Synthesis, antitumor and antitubercular evaluation of certain new xanthenone and acridinone analogs

Arzneimittel-Forschung/Drug Research

Volumn 49, Issue 3, 1999, Pages 259-266

  Abadi, Ashraf H ^a   El Subbagh, Hussein I ^a   Al Khamees, Hamad A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

9 Xanthenones; 9 Acridinones; Antitubercular activity; Antitumor activity; Synthesis

Indexed keywords

1,2,4 TRICHLORO 9 (10H) ACRIDINONE; 4 (N1 ACETYL)SULPHANILAMIDOMETHYL 6 CHLORO 9 XANTHENONE; 4 (N1 AMIDINO)SULPHANILAMIDOMETHYL 6 CHLORO 9 XANTHENONE; 6 CHLORO 4 PHENYLTHIOMETHYL 9 XANTHENONE; ACRIDONE DERIVATIVE; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG CONFORMATION; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; LC 50; MOUSE; NONHUMAN;

EID: 0033002344     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300411     Document Type: Article

References (24)

1. Denny, W. A., Atwell, G. J., Rewcastle, G. W. et al., J. Med. Chem. 30, 658 (1987)
2. Rewcastle, G. W., Atwell, G. J., Baguley, B. C. et al., J. Med. Chem. 32, 793 (1989)
3. Faulds, D., Balfour, J. A., Chrisp, P. et al., J. Med. Chem. 32, 793 (1991)
4. Krapcho, A. P., Petry, M. E., Getahun, Z. et al., J. Med. Chem. 37, 828 (1994)
5. Baguley, B. C., Denny, W. A., Atwell, G. J. et al., Med. Chem. 24, 520 (1981)
6. Denny, W. A., Anticancer Drug Res. 4, 241 (1989)
7. Atwell, G. J., Bos, C. D., Baguley, B. C. et al., J. Med. Chem. 31, 1048 (1988)
8. Baguley, B. C., Denny, W. A., Atwell, G. J. et al., Cancer Res. 44, 3245 (1984)
9. Hollingshead, L. M., Faulds, D., Drugs 42, 690 (1991)
10. Tempezyk, A., Tarasiuk, J., Ossowsk, T. et al., Anticancer Drug Res. 2, 371 (1987)
11. Cordien, J. F., Vincent, M., Touraine, R., Sem. Hosp. 57, 1752 (1981)
12. Yamada, H., Nakahara, Y., Aoki, Y. et al., Intern. Med. 31, 740 (1992)
13. Dhabhar, B. N., Malhotra, H., Hedge, U. et al., J. Assoc. Physicians India 39, 783 (1991)
14. Hirana, T., Koeffler, H. P., Blood 86, 841 (1995)
15. Cordon-Cardo, C., Amer. J. Pathol. 147, 546 (1995)
16. Vesely, J., Havlicek, L., Strand, M. et al., Eur. J. Biochem. 224, 771 (1994)
17. Grever, M. R., Schepartz, S. A., Chabner, B. A., Semin. Oncol. 19, 622 (1992)
18. Boyd, M. R., Paull, K. D., Drug Dev. Res. 34, 91 (1995)
19. Monks, A., Scudiero, D., Dkehan, P. et al., J. Natl. Cancer Inst. 83, 757 (1991)
20. Freije, J. M., Lawrence, J. A., Hollingshed, M. G. et al., Nat. Med. 3, 395 (1997)
21. Arion, D., Meijer, L., Brizuela, L. et al., Cell 55, 371 (1988)
22. Meijer, L., Arion, D., Golsteyn, R. et al., EMBO J. 8, 2275 (1989)
23. Baratte, B., Meijer, L., Galaktionov, K. et al., Anticancer Res. 12, 873 (1992)
24. Koufaki, M., Polychroniou, V., Caolgeropoulou, T. et al., J. Med. Chem. 39, 2609 (1996)