)
Clin. Cancer Res
, vol.12
, Issue.13
, pp. 4103-4111
-
-
Erjaia, K.1
Sundvall, M.2
Junttila, T.T.3
-
18
-
-
32144433159
-
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
-
Bonner JA, Harari PM, Giralt J et al.: Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N. Engl. J. Med. 354(6), 567-578 (2006).
-
(2006)
N. Engl. J. Med
, vol.354
, Issue.6
, pp. 567-578
-
-
Bonner, J.A.1
Harari, P.M.2
Giralt, J.3
-
19
-
-
0033906634
-
Structure and function of the type 1 insulin-like growth factor receptor
-
Adams TE, Epa VC, Garrett TP, Ward CW: Structure and function of the type 1 insulin-like growth factor receptor. Cell. Mol. Life Sci. 57(7), 1050-1093 (2000).
-
(2000)
Cell. Mol. Life Sci
, vol.57
, Issue.7
, pp. 1050-1093
-
-
Adams, T.E.1
Epa, V.C.2
Garrett, T.P.3
Ward, C.W.4
-
20
-
-
33847271170
-
Insulin-like growth factor-1 receptor and ligand targeting in head and neck squamous cell carcinoma
-
Slomiany MG, Black LA, Kibbey MM et al.: Insulin-like growth factor-1 receptor and ligand targeting in head and neck squamous cell carcinoma. Cancer Lett. 248(2), 269-279 (2006).
-
(2006)
Cancer Lett
, vol.248
, Issue.2
, pp. 269-279
-
-
Slomiany, M.G.1
Black, L.A.2
Kibbey, M.M.3
-
21
-
-
3042673048
-
Serum levels of insulin growth factor (IGF-I) and IGF-binding protein predict risk of second primary tumors in patients with head and neck cancer
-
Wu X, Zhao H, Do KA et al.: Serum levels of insulin growth factor (IGF-I) and IGF-binding protein predict risk of second primary tumors in patients with head and neck cancer. Clin. Cancer Res. 10(12 Pt 1), 3988-3995 (2004).
-
(2004)
Clin. Cancer Res
, vol.10
, Issue.12 PART 1
, pp. 3988-3995
-
-
Wu, X.1
Zhao, H.2
Do, K.A.3
-
22
-
-
12144285705
-
In vivo antitumor activity of NVP-AEW541: A novel, potent, and selective inhibitor of the IGF-IR kinase
-
García-Echeverría C, Pearson MA, Marti A et al.: In vivo antitumor activity of NVP-AEW541: a novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cells 5(3), 231-237 (2004).
-
(2004)
Cancer Cells
, vol.5
, Issue.3
, pp. 231-237
-
-
García-Echeverría, C.1
Pearson, M.A.2
Marti, A.3
-
23
-
-
33646828939
-
Targeting cancer cells - more pathways, more inhibitors, more trails. Highlights of 9th Annual Drug Discovery Technology World Congress. Boston. MA, USA, 8-13 August 2004
-
Mariani SM: Targeting cancer cells - more pathways, more inhibitors, more trails. Highlights of 9th Annual Drug Discovery Technology World Congress. Boston. MA, USA, 8-13 August 2004. Med Gen Med 6(4). 22 (2004).
-
(2004)
Med Gen Med
, vol.6
, Issue.4
, pp. 22
-
-
Mariani, S.M.1
-
24
-
-
33847041527
-
Insulin-like growth factor-1 receptor signaling blockade combined with radiation
-
Allen GW, Saba C, Armstrong EA et al.: Insulin-like growth factor-1 receptor signaling blockade combined with radiation. Cancer Res. 67(3), 1155-1162 (2007).
-
(2007)
Cancer Res
, vol.67
, Issue.3
, pp. 1155-1162
-
-
Allen, G.W.1
Saba, C.2
Armstrong, E.A.3
-
25
-
-
0142227019
-
Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
-
Luo J, Manning BD, Cantley LC: Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 4(4), 257-262 (2003).
-
(2003)
Cancer Cell
, vol.4
, Issue.4
, pp. 257-262
-
-
Luo, J.1
Manning, B.D.2
Cantley, L.C.3
-
26
-
-
0034234924
-
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
-
Sekulic A, Hudson CC, Homme JL et al.: A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 60(13), 3504-3513 (2000).
-
(2000)
Cancer Res
, vol.60
, Issue.13
, pp. 3504-3513
-
-
Sekulic, A.1
Hudson, C.C.2
Homme, J.L.3
-
27
-
-
27544505190
-
Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck
-
Amornphimoltham P, Patel V, Sodhi A et al.: Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck. Cancer Res. 65(21), 9953-9961 (2005).
-
(2005)
Cancer Res
, vol.65
, Issue.21
, pp. 9953-9961
-
-
Amornphimoltham, P.1
Patel, V.2
Sodhi, A.3
-
28
-
-
33645084781
-
PIK3CA mutations in head and neck squamous cell carcinoma
-
Qiu W, Schonleben F, Li X et al.: PIK3CA mutations in head and neck squamous cell carcinoma. Clin. Cancer Res. 12(5), 1441-1446 (2006).
-
(2006)
Clin. Cancer Res
, vol.12
, Issue.5
, pp. 1441-1446
-
-
Qiu, W.1
Schonleben, F.2
Li, X.3
-
29
-
-
33750364266
-
PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma
-
Kozaki K, Imoto I, Pimkhaokham A et al.: PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma. Cancer Sri. 97(12), 1351-1358 (2006).
-
(2006)
Cancer Sri
, vol.97
, Issue.12
, pp. 1351-1358
-
-
Kozaki, K.1
Imoto, I.2
Pimkhaokham, A.3
-
30
-
-
0035949699
-
AKT plays a central role in tumorigenesis
-
Testa JR, Bellacosa A: AKT plays a central role in tumorigenesis. Proc. Natl Acad. Sci. USA 98(20), 10983-10985 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, Issue.20
, pp. 10983-10985
-
-
Testa, J.R.1
Bellacosa, A.2
-
31
-
-
3042531148
-
Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: A potential target for UCN-01
-
Amornphimoltham P, Sriuranpong V, Patel V et al.: Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01. Clin. Cancer Res. 10(12 Pt 1), 4029-4037 (2004).
-
(2004)
Clin. Cancer Res
, vol.10
, Issue.12 PART 1
, pp. 4029-4037
-
-
Amornphimoltham, P.1
Sriuranpong, V.2
Patel, V.3
-
32
-
-
0036057475
-
The cell cycle as a target for cancer therapy: Basic and clinical findings with the small molecule inhibitors flavopiridol and UCN-01
-
Senderowicz AM: The cell cycle as a target for cancer therapy: basic and clinical findings with the small molecule inhibitors flavopiridol and UCN-01. Oncologist 7(Suppl. 3), 12-19 (2002).
-
(2002)
Oncologist
, vol.7
, Issue.SUPPL. 3
, pp. 12-19
-
-
Senderowicz, A.M.1
-
33
-
-
1642323740
-
Protein kinase inhibitors: Insights into drug design from structure
-
Noble MEM, Endicott JA, Johnson LN: Protein kinase inhibitors: insights into drug design from structure. Science 303(5665), 1800-1805 (2004).
-
(2004)
Science
, vol.303
, Issue.5665
, pp. 1800-1805
-
-
Noble, M.E.M.1
Endicott, J.A.2
Johnson, L.N.3
-
34
-
-
33746784004
-
Growth inhibition of head and neck squamous cell carcinoma by imatinib mesylate (Gleevec)
-
Chu HR, Ongkeko WM. Diaz A et al: Growth inhibition of head and neck squamous cell carcinoma by imatinib mesylate (Gleevec). Cancer Ther. 3, 515-524 (2005).
-
(2005)
Cancer Ther
, vol.3
, pp. 515-524
-
-
Chu, H.R.1
Ongkeko, W.M.2
Diaz, A.3
-
35
-
-
0034693877
-
Role of Src expression and activation in human cancer
-
Irby RB, Yeatman TJ: Role of Src expression and activation in human cancer. Oncogene 19(49), 5636-5642 (2000).
-
(2000)
Oncogene
, vol.19
, Issue.49
, pp. 5636-5642
-
-
Irby, R.B.1
Yeatman, T.J.2
-
36
-
-
0037150728
-
Src in cancer: Deregulation and consequences for cell behaviour
-
Frame MC: Src in cancer: deregulation and consequences for cell behaviour. Biochim. Biophys. Acta 1602(2), 114-130 (2002).
-
(2002)
Biochim. Biophys. Acta
, vol.1602
, Issue.2
, pp. 114-130
-
-
Frame, M.C.1
-
37
-
-
7944236785
-
Src family kinases, key regulators of signal transduction
-
Parsons SJ, Parsons JT: Src family kinases, key regulators of signal transduction. Oncogene 23(48), 7906-7909 (2004).
-
(2004)
Oncogene
, vol.23
, Issue.48
, pp. 7906-7909
-
-
Parsons, S.J.1
Parsons, J.T.2
-
38
-
-
26444468152
-
Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells
-
Johnson FM, Saigal B, Taipaz M, Donato NJ: Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells. Clin. Cancer Res. 11(19 Pt 1), 6924-6932 (2005).
-
(2005)
Clin. Cancer Res
, vol.11
, Issue.19 PART 1
, pp. 6924-6932
-
-
Johnson, F.M.1
Saigal, B.2
Taipaz, M.3
Donato, N.J.4
-
39
-
-
0042357187
-
Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck
-
Xi S, Zhang Q, Dyer KF et al.: Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. J. Biol. Chem. 278(34), 31574-31583 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, Issue.34
, pp. 31574-31583
-
-
Xi, S.1
Zhang, Q.2
Dyer, K.F.3
-
40
-
-
0038581774
-
Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system
-
Sriuranpong V, Park JI. Amornphimoltham P et al.: Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system. Cancer Res. 63(11), 2948-2956 (2003).
-
(2003)
Cancer Res
, vol.63
, Issue.11
, pp. 2948-2956
-
-
Sriuranpong, V.1
Park, J.I.2
Amornphimoltham, P.3
-
41
-
-
0026446102
-
Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
-
Plate KH, Breier G, Welch HA, Risau W: Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature 359(6398). 845-848 (1992).
-
(1992)
Nature
, vol.359
, Issue.6398
, pp. 845-848
-
-
Plate, K.H.1
Breier, G.2
Welch, H.A.3
Risau, W.4
-
42
-
-
0037386774
-
Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase
-
Ciardiello F, Caputo R, Damiano V et al.: Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase. Clin. Cancer Res. 9(4), 1546-1556 (2003).
-
(2003)
Clin. Cancer Res
, vol.9
, Issue.4
, pp. 1546-1556
-
-
Ciardiello, F.1
Caputo, R.2
Damiano, V.3
-
43
-
-
28444474907
-
O-100 ZD6474 plus docetaxel In patients with previously treated NSCLC: Results of a randomized, placebo-controlled Phase II trial
-
Herbst R, Johnson B, Rowbottom J et al.: O-100 ZD6474 plus docetaxel In patients with previously treated NSCLC: results of a randomized, placebo-controlled Phase II trial. Lung Cancer 49(Suppl. 2), S35-S36 (2005).
-
(2005)
Lung Cancer
, vol.49
, Issue.SUPPL. 2
-
-
Herbst, R.1
Johnson, B.2
Rowbottom, J.3
|