Dexmedetomidine reduces seizure threshold during enflurane anaesthesia in cats

British Journal of Anaesthesia

Volumn 82, Issue 6, 1999, Pages 935-937

  Miyazaki, Y ^a   Adachi, T ^a   Kurata, J ^a   Utsumi, J ^a   Shichino, T ^a   Segawa, H ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Anaesthetics volatile, enflurane; Cat; Complications, seizure; Monitoring, electroencephalogram; Sympathetic nervous system, dexmedetomidine

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ANESTHETIC AGENT; CONVULSANT AGENT; DEXMEDETOMIDINE; ENFLURANE; YOHIMBINE;

ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; CAT; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; INHALATIONAL DRUG ADMINISTRATION; MESENCEPHALON RETICULAR FORMATION; NONHUMAN; PRIORITY JOURNAL; SEIZURE THRESHOLD;

EID: 0033054863     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/82.6.935     Document Type: Article

References (6)

1. Mirski MAZ, Rossell LA, McPherson RW, Trystman RJ. Dexmedetomidine decreases seizure threshold in a rat model of experimental generalized epilepsy. Anesthesiology 1994; 8: 1422-8
2. Stevens JE, Oshima E, Mori K. Effects of nitrous oxide on the epileptogenic property of enflurane in cats. Br J Anaesth 1983; 55: 145-54
3. Kurata J, Adachi T, Nakao S, et al. Sevoflurane, enflurane and isoflurane have no persistent postanaesthetic effects on the central nervous system in cats. Br J Anaesth 1996; 76: 721-5
4. Gellman RL, Kallianos JA, McNamala JO. Alpha-2 receptors mediate an endogenous noradrenergic suppression of kindling development. J Pharmacol Exp Ther 1987; 181: 339-45
5. 2-antagonist idazoxan promotes seizures - a microinfusion study in amygdala-kindled kittens. Brain Res 1994; 648: 352-6
6. Yan Q-S, Jobe PC, Dailey JW. Noradrenergic mechanisms for the anticonvulsant effects of desipiramine and yohimbine in genetically epilepsy-prone rats: studies with microdialysis. Brain Res 1993; 610: 24-31