Exposition of newborn rats to bacterial endotoxin impairs pancreatic enzyme secretion at adult age

Journal of Physiology and Pharmacology

Volumn 58, Issue 2, 2007, Pages 287-302

  Jaworek, Jolanta ^a,b   Nawrot Porabka K ^a   Leja Szpak, A ^a   Szklarczyk, J ^a   Macko, M ^a   Bonior, J ^a   Stachura, J ^a   Konturek, S J ^a   Pawlik, W W ^a  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

LPS; Pancreatic acini; Pancreatic amylase secretion; RT PCR; Suckling rat

Indexed keywords

AMYLASE; BACTERIUM LIPOPOLYSACCHARIDE; CERULETIDE; CHOLECYSTOKININ A RECEPTOR; ENDOTOXIN; ESCHERICHIA COLI ENDOTOXIN; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; MESSENGER RNA; PANCREAS ENZYME; SALMONELLA ENDOTOXIN;

AMYLASE BLOOD LEVEL; AMYLASE RELEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT FISTULA; CONTROLLED STUDY; ENDOTOXEMIA; ENZYME RELEASE; ESCHERICHIA COLI; GENE EXPRESSION; HISTOLOGY; NEWBORN; NEWBORN PERIOD; NONHUMAN; PANCREAS ACINUS; PANCREAS EXOCRINE INSUFFICIENCY; PANCREAS FISTULA; PANCREAS JUICE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALMONELLA TYPHI; SIGNAL TRANSDUCTION; SUCKLING;

AMYLASES; ANIMALS; ANIMALS, NEWBORN; CAERULEIN; DOSE-RESPONSE RELATIONSHIP, DRUG; LIPOPOLYSACCHARIDES; ORGAN SIZE; PANCREAS; RATS; RATS, WISTAR; RECEPTOR, CHOLECYSTOKININ A;

EID: 34347381100     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Van Amersfoort ES, Van Berkel TJC, Kuiper J. Receptors, mediators and mechanisms involved in the bacterial sepsis and septic shock. Clin Microbiol Rev 2003; 16: 374-414.
2. Jaenschke H, Smidt CW. Cell adhesion and migration.III. Leukocyte adhesion and transmigration in the liver vasculature. Am J Physiol 1997; 273: G1169-G1173.
3. Qezado ZM, Hoffman DW, Winkelstein JA, et al. The third component of complement protects against Escherichia coli endotoxin-induced shock and multiple organ failure. J Exp Med 1994; 179: 569-578.
4. Hiemstra PS, Eisenbauer PB, Harwig SS, Van den Barselaar MT, Van Furth R, Lehrer RI. Antimicrobial proteins of murine macrophages. Infect Immun 1993; 61: 3038-3046.
5. Lin NT, Yang FL, Lee RP, Peng TC, Chen HI. Inducible nitric oxide synthase mediates cytokine release: the time course in conscious and septic rats. Life Sci 2006; 78: 1038-1043.
6. Victor VM, Rocha M, Esplugues JV, De la Fuente JM. Role of radicals in sepsis: antioxidant therapy. Curr Pharm Des 2005; 11: 3141-3158.
7. Schunamm RR, Zweinger J. A novel acute phase marker: lipopolysaccharide binding protein (LBP). Clin Chem Lab Med 1999; 37: 271-274.
8. Steel D, Whitehead AS. The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein. Immunol Today 1994; 15: 81-88.
9. Giamarellos-Bourboulis EJ, Nikou GC, Matsaggoura M, et al. Alterations of systemic endotoxemia over the course of acute edematous pancreatitis. Correlation to the advent of an infection? Pancreatology 2003; 3: 323-328.
10. Wang X, Wu L, Wu K, Zhang R, Dong Y. Roles of endotoxin-related signaling molecules in the progression of acute necrotizing pancreatitis in mice. Pancreas 2005; 31: 251-257.
11. Fortunato F, Deng X, Gates LK, et al. Pancreatic response to endotoxin after chronic alcohol exposure: switch from apoptosis to necrosis. Am J Physiol 2006; 290: G232-G241.
12. Jaworek J, Jachimczak B, Bonior J, et al. Protective role of endogenous nitric oxide (NO) in lipopolysaccharide-induced pancreatic damage. (a new experimental model of acute pancreatitis). J Physiol Pharmacol 2000; 51: 85-102.
13. Vaccaro MI, Calvo EL, Suburo AM, Sordelli DO, Lanosa G, Iovanna JL. Lipopolysaccaride directly affects pancreatic acinar cells. Dig Dis Sci 2000; 45: 915-926.
14. Dembiński A, Warzecha Z, Ceramowicz P, et al. Effect of ischemic preconditioning on pancreatic regeneration and pancreatic expression of vascular endothelial growth factor and platelet-growth factor A in ischemia/reperfusion incuced pancreatitis. J PhysiolPharmacol 2006, 57:39-58.
15. Bonior J, Jaworek J, Konturek SJ, Pawlik WW. Increase of heat shock protein gene expression by melatonin in AR42J cells. J Physiol Pharmacol 2006, 57:471-482.
16. Vaccaro MI, Dagrosa M, Mora MI, Tiscornia OM, Sordelli DO. The effect of chronic intraperitoneal infusion of bacterial endotoxin on exocrine pancreatic function in rats. Int J Pancreatol 1996; 19: 49-54.
17. Garret-Cox RG, Pierro A, Spitz L, Eaton S. Body temperature and heat production in suckling rat endotoxemia: beneficial effects of glutamine. J Pediatr Surg 2003; 38: 37-44.
18. Orellana RA, O'Connor PM, Nguyen HV, et al. Endotoxemia reduces skeletal muscle protein synthesis in neonates. Am J Physiol Endocrinol Metab 2002; 283: E909-E916.
19. Jaworek J, Nawrot K, Konturek SJ, et al. Melatonin and its precursor; L-tryptophan: influence on pancreatic amylase secretion in vivo and in vitro. J Pineal Res 2004; 36: 156-164.
20. Bernfeld P. Amylases alpha and beta. Meth Enzymol 1955; 5: 139-148.
21. Yang L. Sameshima H, Ikeda T, Ikenoue T. Lipopolysaccharide administration enhances hypoxic-ischemic brain damage in newborn rats. J Obstet Gynaecol Res 2004; 2: 142-147.
22. Devlin LA, Nguyen MD, Figueroa E, Gordon LE, Feldhoff PW, Lassiter HA. Effects of endotoxin administration and cerebral hypoxia-ischemia on complement activity and local transcriptional regulation in neonatal rats. Neurosci Lett 2005; 239: 109-113.
23. Li Y, Hao Y, Owyang C. Evidence for autoregulation of cholecystokinin secretion during diversion of bile pancreatic juice in rats. Gastroenterology 1995; 109: 231-238.
24. Li Y, Zhu J, Owyang C. Electrical physiological evidence for high and low affinity vagal CCK-A receptors. Am J Physiol 1999; 277 (2Pt 1): G469-G477.
25. Griesbacher T, Rainer I, Heineman A, Groisman D. Hemodynamic and exocrine effects of caerulein at submaximal levels on the rat pancreas: role of cholecystokinin receptor subtypes. Pancreatology 2006; 6: 65-75.
26. Owyang C. Logsdon CD. New insights into neurohormonal regulation of pancreatic secretion. Gastroenterology 2004; 127: 957-69.
27. Williams JA, Sans MD, Tashiro M, Schafer C, Bragado MJ, Dabrowski A. Cholecystokinin activates a variety of intracellular signal transduction mechanisms in rodent pancreatic acinar cells. Pharmacol Toxicol 2002; 91: 297-303.
28. Li Y, Wu XY, Owyang C. Serotonin and cholecystokinin synergistically stimulates rat vagal primary afferent neurons. J Physiol 2004; 559(Pt 2): 651-662.
29. Ji B, Bi Y, Simeone D, Mortensen RM, Logsdon CD. Human pancreatic acinar cells do not respond to cholecystokinin. Pharmacol Toxicol 2002; 91: 327-332.
30. Reubi JC, Waser B, Gugger M, Friess H, et al. Distribution of CCK1 and CCK2 receptors in normal and diseased human pancreatic tissue. Gastroenterology 2003; 125: 98-106.