Substrate and inhibitor specificity of Mycobacterium avium dihydrofolate reductase

FEBS Journal

Volumn 274, Issue 13, 2007, Pages 3286-3298

  Böck, Ronnie A ^a,b   Soulages, Jose L ^a   Barrow, William W ^a  

^a OKLAHOMA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF NAMIBIA   (Namibia)

Author keywords

Dihydrofolate reductase; Mycobacteria; Site directed mutagenesis; Trimethoprim

Indexed keywords

ASPARTIC ACID; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; FOLIC ACID ANTAGONIST; LEUCINE; MUTANT PROTEIN; RESIN; TRIMETHOPRIM;

ARTICLE; BACTERIAL STRAIN; BINDING AFFINITY; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME BINDING; ENZYME KINETICS; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; GROWTH; MOLECULAR INTERACTION; MUTANT; MYCOBACTERIUM AVIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS; SUBSTITUTION REACTION; WILD TYPE;

ANTI-INFECTIVE AGENTS, URINARY; ASPARTIC ACID; ENZYME INHIBITORS; ESCHERICHIA COLI; INHIBITORY CONCENTRATION 50; KINETICS; LEUCINE; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MUTATION; MYCOBACTERIUM AVIUM; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY; TETRAHYDROFOLATE DEHYDROGENASE; TRIMETHOPRIM;

CORYNEBACTERINEAE; ESCHERICHIA COLI; MYCOBACTERIUM AVIUM;

EID: 34347393462     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2007.05855.x     Document Type: Article

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