R-(-)-N-alkyl-11-hydroxy-10-hydroxymethyl- and 10-methyl-aporphines as 5-HT1A receptor ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 15, 2007, Pages 4128-4130

  Si, Yu Gui ^a   Gardner, Matthew P ^a   Tarazi, Frank I ^a   Baldessarini, Ross J ^a   Neumeyer, John L ^a  

^a MCLEAN HOSPITAL   (United States)

Author keywords

5 HT1A receptor ligands; Aporphines; Binding affinities

Indexed keywords

10 METHYL APORPHINE DERIVATIVE; APORPHINE DERIVATIVE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; N ALKYL 11 HYDROXY 10 HYDROMETHYL APORPHINE DERIVATIVE; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; FOREBRAIN; NONHUMAN; RAT; RECEPTOR BINDING;

ANIMALS; APORPHINES; LIGANDS; PROTEIN BINDING; RATS; RECEPTOR, SEROTONIN, 5-HT1A;

RATTUS;

EID: 34347400366     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.05.057     Document Type: Article

References (13)

1. Baldessarini R.J., Kula N.S., Zong R., and Neumeyer J.L. Eur. J. Pharmacol. 254 (1994) 199
2. Zhang A., Zhang Y., Branfman A.R., Baldessarini R.J., and Neumeyer J.L. J. Med. Chem. 50 (2007) 171
3. Schaus J.M., Titus R.D., Foreman M.M., Mason N.R., and Truex L.L. J. Med. Chem. 33 (1990) 600
4. Cannon J.G., Mohan P., Bojarski J., Long J.P., Bhatnagar R.K., Leonard P.A., Flynn J.R., and Chatterjee T.K. J. Med. Chem. 31 (1988) 313
5. Cannon J.G., Moe S.T., and Long J.P. Chirality 3 (1991) 19
6. Hedberg M.H., Johansson A.M., and Hacksell U. J. Chem. Soc., Chem. Commun. (1992) 845
7. Hedberg M.H., Johansson A.M., Nordvall G., Yliniemela ̈ A., Li H.-B., Martin A.R., Hjorth S., Unelius L., Sundell S., and Hacksell U. J. Med. Chem. 38 (1995) 647
8. Hedberg M.H., Jansen J.M., Nordvall G., Hjorth S., Unelius L., and Johansson A.M. J. Med. Chem. 39 (1996) 3491
9. Coop A., Lewis J.W., and Rice K.C. J. Org. Chem. 61 (1996) 6774
10. Csutoras C., Zhang A., Zhang K., Kula N.S., Baldessarini R.J., and Neumeyer J.L. Bioorg. Med. Chem. 12 (2004) 3553
11. 2: C, 77.64; H, 7.49; N, 4.53. Found: C, 77.03; H, 7.52; N, 4.50.
12. Kula N.S., Baldessarini R.J., Kebabian J.W., Bakthavachalam V., and Xu L. Eur. J. Pharmacol. 331 (1997) 333
13. Menon M.K., Clark W.G., and Neumeyer J.L. Eur. J. Pharm. 52 (1978) 1