Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 15, 2007, Pages 4374-4377

  Keith, John M ^a   Gomez, Leslie A ^a   Barbier, Ann J ^a   Wilson, Sandy J ^a   Boggs, Jamin D ^a   Lord, Brian ^a   Mazur, Curt ^a   Aluisio, Leah ^a   Lovenberg, Timothy W ^a   Carruthers, Nicholas I ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Histamine H3; Microdialysis; Serotonin transporter

Indexed keywords

1 BROMO 3 CHLOROPROPANE; 6 HETEROARYL PYRROLIDINO TETRAHYDROISOQUINOLINE DERIVATIVE; HETEROCYCLIC COMPOUND; HISTAMINE H3 RECEPTOR ANTAGONIST; QUINOLINE DERIVATIVE; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; HUMAN; IN VIVO STUDY; NONHUMAN;

ANIMALS; BLOOD-BRAIN BARRIER; HISTAMINE H1 ANTAGONISTS; MICE; PYRROLIDINES; RECEPTORS, HISTAMINE H3; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 34347380862     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.03.043     Document Type: Article

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