Selective and potent in vitro antimalarial activities found in four microbial metabolites

Journal of Antibiotics

Volumn 60, Issue 3, 2007, Pages 220-222

  Ui, Hideaki ^b   Ishiyama, Aki ^a   Sekiguchi, Hitomi ^a   Namatame, Miyuki ^a   Nishihara, Aki ^a   Takahashi, Yoko ^b   Shiomi, Kazuro ^b   Otoguro, Kazuhiko ^a   Ömura, Satoshi ^b  

^a KITASATO INSTITUTE   (Japan)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

Antimalarial antibiotics; Drug resistant strain; Hedamycin; Plasmodium falciparum; Simaomicin ; Triacsin

Indexed keywords

ANTIMALARIAL AGENT; ARTEMETHER; ARTEMISININ; CHLOROQUINE; HEDAMYCIN; SIMAOMICIN ALPHA; TRIACSIN C; TRIACSIN D; UNCLASSIFIED DRUG; ANTHRAQUINONE DERIVATIVE; ISOQUINOLINE DERIVATIVE; TRIAZENE DERIVATIVE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; ANIMAL; CHEMISTRY; DRUG EFFECT; DRUG RESISTANCE; DRUG SENSITIVITY; LETTER;

PLASMODIUM FALCIPARUM;

ANIMALS; ANTHRAQUINONES; ANTIMALARIALS; DRUG RESISTANCE; ISOQUINOLINES; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; TRIAZENES;

EID: 34347396818     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2007.27     Document Type: Article

References (15)

1. Otoguro K, Kohana A, Manabe C, Ishiyama A, Ui H, Shiomi K, Yamada H, Ōmura S. Potent antimalarial activities of polyether antibiotic, X-206. J Antibiot 54: 658-663 (2001)
2. Otoguro K, Ishiyama A, Ui H, Kobayashi M, Manabe C, Yan G, Takahashi Y, Tanaka H, Yamada H, Ōmura S. In vitro and in vivo antimalarial activities of the monoglycoside polyether antibiotic, K-41 against drug resistant strains of Plasmodia. J Antibiot 55: 832-834 (2002)
3. Otoguro K, Ui H, Ishiyama A, Arai N, Kobayashi M, Takahashi Y, Masuma R, Shiomi K, Yamada H, Ōmura S. In vitro antimalarial activities of the microbial metabolites. J Antibiot 56: 322-324 (2003)
4. Otoguro K, Ui H, Ishiyama A, Kobayashi M, Togashi H, Takahashi Y, Masuma R, Tanaka H, Tomoda H, Yamada H, Ōmura S. In vitro and in vivo antimalarial activities of a non-glycoside 18-member macrolide antibiotic, borrelidin, against drug-resistant strains of Plasmodia. J Antibiot 56: 727-729 (2003)
5. Otoguro K, Ishiyama A, Kobayashi M, Sekiguchi H, Izuhara T, Sunazuka T, Tomoda H, Yamada H, Ōmura S. In vitro and in vivo antimalarial activities of a carbohydrate antibiotic, prumycin, against drug-resistant strains of Plasmodia. J Antibiot 57: 400-402 (2004)
6. Séquin U. The structure of the antibiotic hedamycin-II. Comparison of hedamycin and kidamycin. Tetrahedron 34: 761-767 (1978)
7. Maiese WM, Korshalla J, Goodman Torrey MJ, Kantor S, Labeda DP, Greenstein M. Simaomicin (LL-D42067), a novel antibiotic from Actinomadura madurae. I. Taxonomy, fermentation and biological activity. J Antibiot 43: 1059-1063 (1990)
8. Ōmura S, Tomoda H, Xu QM, Takahashi Y, Iwai Y. Triacsins, new inhibitor of acyl-CoA synthetase produced by Streptomyces. J Antibiot 39: 1211-1218 (1986)
9. Phrutivorapongkul A, Ichino C, Ruangrungsi N, Ishiyama A, Sekiguchi H, Namatame M, Kiyohara H, Otoguro K. Yamada H, Ōmura S. Anti-Plasmodial activity of bisbenzylisoquinoline alkaloids from Michelia figo leaves. Thai J. Health Res. 20: 121-128 (2006)
10. Bradner WT, Heinemann B, Gourevitch A. Hedamycin, a new antitumor antibiotic. II. Biological properties. Antimicrob Agents Chemother 1966: 613-618 (1967)
11. Arai M, Sato H, Kobayashi H, Suganuma M, Kawabe T, H. Tomoda H, Ōmura S. Selective inhibition of bleomycin-induced G2 cell cycle checkpoint by simaomicin α. Biochem Biophys Res Commun 317: 817-822 (2004)
12. Arnot DE, Gull K. The Plasmodium cell-cycle: facts and questions. Ann Trop Med Parasitol 92: 361-365 (1998)
13. Kim J-H, Lewin TM. Coleman RA. Expression and characterization of recombinant rat acyl-CoA synthetases 1, 4, and 5. Selective inhibiton by triacsin C and thiazoidinediones. J Biol Chem 276: 24667-24673 (2001)
14. Tomoda H, Igarashi K, Cyong JC, Ōmura S. Evidence for and essential role of long chain acyl-CoA synthetase in animal cell proliferation. J Biol Chem 266: 4214-4219 (1991)
15. Matesanz F, Durán-Chica I, Alcina A. The Plasmodium falciparum fatty acyl-CoA synthetase family (PfACS) and differential stage-specific expression in infected erythrocytes. Mol Biochem Parasitol 126: 109-112 (2003)