Diagnosing cervical biopsies in adolescents: The use of p16 immunohistochemistry to improve reliability and reproducibility

Journal of Lower Genital Tract Disease

Volumn 11, Issue 3, 2007, Pages 141-146

  Sayed, Kadria ^a   Korourian, Soheila ^a   Ellison, Dale A ^a   Kozlowski, Karen ^a   Talley, Lori ^a   Horn, Hazel V ^a   Simpson, Pippa ^a   Parham, David M ^a  

^a ARKANSAS CHILDREN S HOSPITAL   (United States)

Author keywords

Adolescent; Cervical biopsy; Cervical intraepithelial neoplasia; HPV; P16

Indexed keywords

MONOCLONAL ANTIBODY;

ADOLESCENT; ADOLESCENT HEALTH; ADULT; ARTICLE; CANCER CYTODIAGNOSIS; CANCER DIAGNOSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPPA STATISTICS; MAJOR CLINICAL STUDY; PATHOLOGY; RELIABILITY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; UTERINE CERVIX BIOPSY; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX CYTOLOGY;

ADOLESCENT; ADULT; BIOPSY; CERVICAL INTRAEPITHELIAL NEOPLASIA; CYCLIN-DEPENDENT KINASE INHIBITOR P16; ELECTROCOAGULATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; OBSERVER VARIATION; SENSITIVITY AND SPECIFICITY; STAINING AND LABELING; UTERINE CERVICAL NEOPLASMS;

EID: 34347366340     PISSN: 10892591     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.lgt.0000265777.36797.e7     Document Type: Article

References (29)

1. Brown DR, Shew ML, Qadadri B, Neptune N, Vargas M, Tu W, et al. A longitudinal study of genital human papillomavirus infection in a cohort of closely followed adolescent women. J Infect Dis 2005;191:182-92.
2. Ley C, Bauer HM, Reingold A, Schiffman MH, Chambers JC, Tashiro CJ, et al. Determinants of genital human papillomavirus infection in young women. J Natl Cancer Inst 1991;83:997-1003.
3. Moscicki AB, Palefsky J, Gonzales J, Schoolnik GK. Human papillomavirus infection in sexually active adolescent females: prevalence and risk factors. Pediatr Res 1990;28:507-13.
4. Rosenfeld WD, Vermund SH, Wentz SJ, Burk RD. High prevalence rate of human papillomavirus infection and association with abnormal Papanicolaou smears in sexually active adolescents. Am J Dis Child 1989;143:1443-7.
5. Morice P, Castaigne D, Pautier P, Rey A, Haie-Meder C, Leblanc M, et al. Interest of pelvic and paraaortic lymphadenectomy in patients with stage IB and II cervical carcinoma. Gynecol Oncol 1999;73:106-10.
6. Stanhope CR, Smith JP, Wharton JT, Rutledge FN, Fletcher GH, Gallager HS. Carcinoma of the cervix: the effect of age on survival. Gynecol Oncol 1980;10:188-93.
7. Hu L, Guo M, He Z, Thornton J, McDaniel LS, Hughson MD. Human papillomavirus genotyping and p16INK4a expression in cervical intraepithelial neoplasia of adolescents. Mod Pathol 2005;18:267-73.
8. de Vet HC, Knipschild PG, Schouten HJ, Koudstaal J, Kwee WS, Willebrand D, et al. Interobserver variation in histopathological grading of cervical dysplasia. J Clin Epidemiol 1990;43:1395-8.
9. de Vet HC, Knipschild PG, Schouten HJ, Koudstaal J, Kwee WS, Willebrand D, et al. Sources of interobserver variation in histopathological grading of cervical dysplasia. J Clin Epidemiol 1992;45:785-90.
10. McCluggage WG, Bharucha H, Caughley LM, Date A, Hamilton PW, Thornton CM, et al. Interobserver variation in the reporting of cervical colposcopic biopsy specimens: comparison of grading systems. J Clin Pathol 1996;49:833-5.
11. Woodhouse SL, Stastny JF, Styer PE, Kennedy M, Praestgaard AH, Davey DD. Interobserver variability in subclassification of squamous intraepithelial lesions: results of the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytology. Arch Pathol Lab Med 1999;123:1079-84.
12. Wells M, Nesland JM, Ostor AG, Goodman AK, Crum CP, Sankaranarayanan R, et al. Tumors of the uterine cervix. In: Tavassoli FA, Devilee P, eds. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. World Health Organization Classification of Tumours. Lyon, France: IARC Press; 2003:269-71.
13. Kalof AN, Evans MF, Simmons-Arnold L, Beatty BG, Cooper K. p16INK4A immunoexpression and HPV in situ hybridization signal patterns: potential markers of high-grade cervical intraepithelial neoplasia. Am J Surg Pathol 2005;29:674-9.
14. Edelman M, Fox AS, Alderman EM, Neal W, Shapiro A, Silver EJ, et al. Cervical Papanicolaou smear abnormalities in inner city Bronx adolescents: prevalence, progression, and immune modifiers. Cancer 1999;87:184-9.
15. Moscicki AB. Human papillomavirus infection in adolescents. Pediatr Clin North Am 1999;46:783-807.
16. Sadeghi SB, Hsieh EW, Gunn SW. Prevalence of cervical intraepithelial neoplasia in sexually active teenagers and young adults. Results of data analysis of mass Papanicolaou screening of 796,337 women in the United States in 1981. Am J Obstet Gynecol 1984;148:726-9.
17. Sadeghi SB, Sadeghi A, Robboy SJ. Prevalence of dysplasia and cancer of the cervix in a nationwide, planned parenthood population. Cancer 1988;61:2359-61.
18. Saslow D, Runowicz CD, Solomon D, Moscicki AB, Smith RA, Eyre HJ, et al. American Cancer Society guideline for the early detection of cervical neoplasia and cancer. CA Cancer J Clin 2002;52:342-62.
19. Stoler MH, Schiffman M. Interobserver reproducibility of cervical cytologic and histologic interpretations: realistic estimates from the ASCUS-LSIL Triage Study. JAMA 2001;285:1500-5.
20. Keating JT, Cviko A, Riethdorf S, Riethdorf L, Quade BJ, Sun D, et al. Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papillomavirus-related cervical neoplasia. Am J Surg Pathol 2001;25:884-91.
21. Klaes R, Friedrich T, Spitkovsky D, Ridder R, Rudy W, Petry U, et al. Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer 2001;92:276-84.
22. Klaes R, Benner A, Friedrich T, Ridder R, Herrington S, Jenkins D, et al. p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol 2002;26:1389-99.
23. Murphy N, Ring M, Killalea AG, Uhlmann V, O'Donovan M, Mulcahy F, et al. p16INK4A as a marker for cervical dyskaryosis: CIN and cGIN in cervical biopsies and ThinPrep smears. J Clin Pathol 2003;56:56-63.
24. Negri G, Egarter-Vigl E, Kasal A, Romano F, Haitel A, Mian C. p16INK4a is a useful marker for the diagnosis of adenocarcinoma of the cervix uteri and its precursors: an immunohistochemical study with immunocytochemical correlations. Am J Surg Pathol 2003;27:187-93.
25. Sano T, Masuda N, Oyama T, Nakajima T. Overexpression of p16 and p14ARF is associated with human papillomavirus infection in cervical squamous cell carcinoma and dysplasia. Pathol Int 2002;52:375-83.
26. van de PG, Holm R, Lie AK, Trope CG, Kristensen GB. Expression of p27, p21, and p16 protein in early squamous cervical cancer and its relation to prognosis. Gynecol Oncol 2003;89:140-7.
27. Aoyama C, Liu P, Ostrzega N, Holschneider CH. Histologic and immunohistochemical characteristics of neoplastic and nonneoplastic subgroups of atypical squamous lesions of the uterine cervix. Am J Clin Pathol 2005;123:699-706.
28. Riethdorf L, Riethdorf S, Lee KR, Cviko A, Loning T, Crum CP. Human papillomaviruses, expression of p16, and early endocervical glandular neoplasia. Hum Pathol 2002;33:899-904.
29. Yoshida T, Fukuda T, Sano T, Kanuma T, Owada N, Nakajima T. Usefulness of liquid-based cytology specimens for the immunocytochemical study of p16 expression and human papillomavirus testing: a comparative study using simultaneously sampled histology materials. Cancer 2004;102:100-8.