Antitumor effect of combination therapy of proflamin with cryosurgery of Meth-A fibrosarcoma in BALB/c mice

International Journal of Medicinal Mushrooms

Volumn 7, Issue 4, 2005, Pages 539-545

  Maruyama, Hirofumi ^a   Ikekawa, Tetsuro ^a  

^a Japanese Association for Integrative Medicine   (Japan)

Author keywords

Antitumor immunity; Antitumor polysaccharides; Combination therapy; Cryosurgery; Flammulina velutipes; Glycoprotein; Proflamin

Indexed keywords

BIOLOGICAL RESPONSE MODIFIER; POLYSACCHARIDE; PROFLAMIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BASIDIOMYCETES; CANCER GRAFT; CANCER INHIBITION; CONTROLLED STUDY; CRYOSURGERY; DELAYED HYPERSENSITIVITY; EDIBLE MUSHROOM; FEMALE; FIBROSARCOMA; FLAMMULINA VELUTIPES; FUNGUS CULTURE; IMMUNOCOMPETENCE; IMMUNOMODULATION; JAPAN; MOUSE; MYCELIUM; NONHUMAN; SPLEEN CELL; STATISTICAL ANALYSIS; TUMOR IMMUNITY;

ANIMALIA; BASIDIOMYCOTA; FLAMMULINA VELUTIPES; FUNGI;

EID: 33645504600     PISSN: 15219437     EISSN: None     Source Type: Journal    
DOI: 10.1615/IntJMedMushr.v7.i4.30     Document Type: Article

References (17)

1. Ablin R. J., Soanes W. A., Gonder M. J. 1971. Prospects for cryo-immunotherapy in cases of metastasizing carcinoma of the prostate. Cryobiology, 8, 271-279.
2. Demetrius H. B., Robert P. F., Joanne C. M., Robert M. B. 1974. Lymphocyte mediated cytotoxicity after cryosurgery of a murine sarcoma. J Surg Res, 17, 404-406.
3. Ikekawa T., Maruyama H., Miyano T., Okura A., Sawasaki Y., Naito K., Kawamura K., Shiratori K. 1985. Proflamin, a new antitumor agent: preparation, physicochemical properties and antitumor activity. Jpn J Cancer Res (Gann), 76, 142-148.
4. Ikekawa T., Uehara N., Maeda Y., Nakanishi M., Fukuoka F. 1969. Antitumor activity of aqueous extracts of edible mushrooms. Cancer Res, 29, 734-735.
5. Ikekawa T., Yosioka Y., Emori M., Sano T., Fukuoka F. 1973. Studies on antitumor activity of polysaccharides from Flammulina velutipes (Curt. ex Fr.) Sing. Cancer Chemotherapy Reports Part 1, 57, 85-86.
6. Miya K., Sari S., Morita T., Nina H., Takao H., Kida H., Sakata K. 1986. Immunological response of regional lymph nodes after tumor cryosurgery: experimental study in rats. Cryobiology, 23, 290-295.
7. Myers R. S., Hammond W. G., Ketchan A. S. 1969. Tumor-specific transplantation immunity after cryosurgery. J Surg Oncol, 1, 241-245.
8. Neel H. B., Ketchan A. S., Hammond W. G. 1973. Experimental evaluation of in situ oncocide for primary tumor therapy: comparison of tumor specific immunity after complete excision, cryonecrosis and ligation. Laryngoscope, 83, 376-387.
9. Niwa H., Saji S., Ooiwa T., Kunii Y., Morita T., Miya K., Sakata K. 1987a. Studies on immunosuppression of the serum factor after tumor cryosurgery. I. Effects on PHA-induced lymphoblastogenesis. J Low Temp Med, 13, 59-66.
10. Niwa H., Saji S., Kesikawa I., Ohnishi A., Morita T., Tachibana S., Miya K., Sakata K. 1987b. Studies on immunosuppression of the serum factor after tumor cryosurgery. II. Effects on Con A-induced lymphoblastogenesis. J Low Temp Med, 13, 67-73.
11. Ohkuma T., Tanaka S., Ikekawa T. 1983. Augmentation of host's immunity by combined cryo-destruction of Sarcoma 180 and administration of protein-bound polysaccharide, EA6, isolated from Flammulina velutipes (Curt. ex Fr.) Sing. in ICR mice. J Pharm Dyn, 6, 88-95.
12. Shibata T., Suzuki K., Yamashita T. 2002. Immunological responses in WKA rats following cryosurgery of 3-methylcholanthrene induced fibrosarcoma (KMT-17) and review of cryo-immunology. Low Temp Med, 28, 13-17.
13. Shibata T., Suzuki K., Yamashita T., Takeichi N., Mark M., Hosokawa M., Kobayashi H., Arisue M. 1998. Immunological analysis of enhanced spontaneous metastasis in WKA rats following cryosurgery. Anticancer Res, 18, 2483-2486.
14. Tanaka S. 1982. Immunological aspects of cryosurgery in general surgery. Cryobiology, 19, 257-272.
15. Winn H. J. 1961. Immune mechanisms in homotransplantation. II. Quantitative assay of the immunologie activity of lymphoid cells stimulated by tumor homografts. J Immunol, 86, 228-235.
16. Yamashita T., Hayakawa K., Hosokawa M., Kodama T., Inoue N., Tomiya K., Kobayashi M. 1982. Enhanced tumor metastases in rats following cryosurgery of primary tumor. Jpn J Cancer Res (Gann), 73, 222-228.
17. Yosioka Y., Sano T., Ikekawa T. 1973. Studies on antitumor polysaccharides of Flammulina velutipes (Curt. ex Fr.) Sing. I. Chem Pharm Bull, 21, 1772-1776.