c-Abl tyrosine kinase activates p21 transcription via interaction with p53

Journal of Biochemistry

Volumn 141, Issue 5, 2007, Pages 621-626

  Jing, Yuqi ^a   Wang, Min ^a   Tang, Wen ^a   Qi, Tianyang ^a   Gu, Chunsheng ^a   Hao, Shui ^a   Zeng, Xianlu ^a  

^a NORTHEAST NORMAL UNIVERSITY   (China)

Author keywords

c abl tyrosine kinase; Gene transcription; p21; p53

Indexed keywords

ABELSON KINASE; P21 ACTIVATED KINASE; PROTEIN P53;

ARTICLE; BINDING AFFINITY; CELL DIFFERENTIATION; HUMAN; HUMAN CELL; PROTEIN FUNCTION; PROTEIN INTERACTION; STRESS; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; HUMANS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-ABL; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34347339663     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvm068     Document Type: Article

References (26)

1. Shaul, Y. (2000) c-Abl: activation and nuclear targets. Cell Death Differ. 7, 10-16
2. Van Etten, R.A. (1999) Cycling, stressed-out and nervous: cellular functions of c-Abl. Trends Cell Biol. 9, 179-186
3. Taagepera, S., McDonald, D., Loeb, J.E., Whitaker, L.L., McElroy, A.K., Wang, J.Y.J., and Hope, T.J. (1998) Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase. Proc. Natl. Acad. Sci. USA 95, 7457-7462
4. Hardin, J.D., Boast, S., Schwartzberg, P.L., Lee, G., Alt, F.W., Stall, A.M., and Goff, S.P. (1996) Abnormal peripheral lymphocyte function in c-abl mutant mice. Cell Immunol. 172, 100-107
5. Li, B., Boast, S., de los Santos, K., Schieren, I., Quiroz, M., Teitelbaum, S.L., Tondravi, M.M., and Goff, S.P. (2000) Mice deficient in Abl are osteoporotic and have defects in osteoblast maturation. Nat. Genet. 24, 304-308
6. Tybulewicz, V.L., Crawford, C.E., Jackson, P.K., Bronson, R.T., and Mulligan, R.C. (1991) Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65, 1153-1163
7. Sawyers, C.L., McLauglin, J., Goga, A., Havlik, M., and Witte, O. (1994) The nuclear tyrosine kinase c-Abl negatively regulates cell growth. Cell 77, 121-131
8. Kharbanda, S., Yuan, Z.M., Weichselbaum, R., and Kufe, D. (1997) Functional role for the c-Abl protein tyrosine kinase in the cellular response to genotoxic stress. Biochim. Biophys. Acta. 1333, 1-7
9. Ba, X., Chen, C., Gao, Y., and Zeng, X. (2005) Signaling function of PSGL-1 in neutrophil: tyrosine-phosphorylation-dependent and c-Abl-involved alteration in the F-actin-Based cytoskeleton. J. Cell Biochem. 94, 365-373
10. Arcinas, M., Sizer, K.C., and Boxer, L.M. (1994) Activation of c-myc expression by c-Abl is independent of both the DNA binding function of c-Abl and the c-myc EP site. J. Biol. Chem. 269, 21919-21924
11. Jing, Y., Song, Z., Wang, M., Tang, W., Hao, S., and Zeng, X. (2005) c-Abl tyrosine kinase regulates c-fos gene expression via phosphorylating RNA polymerase II. Arch. Biochem. Biophy. 437, 199-204
12. Agami, R. and Shaul, Y. (1998) The kinase activity of c-Abl but not v-Abl is potentiated by direct interaction with RFXI, a protein that binds the enhancers of several viruses and cell-cycle regulated genes. Oncogene 16, 1779-1788
13. Yuan, Z.M., Huang, Y., Whang, Y., Sawyers, C., Weichselbaum, R., Kharbanda, S., and Kufe, D. (1996) Role for c-Abl tyrosine kinase in growth arrest response to DNA damage. Nature 382, 272-274
14. Wen, S.T., Jackson, P.K., and Van Etten, R.A. (1996) The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products. EMBO J. 15, 1583-1595
15. Sionov, R.V., Moallem, E., Berger, M., Kazaz, A., Gerlitz, O., Ben-Neriah, Y., Oren, M., and Haupt, Y. (1999) c-Abl neutralizes the inhibitory effect of Mdm2 on p53. J. Biol. Chem. 274, 8371-8374
16. Khanna, S.J., Brown, R., Whetton, A.D., Ball, K.L., and Dive, C. (2001) v-Abl protein-tyrosine kinase up-regulates p21WAF-1 in cell cycle arrested and proliferating myeloid cells. J. Biol. Chem. 276, 11143-11150
17. Huang, Y., Yuan, Z.M., Ishiko, T., Nakada, S., Utsugisawa, T., Kato, T., Kharbanda, S., and Kufe, D.W. (1997) Pro-apoptotic effect of the c-Abl tyrosine kinase in the cellular response to 1-beta-D-arabinofuranosylcytosine. Oncogene 15, 1947-1952
18. Schindler, T., Bornmann, W., Pellicena, P., Miller, W.T., Clarkson, B., and Kuriyan, J. (2000) Structural mechanism for STI-571 inhibition of abelson tyrosine kinase. Science 289, 1938-1942
19. Buchdunger, E., Zimmermann, J., Mett, H., Muller, M., Druker, B.J., and Lydon, N.B. (1996) Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res. 56, 100-104
20. (WAF1/CIP1) gene. Exp. Cell. Res. 246, 280-289
21. Dikstein, R., Heffetz, D., Ben-Neriah, Y., and Shaul, Y. (1992) c-abl has a sequence-specific enhancer binding activity. Cell 69, 751-757
22. Dikstein, R., Agami, R., Heffetz, D., and Shaul, Y. (1996) p140/c-Abl that binds DNA is preferentially phosphorylated at tyrosine residues. Proc. Natl. Acad. Sci. USA 93, 2387-2391
23. Kharbanda, S., Yuan, Z.M., Weichselbaum, R., and Kufe, D. (1998) Determination of cell fate by c-Abl activation in the response to DNA damage. Oncogene 17, 3309-3318
24. Yuan, Z.M., Huang, Y., Fan, M.M., Sawyers, C., Kharbanda, S., and Kufe, D. (1996) Genotoxic drugs induce interaction of the c-Abl tyrosine kinase and the tumor suppressor protein p53. J. Biol. Chem. 271, 26457-26460
25. Goga, A., Liu, X., Hambuch, T.M., Senechal, K., Major, E., Berk, A.J., Witte, O.N., and Sawyers, C.L. (1995) p53 dependent growth suppression by the c-Abl nuclear tyrosine kinase. Oncogene 11, 791-799
26. Nie, Y., Li, H.H., Bula, C.M., and Liu, X. (2000) Stimulation of p53 DNA binding by c-Abl requires the p53 C terminus and tetramerization. Mol. Cell Biol. 20, 741-748