Occult HBV infection may represent a major risk factor of non-response to antiviral therapy of chronic hepatitis C

Journal of Medical Virology

Volumn 79, Issue 8, 2007, Pages 1075-1081

  Mrani, S ^a   Chemin, I ^a   Menouar, K ^a   Guillaud, O ^a   Pradat, P ^b   Borghi, G ^b   Trabaud, M A ^c   Chevallier, P ^c   Chevallier, M ^d   Zoulim, F ^a,b   Trepo C ^a,b  

^a INSERM   (France)

^b HÔTEL DIEU   (France)

^c Laboratoire de Virologie Est   (France)

^d LMM Laboratoire Marcel Merieux   (France)

Author keywords

Antiviral therapy; Chronic hepatitis C; HBsAg; HBV DNA; Liver lesions; Occult HBV infection

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; PRIMER DNA; RECOMBINANT ALPHA2A INTERFERON; RECOMBINANT ALPHA2B INTERFERON; RIBAVIRIN; VIRUS DNA;

ADULT; ARTICLE; CHRONIC HEPATITIS; COHORT ANALYSIS; DISEASE ACTIVITY; DISEASE SEVERITY; DRUG TREATMENT FAILURE; FEMALE; FRANCE; GENOTYPE; HEPATITIS B; HEPATITIS C; HISTOPATHOLOGY; HUMAN; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PREVALENCE; REAL TIME POLYMERASE CHAIN REACTION; VIREMIA; VIRUS LOAD;

ADULT; AGED; ANTIVIRAL AGENTS; DRUG THERAPY, COMBINATION; FEMALE; HEPATITIS B; HEPATITIS C, CHRONIC; HUMANS; INTERFERON ALFA-2A; INTERFERON ALFA-2B; MALE; MIDDLE AGED; RIBAVIRIN; RISK FACTORS; TREATMENT FAILURE; VIRAL LOAD;

HEPATITIS B VIRUS; HEPATITIS C VIRUS;

EID: 34347353109     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.20943     Document Type: Article

References (43)

1. Bedossa P, Poynard T. 1996. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology 24:289-293.
2. Brechot C. 2004. Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: Old and new paradigms. Gastroenterology 127: S56-61.
3. Brechot C, Degos F, Lugassy C, Thiers V, Zafrani S, Franco D, Bismuth /SNM> H, Trepo C, Benhamou JP, Wands J, et al. 1985. Hepatitis B virus DNA in patients with chronic liver disease and negative tests for hepatitis B surface antigen. N Engl J Med 312: 270-276.
4. Brechot C, Minami M, De Mitri S, Paterlini P. 1995. Hepatitis B and C viruses in hepatitis B surface antigen negative hepatocellular carcinoma patients. Princess Takamatsu Symp 25:199-209.
5. Brechot C, Thiers V, Kremsdorf D, Nalpas B, Pol S, Paterlini-Brechot P. 2001. Persistent hepatitis B virus infection in subjects without hepatitis B surface antigen: Clinically significant or purely "occult"? Hepatology 34:194-203.
6. Cacciola I, Pollicino T, Squadrito G, Cerenzia G, Orlando ME, Raimondo G. 1999. Occult hepatitis B virus infection in patients with chronic hepatitis C liver disease. N Engl J Med 341:22-26.
7. Carman WF, Van Deursen FJ, Mimms LT, Hardie D, Coppola R, Decker R, Sanders R. 1997. The prevalence of surface antigen variants of hepatitis B virus in Papua New Guinea, South Africa, and Sardinia. Hepatology 26:1658-1666.
8. Chazouilleres O, Mamish D, Kim M, Carey K, Ferrell L, Roberts JP, Ascher NL, Wright TL. 1994. "Occult" hepatitis B virus as source of infection in liver transplant recipients. Lancet 343:142-146.
9. Chemin I, Zoulim F, Merle P, Arkhis A, Chevallier M, Kay A, Cova L, Chevallier P, Mandrand B, Trepo C. 2001. High incidence of hepatitis B infections among chronic hepatitis cases of unknown aetiology. J Hepatol 34:447-454.
10. Chen DS, Kuo GC, Sung JL, Lai MY, Sheu JC, Chen PJ, Yang PM, Hsu HM, Chang MH, Chen CJ, et al. 1990. Hepatitis C virus infection in an area hyperendemic for hepatitis B and chronic liver disease: The Taiwan experience. J Infect Dis 162:817-822.
11. Chen SY, Kao CF, Chen CM, Shih CM, Hsu MJ, Chao CH, Wang SH, You LR, Lee YH. 2003. Mechanisms for inhibition of hepatitis B virus gene expression and replication by hepatitis C virus core protein. J Biol Chem 278:591-607.
12. De Maria N, Colantoni A, Friedlander L, Leandro G, Idilman R, Harig J, Van Thiel DH. 2000. The impact of previous HBV infection on the course of chronic hepatitis C. Am J Gastroenterol 95:3529-3536.
13. Fabris P, Brown D, Tositti G, Bozzola L, Giordani MT, Bevilacqua P, de Lalla F, Webster GJ, Dusheiko G. 2004. Occult hepatitis B virus infection does not affect liver histology or response to therapy with interferon alpha and ribavirin in intravenous drug users with chronic hepatitis C. J Clin Virol 29:160-166.
14. Fukuda R, Ishimura N, Niigaki M, Hamamoto S, Satoh S, Tanaka S, Kushiyama Y, Uchida Y, Ihihara S, Akagi S, Watanabe M, Kinoshita Y. 1999. Serologically silent hepatitis B virus coinfection in patients with hepatitis C virus-associated chronic liver disease: Clinical and virological significance. J Med Virol 58:201-207.
15. Fukuda R, Ishimura N, Hamamoto S, Moritani M, Uchida Y, Ishihara S, Akagi S, Watanabe M, Kinoshita Y. 2001. Co-infection by serologically-silent hepatitis B virus may contribute to poor interferon response in patients with chronic hepatitis C by down-regulation of type-I interferon receptor gene expression in the liver. J Med Virol 63:220-227.
16. Georgiadou SP, Zachou K, Rigopoulou E, Liaskos C, Mina P, Gerovasilis F, Makri E, Dalekos GN. 2004. Occult hepatitis B virus infection in Greek patients with chronic hepatitis C and in patients with diverse nonviral hepatic diseases. J Viral Hepat 11:358-365.
17. Giannini E, Ceppa P, Botta F, Fasoli A, Romagnoli P, Ansaldi F, Durando P, Risso D, Lantieri PB, Icardi GC, Testa R. 2003. Previous hepatitis B virus infection is associated with worse disease stage and occult hepatitis B virus infection has low prevalence and pathogenicity in hepatitis C virus-positive patients. Liver Int 23:12-18.
18. Jilg W, Sieger E, Zachoval R, Schatzl H. 1995. Individuals with antibodies against hepatitis B core antigen as the only serological marker for hepatitis B infection: High percentage of carriers of hepatitis B and C virus. J Hepatol 23:14-20.
19. Kao JH, Chen PJ, Lai MY, Chen DS. 2002. Occult hepatitis B virus infection and clinical outcomes of patients with chronic hepatitis C. J Clin Microbiol 40:4068-4071.
20. Kazemi-Shirazi L, Petermann D, Muller C. 2000. Hepatitis B virus DNA in sera and liver tissue of HBsAg negative patients with chronic hepatitis C. J Hepatol 33:785-790.
21. Koike K. 1999. Co-infection of HBV with HCV and a possible role of HBV DNA in hepatocarcinogenesis. Nippon Rinsho 57:213-219.
22. Koike K, Kobayashi M, Gondo M, Hayashi I, Osuga T, Takada S. 1998. Hepatitis B virus DNA is frequently found in liver biopsy samples from hepatitis C virus-infected chronic hepatitis patients. J Med Virol 54:249-255.
23. Lee DS, Huh K, Lee EH, Lee DH, Hong KS, Sung YC. 1997. HCV and HBV coexist in HBsAg-negative patients with HCV viraemia: Possibility of coinfection in these patients must be considered in HBV-high endemic area. J Gastroenterol Hepatol 12:855-861.
24. Liaw YF, Chien RN, Lin SM, Yeh CT, Tsai SL, Sheen IS, Chu CM. 1997. Response of patients with dual hepatitis B virus and C virus infection to interferon therapy. J Interferon Cytokine Res 17:449-452.
25. Nirei K, Kaneko M, Moriyama M, Arakawa Y. 2000. The clinical features of chronic hepatitis C are not affected by the coexistence of hepatitis B virus DNA in patients negative for hepatitis B surface antigen. Intervirology 43:95-101.
26. Paterlini P, Poussin K, Kew M, Franco D, Brechot C. 1995. Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma. Hepatology 21:313-321.
27. Pontisso P, Ruvoletto MG, Fattovich G, Chemello L, Gallorini A, Ruol A, Alberti A. 1993. Clinical and virological profiles in patients with multiple hepatitis virus infections. Gastroenterology 105:1529-1533.
28. Rozario R, Ramakrishna B. 2003. Histopathological study of chronic hepatitis B and C: A comparison of two scoring systems. J Hepatol 38:223-229.
29. Sagnelli E, Coppola N, Scolastico C, Mogavero AR, Filippini P, Piccinino F. 2001. HCV genotype and "silent" HBV coinfection: Two main risk factors for a more severe liver disease. J Med Virol 64:350-355.
30. Schuttler CG, Fiedler N, Schmidt K, Repp R, Gerlich WH, Schaefer S. 2002. Suppression of hepatitis B virus enhancer 1 and 2 by hepatitis C virus core protein. J Hepatol 37:855-862.
31. Sheu JC, Huang GT, Shih LN, Lee WC, Chou HC, Wang JT, Lee PH, Lai MY, Wang CY, Yang PM, et al. 1992. Hepatitis C and B viruses in hepatitis B surface antigen-negative hepatocellular carcinoma. Gastroenterology 103:1322-1327.
32. Shih CM, Lo SJ, Miyamura T, Chen SY, Lee YH. 1993. Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells. J Virol 67:5823-5832.
33. Shih CM, Chen CM, Chen SY, Lee YH. 1995. Modulation of the trans-suppression activity of hepatitis C virus core protein by phosphorylation. J Virol 69:1160-1171.
34. Simmonds P. 1995. Variability of hepatitis C virus. Hepatology 21:570-583.
35. Squadrito G, Orlando ME, Pollicino T, Raffa G, Restuccia T, Cacciola I, Di Marco V, Picciotto A, Colucci G, Craxi A, Raimondo G. 2002. Virological profiles in patients with chronic hepatitis C and overt or occult HBV infection. Am J Gastroenterol 97:1518-1523.
36. Tamori A, Nishiguchi S, Kubo S, Enomoto M, Koh N, Takeda T, Shiomi S, Hirohashi K, Kinoshita H, Otani S. 2003. Sequencing of human-viral DNA junctions in hepatocellular carcinoma from patients with HCV and occult HBV infection. J Med Virol 69:475-481.
37. Thiers V, Nakajima E, Kremsdorf D, Mack D, Schellekens H, Driss F, Goudeau A, Wands J, Sninsky J, Tiollais P, et al. 1988. Transmission of hepatitis B from hepatitis-B-seronegative subjects. Lancet 2:1273-1276.
38. Uchida T, Kaneita Y, Gotoh K, Kanagawa H, Kouyama H, Kawanishi T, Mima S. 1997. Hepatitis C virus is frequently coinfected with serum marker-negative hepatitis B virus: Probable replication promotion of the former by the latter as demonstrated by in vitro cotransfection. J Med Virol 52:399-405.
39. Villa E, Grottola A, Buttafoco P, Trande P, Merighi A, Fratti N, Seium Y, Cioni G, Manenti F. 1995. Evidence for hepatitis B virus infection in patients with chronic hepatitis C with and without serological markers of hepatitis B. Dig Dis Sci 40:8-13.
40. Yamamoto K, Horikita M, Tsuda F, Itoh K, Akahane Y, Yotsumoto S, Okamoto H, Miyakawa Y, Mayumi M. 1994. Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen. J Virol 68:2671-2676.
41. Zhang YY, Hansson BG, Kuo LS, Widell A, Nordenfelt E. 1993. Hepatitis B virus DNA in serum and liver is commonly found in Chinese patients with chronic liver disease despite the presence of antibodies to HBsAg. Hepatology 17:538-544.
42. Zignego AL, Foschi M, Laffi G, Monti M, Careccia G, Romanelli RG, De Majo E, Mazzanti R, Buzzelli G, La Villa G, et al. 1994. "Inapparent" hepatitis B virus infection and hepatitis C virus replication in alcoholic subjects with and without liver disease. Hepatology 19:577-582.
43. Zignego AL, Fontana R, Puliti S, Barbagli S, Monti M, Careccia G, Giannelli F, Giannini C, Buzzelli G, Brunetto MR, Bonino F, Gentilini P. 1997. Relevance of inapparent coinfection by hepatitis B virus in alpha interferon-treated patients with hepatitis C virus chronic hepatitis. J Med Virol 51:313-318.