Stereochemistry as a determinant of the anti-leukemic potency of halopyridyl and thiazolyl thiourea compounds

Letters in Drug Design and Discovery

Volumn 4, Issue 5, 2007, Pages 318-326

  Venkatachalam, Taracad K ^a,b   Vassilev, Alexi O ^a   Benyunov, Alexi ^a   Grigoriants, Olga O ^a   Tibbles, Heather E ^a   Uckun, Fatih M ^a  

^a Parker Hughes Cancer Center   (United States)

^b Paradigm Pharmaceuticals   (United States)

Author keywords

Caspase; Leukemia; Stereochemistry; Thiourea; Zebrafish

Indexed keywords

ANTILEUKEMIC AGENT; CASPASE 3; CYCLOHEXYLAMINE; CYCLOHEXYLETHYLTHIAZOLYLTHIOUREA DERIVATIVE; HALOPYRIDYL DERIVATIVE; HI 509; HI 510; HI 511; HI 512; HI 513; N (1 ALPHA METHYLBENZYL) N' [2 (5 BROMOPYRIDYL)]THIOUREA; N [1 (1 ALPHA METHYLBENZYL)] N' [2 (5 CHLOROPYRIDYL)]THIOUREA; N [1 (1 CYCLOHEXYLETHYL)] N [2 (5 BROMOPYRIDYL)]THIOUREA; N [1 (1 CYCLOHEXYLETHYL)] N [2 (5 CHLOROPYRIDYL)]THIOUREA; PYRIDINE DERIVATIVE; THIAZOLE DERIVATIVE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CANCER CHEMOTHERAPY; DRUG DETERMINATION; DRUG POTENCY; DRUG SYNTHESIS; ENANTIOMER; ENZYME ACTIVATION; HUMAN; MICROTUBULE ASSEMBLY; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY; ZEBRA FISH;

EID: 34347401396     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018007780867870     Document Type: Article

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