Intrathecal drug delivery strategy is safe and efficacious for localized delivery to the spinal cord

Progress in Brain Research

Volumn 161, Issue , 2007, Pages 385-392

  Shoichet, Molly S ^a,b   Tator, Charles H ^c   Poon, Peter ^a,b   Kang, Catherine ^a,b   Douglas Baumann, M ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

collagen; epidermal growth factor; hyaluronan; hydrogels; localized drug delivery; methyl cellulose; spinal cord injury

Indexed keywords

COLLAGEN GEL; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 2; GAMMA UROGASTRONE; HYALURONIC ACID; METHYLCELLULOSE;

BIOCOMPATIBILITY; COMPRESSION FRACTURE; DRUG DELIVERY SYSTEM; DRUG SAFETY; HUMAN; METHODOLOGY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SPINAL CORD; TECHNOLOGY;

ANIMALS; DRUG DELIVERY SYSTEMS; GELS; HUMANS; INJECTIONS, SPINAL; NEUROPROTECTIVE AGENTS; SPINAL CORD INJURIES;

EID: 34347335569     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6123(06)61027-3     Document Type: Review

References (34)

1. Balazs E.A. Cosmetic and pharmaceutical applications of polymers. In: Gebelein C.G. (Ed). Medical Applications of Hyaluronan and its Derivatives (1991), Plenum Press, New York 293-310
2. Basso D.M., Beattie M.S., and Bresnahan J.C. Graded histological and locomotor outcomes after spinal cord contusion using the NYU weight-drop device versus transection. Exp. Neurol. 139 (1996) 244-256
3. Cabrera P.V., Blanco G., Alaniz L., Greczanik S., Garcia M., Alvarez E., and Hajos S.E. CD44 and hyaluronic acid regulate in vivo iNOS expression and metalloproteinase activity in murine air-pouch inflammation. Inflamm. Res. 53 (2004) 556-566
4. Dergham P., Ellezam B., Essagian C., Avedissian H., Lubell W.D., and McKerracher L. Rho signaling pathway targeted to promote spinal cord repair. J. Neurosci. 22 (2002) 6570-6577
5. Dougados M. Sodium hyaluronate therapy in osteoarthritis: arguments for a potential beneficial structural effect. Semin. Arthritis Rheum. 30 (2000) 19-25
6. Gorio A., Gokmen N., Erbayraktar S., Yilmaz O., Madaschi L., Cichetti C., Di Giulio A.M., Vardar E., Cerami A., and Brines M. Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma. Proc. Natl. Acad. Sci. USA 99 (2002) 9450-9455
7. Gupta D., Tator C.H., and Shoichet M.S. Fast-gelling injectable blend of hyaluronan and methylcellulose for intrathecal, localized delivery to the injured spinal cord. Biomaterials 27 (2006) 2370-2379
8. Hains B.C., Saab C.Y., Lo A.C., and Waxman S.G. Sodium channel blockade with phenytoin protects spinal cord axons, enhances axonal conduction, and improves functional motor recovery after contusion SCI. Exp. Neurol. 188 (2004) 365-377
9. Hurlbert R.J. The role of steroids in acute spinal cord injury: an evidence-based analysis. Spine 26 (2001) S39-S46
10. Jimenez Hamann M.C., Tator C.H., and Shoichet M.S. Injectable intrathecal delivery system for localized administration of EGF and FGF-2 to the injured rat spinal cord. Exp. Neurol. 194 (2005) 106-119
11. Jimenez Hamann M.C., Tsai E.C., Tator C.H., and Shoichet M.S. Novel intrathecal delivery system for treatment of spinal cord injury. Exp. Neurol. 182 (2003) 300-309
12. Jones L.L., and Tuszynski M.H. Chronic intrathecal infusions after spinal cord injury cause scarring and compression. Microsc. Res. Tech. 54 (2001) 317-324
13. Knoller N., Auerbach G., Fulga V., Zelig G., Attias J., Bakimer R., Marder J.B., Yoles E., Belkin M., Schwartz M., and Hadani M. Clinical experience using incubated autologous macrophages as a treatment for complete spinal cord injury: phase I study results. J. Neurosurg. Spine 3 (2005) 173-181
14. Kojima A., and Tator C.H. Epidermal growth factor and fibroblast growth factor 2 cause proliferation of ependymal precursor cells in the adult rat spinal cord in vivo. J. Neuropathol. Exp. Neurol. 59 (2000) 687-697
15. Li L., Thangamathesvaran P.M., Yue C.Y., Tam K.C., Hu X., and Lam Y.C. Gel network structure of methylcellulose in water. Langmuir 17 (2001) 8062-8068
16. Martens D.J., Seaberg R.M., and van der Kooy D. In vivo infusions of exogenous growth factors into the fourth ventricle of the adult mouse brain increase the proliferation of neural progenitors around the fourth ventricle and the central canal of the spinal cord. Eur. J. Neurosci. 16 (2002) 1045-1057
17. McKerracher L., and Higuchi H. Targeting Rho to stimulate repair after spinal cord injury. J. Neurotrauma 23 (2006) 309-317
18. Metz G.A., Merkler D., Dietz V., Schwab M.E., and Fouad K. Efficient testing of motor function in spinal cord injured rats. Brain Res. 883 (2000) 165-177
19. Pearse D.D., Pereira F.C., Marcillo A.E., Bates M.L., Berrocal Y.A., Filbin M.T., and Bunge M.B. cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury. Nat. Med. 10 (2004) 610-616
20. Rabchevsky A.G., Fugaccia I., Fletcher-Turner A., Blades D.A., Mattson M.P., and Scheff S.W. Basic fibroblast growth factor (bFGF) enhances tissue sparing and functional recovery following moderate spinal cord injury. J. Neurotrauma 16 (1999) 817-830
21. Ramer L.M., Ramer M.S., and Steeves J.D. Setting the stage for functional repair of spinal cord injuries: a cast of thousands. Spinal Cord 43 (2005) 134-161
22. Rapalino O., Lazarov-Spiegler O., Agranov E., Velan G.J., Yoles E., Fraidakis M., Solomon A., Gepstein R., Katz A., Belkin M., Hadani M., and Schwartz M. Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats. Nat. Med. 4 (1998) 814-821
23. Rieselbach R.E., Di Chiro G., Freireich E.J., and Rall D.P. Subarachnoid distribution of drugs after lumbar injection. N. Engl. J. Med. 267 (1962) 1273-1278
24. Rivlin A.S., and Tator C.H. Objective clinical assessment of motor function after experimental spinal cord injury in the rat. J. Neurosurg. 47 (1977) 577-581
25. Rivlin A.S., and Tator C.H. Effect of duration of acute spinal cord compression in a new acute cord injury model in the rat. Surg. Neurol. 10 (1978) 38-43
26. Roth A., Mollenhauer J., Wagner A., Fuhrmann R., Straub A., Venbrocks R.A., Petrow P., Brauer R., Schubert H., Ozegowski J., Peschel G., Muller P.J., and Kinne R.W. Intra-articular injections of high-molecular-weight hyaluronic acid have biphasic effects on joint inflammation and destruction in rat antigen-induced arthritis. Arthritis Res. Ther. 7 (2005) R677-R686
27. Schwartz, M. (2003) Macrophages and microglia in central nervous system injury: are they helpful or harmful? J Cereb Blood Flow Metab., 23, 385-394.
28. Sheehan K.M., DeLott L.B., Day S.M., and DeHeer D.H. Hyalgan has a dose-dependent differential effect on macrophage proliferation and cell death. J. Orthop. Res. 21 (2003) 744-751
29. Terada H., Kazui T., Takinami M., Yamashita K., Washiyama N., and Muhammad B.A. J. Thorac. Cardiovasc. Surg. 122 (2001) 979-985
30. Tsai E.C., Dalton P.D., Shoichet M.S., and Tator C.H. Synthetic hydrogel guidance channels facilitate regeneration of adult rat brainstem motor axons after complete spinal cord transection. J. Neurotrauma 21 (2004) 789-804
31. Vercruysse K.P., and Prestwich G.D. Hyaluronate derivatives in drug delivery. Crit. Rev. Ther. Drug Carrier Syst. 15 (1998) 513-555
32. Weiss, C. (2000). New frontiers in medical sciences: redefining Hyaluronan. In: Weigel, G. A. a. P. H. (Eds.), Why Viscoelasticity is Important for the Medical Uses of Hyaluronan and Hylans. Excerpta Medica, pp. 89-103.
33. Xu Y., Wang C., Tam K.C., and Li L. Salt-assisted and salt-suppressed sol-gel transitions of methylcellulose in water. Langmuir 20 (2004) 646-652
34. Yaksh T.L., Horais K.A., Tozier N., Rathbun M., Richter P., Rossi S., Grafe M., Tong C., Meschter C., Cline J.M., and Eisenach J. Toxicol Sci. 80 (2004) 322-334