Antimicrobial activity of rationally designed amino terminal modified peptides

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 15, 2007, Pages 4343-4346

  Bisht, Gopal Singh ^a,b   Rawat, Diwan S ^b   Kumar, Anil ^a   Kumar, Rita ^a   Pasha, Santosh ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^b UNIVERSITY OF DELHI   (India)

Author keywords

Antimicrobial activity; Cationic antimicrobial peptides; Cinnamic acid; Hemolytic activity; Modified peptides

Indexed keywords

PEPTIDE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIBIOTIC SENSITIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; ERYTHROCYTE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTEIN STRUCTURE; PROTEIN SYNTHESIS;

ANTI-BACTERIAL AGENTS; GRAM-POSITIVE BACTERIA; HEMOLYSIS; HUMANS; MICROBIAL SENSITIVITY TESTS; PEPTIDES;

BACTERIA (MICROORGANISMS); MAMMALIA; NEGIBACTERIA; POSIBACTERIA;

EID: 34347396940     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.05.015     Document Type: Article

References (24)

1. Neu H.C. Science 257 (1992) 1064
2. Travis J. Science 264 (1994) 360
3. Zasloff M. Nature 415 (2002) 389
4. Andreu D., and Rivas L. Biopolymers (Peptide Sci.) 47 (1998) 415
5. Hancock R.E., and Lehrer R. Trends Biotechnol. 16 (1998) 82
6. van't H.W., Veerman E.C., Helmerhorst E.J., and Amerongen A.V. Biol. Chem. 382 (2001) 597
7. Yeaman M.R., and Yount N.Y. Pharmacol. Rev. 55 (2003) 27
8. Coates A., Hu Y., Bax R., and Page C. Nat. Rev. Drug Discov. 1 (2002) 895
9. Moellering Jr. R.C. J. Infect. Chemother. 9 (2003) 8
10. Hancock R.E. Lancet 349 (1997) 418
11. Sitaram N., and Nagaraj R. Curr. Pharm. Des. 8 (2002) 727
12. Tossi A., Sandri L., and Giangaspero A. Biopolymers 55 (2000) 4
13. Strøm M.B., Haug B.E., Skar M.L., Stensen W., Stiberg T., and Svendsen J.S. J. Med. Chem. 46 (2003) 1567
14. Strøm M.B., Rekdal Ø., and Svendsen J.S. J. Pept. Sci. 8 (2002) 36
15. Deber C.M., and Goto N.K. Nat. Struct. Biol. 3 (1996) 815
16. Wimley W.C., and White S.H. Nat. Struct. Biol. 3 (1996) 842
17. Takeichi K. Chem. Abstr. 57 (1962) 2669
18. Narsimhan B., Belsare D., Pharande D., Mourya V., and Dhake A. Eur. J. Med. Chem. 39 (2004) 827
19. Story S.C., and Aldrich J.V. Int. J. Pept. Prot. Res. 39 (1992) 87
20. Kaiser E., Colescott R.L., Bossinger C.D., and Cook P.I. Anal. Biochem. 34 (1970) 595
21. Friedrich C.L., Moyles D., Beveridge T.J., and Hancock R.E. Antimicrob. Agents Chemother. 44 (2000) 2086
22. Yang S.T., Yub Shin S.Y., Kim Y.C., Kim Y., Hahm K.S., and Kim J.I. Biochem. Biophys. Res. Commun. 296 (2002) 1044
23. 414 nm in PBS)] × 100. Zero percentage and 100% hemolysis were determined in PBS and 0.1% Triton X-100, respectively.
24. Rydlo T., Rotem S., and Mor A. Antimicrob. Agents Chemother. 50 (2006) 490