메뉴 건너뛰기




Volumn 23, Issue 6, 2007, Pages 1463-1472

The cost of treating ribavirin-induced anemia in hepatitis C: The impact of using recombinant human erythropoietin

Author keywords

Cost; Epoetin; Hepatitis C; Ribavirin induced anemia

Indexed keywords

HEMOGLOBIN; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; REBETRON; RECOMBINANT ERYTHROPOIETIN; RIBAVIRIN;

EID: 34347268423     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/030079907X188189     Document Type: Conference Paper
Times cited : (7)

References (42)
  • 1
    • 34347209108 scopus 로고    scopus 로고
    • World Health Organization, Available from URL:, accessed March 12
    • World Health Organization. Fact Sheet Number 164. Available from URL: http://www.who.int/mediacentre/factsheets/fs164/en/print.html [accessed March 12, 2007]
    • (2007) Fact Sheet , Issue.164
  • 2
    • 0036828784 scopus 로고    scopus 로고
    • The burden of hepatitis C in the United States
    • Kim WR. The burden of hepatitis C in the United States. Hepatology 2002;36:S30-S34
    • (2002) Hepatology , vol.36
    • Kim, W.R.1
  • 3
    • 0032547944 scopus 로고    scopus 로고
    • Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C
    • Davis GL, Esteban-Mur R, Rustgi V, et al. Interferon alfa-2b alone or in combination with ribavirin for the treatment of relapse of chronic hepatitis C. New Engl J Med 1998;339:1493-9
    • (1998) New Engl J Med , vol.339 , pp. 1493-1499
    • Davis, G.L.1    Esteban-Mur, R.2    Rustgi, V.3
  • 4
    • 0032547938 scopus 로고    scopus 로고
    • Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C
    • McHutchison JG, Gordon SC, Schiff ER, et al. Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. New Engl J Med 1998;339:1485-92
    • (1998) New Engl J Med , vol.339 , pp. 1485-1492
    • McHutchison, J.G.1    Gordon, S.C.2    Schiff, E.R.3
  • 5
    • 0032585237 scopus 로고    scopus 로고
    • Randomised trial of interferon α-2b plus ribavirin for 48 weeks or for 24 weeks versus interferon α-2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus
    • Poynard T, Marcellin P, Lee SS, et al. Randomised trial of interferon α-2b plus ribavirin for 48 weeks or for 24 weeks versus interferon α-2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. Lancet 1998;352:1426-32
    • (1998) Lancet , vol.352 , pp. 1426-1432
    • Poynard, T.1    Marcellin, P.2    Lee, S.S.3
  • 6
    • 0035934568 scopus 로고    scopus 로고
    • Peginteron-alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomized trial
    • Manns MP, McHutchison JG, Gordon SC, et al. Peginteron-alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomized trial. Lancet 2001;358:958-65
    • (2001) Lancet , vol.358 , pp. 958-965
    • Manns, M.P.1    McHutchison, J.G.2    Gordon, S.C.3
  • 7
    • 0037179698 scopus 로고    scopus 로고
    • Peg interferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
    • Fried MW, Shiffman ML, Reddy R, et al. Peg interferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. New Engl J Med 2002;347:975-82
    • (2002) New Engl J Med , vol.347 , pp. 975-982
    • Fried, M.W.1    Shiffman, M.L.2    Reddy, R.3
  • 8
    • 1542378867 scopus 로고    scopus 로고
    • PEGASYS International Study Group. Peginterferon-α2a and ribavirin combination therapy in chronic hepatitis C
    • Hadziyannis SJ, Settee H, Morgan TR, et al. PEGASYS International Study Group. Peginterferon-α2a and ribavirin combination therapy in chronic hepatitis C. Ann Intern Med 2004;140:346-55
    • (2004) Ann Intern Med , vol.140 , pp. 346-355
    • Hadziyannis, S.J.1    Settee, H.2    Morgan, T.R.3
  • 9
    • 19944428400 scopus 로고    scopus 로고
    • Tokyo-Chiba Hepatitis Research Group. Antiviral therapy for cirrhotic hepatitis C: Association with reduced hepatocellular carcinoma development and improved survival
    • Shiratori Y, Ito Y, Yokosuka O, et al.; Tokyo-Chiba Hepatitis Research Group. Antiviral therapy for cirrhotic hepatitis C: association with reduced hepatocellular carcinoma development and improved survival. Ann Intern Med 2005;142:105-14
    • (2005) Ann Intern Med , vol.142 , pp. 105-114
    • Shiratori, Y.1    Ito, Y.2    Yokosuka, O.3
  • 10
    • 0036788338 scopus 로고    scopus 로고
    • International Hepatitis Interventional Therapy Group. Adherence to combination therapy enhances sustained response in genotype-1 infected patients with chronic hepatitis C
    • McHutchison JG, Manns M, Patel K, et al.; International Hepatitis Interventional Therapy Group. Adherence to combination therapy enhances sustained response in genotype-1 infected patients with chronic hepatitis C. Gastroenterology 2002;123:1061-9
    • (2002) Gastroenterology , vol.123 , pp. 1061-1069
    • McHutchison, J.G.1    Manns, M.2    Patel, K.3
  • 11
    • 33644547946 scopus 로고    scopus 로고
    • Treatment of chronic hepatitis C virus (HCV) genotype 1 with peginterferon alfa-2b (PEGIFN), high weight based dose ribavirin (RVN) and epoetin alfa (EPO) enhances sustained virologic response (SVR)
    • Shiffrnan ML, Price A, Hubbard S, et al. Treatment of chronic hepatitis C virus (HCV) genotype 1 with peginterferon alfa-2b (PEGIFN), high weight based dose ribavirin (RVN) and epoetin alfa (EPO) enhances sustained virologic response (SVR). Hepatology 2005;42(Suppl 1):217A
    • (2005) Hepatology , vol.42 , Issue.SUPPL. 1
    • Shiffrnan, M.L.1    Price, A.2    Hubbard, S.3
  • 12
    • 1842463813 scopus 로고    scopus 로고
    • Changes in haemoglobin during interferon alpha-2b plus ribavirin combination therapy for chronic hepatitis C virus infection
    • Sulkowski MS, Wasserman R, Brooks L, et al. Changes in haemoglobin during interferon alpha-2b plus ribavirin combination therapy for chronic hepatitis C virus infection. J Viral Hepatitis 2004;11:243-50
    • (2004) J Viral Hepatitis , vol.11 , pp. 243-250
    • Sulkowski, M.S.1    Wasserman, R.2    Brooks, L.3
  • 13
    • 0034821017 scopus 로고    scopus 로고
    • A preliminary study of erythropoietin for anemia associated with ribavirin and interferon-α
    • Talal AH, Weisz K, Hau T, et al. A preliminary study of erythropoietin for anemia associated with ribavirin and interferon-α. Am J Gastroenterol 2003;96:2802-3
    • (2003) Am J Gastroenterol , vol.96 , pp. 2802-2803
    • Talal, A.H.1    Weisz, K.2    Hau, T.3
  • 14
    • 18544388832 scopus 로고    scopus 로고
    • Premature discontinuation of interferon plus ribavirin for adverse effects: A multicentre survey in 'real world' patients with chronic hepatitis C
    • Gaeta GB, Precone DF, Felaco FM, et al. Premature discontinuation of interferon plus ribavirin for adverse effects: a multicentre survey in 'real world' patients with chronic hepatitis C. Aliment Pharmacol Ther 2002;16:1633-9
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 1633-1639
    • Gaeta, G.B.1    Precone, D.F.2    Felaco, F.M.3
  • 15
    • 0036307087 scopus 로고    scopus 로고
    • Rapid suppression of hematopoiesis by standard or pegylated interferon-alfa
    • Peck-Radosavljevic M, Wichlas M, Homoncik-Kraml M, et al. Rapid suppression of hematopoiesis by standard or pegylated interferon-alfa. Gastroenterology 2002;123:141-51
    • (2002) Gastroenterology , vol.123 , pp. 141-151
    • Peck-Radosavljevic, M.1    Wichlas, M.2    Homoncik-Kraml, M.3
  • 16
    • 17744389383 scopus 로고    scopus 로고
    • Efficacy and safety of pegylated (40-kd) interferon α-2a compared with interferon α-2a in noncirrhotic patients with chronic hepatitis C
    • Reddy KR, Wright TL, Pockros PJ, et al. Efficacy and safety of pegylated (40-kd) interferon α-2a compared with interferon α-2a in noncirrhotic patients with chronic hepatitis C. Hepatology 2001;33:433-8
    • (2001) Hepatology , vol.33 , pp. 433-438
    • Reddy, K.R.1    Wright, T.L.2    Pockros, P.J.3
  • 17
    • 13944250319 scopus 로고    scopus 로고
    • HCV Natural History Study Group. Erythropoietic response to anemia in chronic hepatitis C patients receiving combination pegylated interferon/ribavirin
    • Balan V, Schwartz D, Wu GY, et al.; HCV Natural History Study Group. Erythropoietic response to anemia in chronic hepatitis C patients receiving combination pegylated interferon/ribavirin. Am J Gastroenterol 2005;100:299-307
    • (2005) Am J Gastroenterol , vol.100 , pp. 299-307
    • Balan, V.1    Schwartz, D.2    Wu, G.Y.3
  • 18
    • 34347209107 scopus 로고    scopus 로고
    • Dieterich D, Weisz K, Goldman D, et al. Interferon (IFN) and ribavirin (RBV) therapy for hepatitis C (HCV) in HIV-co-infected patients. In: Program and abstracts of the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy (San Francisco, CA). Washington (DC): American Society for Microbiology; 1999. p. 415 [abstract]
    • Dieterich D, Weisz K, Goldman D, et al. Interferon (IFN) and ribavirin (RBV) therapy for hepatitis C (HCV) in HIV-co-infected patients. In: Program and abstracts of the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy (San Francisco, CA). Washington (DC): American Society for Microbiology; 1999. p. 415 [abstract]
  • 19
    • 0242437747 scopus 로고    scopus 로고
    • Once-weekly epoetin alfa improves anemia and facilitates maintenance of ribavirin dosing in hepatitis C virus-infected patients receiving ribavirin plus interferon alfa
    • Dieterich DT, Wasserman R, Brau N, et al. Once-weekly epoetin alfa improves anemia and facilitates maintenance of ribavirin dosing in hepatitis C virus-infected patients receiving ribavirin plus interferon alfa. Am J Gastroenterol 2003;98:2491-9
    • (2003) Am J Gastroenterol , vol.98 , pp. 2491-2499
    • Dieterich, D.T.1    Wasserman, R.2    Brau, N.3
  • 20
    • 11144358403 scopus 로고    scopus 로고
    • Proactive Study Group. Epoetin alfa maintains ribavirin dose in HCV-infected patients: A prospective, double-blind, randomized controlled study
    • Afdhal NH, Dieterich DT, Pockros PJ, et al.; Proactive Study Group. Epoetin alfa maintains ribavirin dose in HCV-infected patients: a prospective, double-blind, randomized controlled study. Gastroenterology 2004;126:1302-11
    • (2004) Gastroenterology , vol.126 , pp. 1302-1311
    • Afdhal, N.H.1    Dieterich, D.T.2    Pockros, P.J.3
  • 21
    • 34347248093 scopus 로고    scopus 로고
    • AHFS Drug Information 2005. Bethesda: American Society of Health-System Pharmacists, 2005
    • AHFS Drug Information 2005. Bethesda: American Society of Health-System Pharmacists, 2005
  • 22
    • 4644349357 scopus 로고    scopus 로고
    • Darbepoetin alfa for ribavirin-induced anemia in patients with chronic hepatitis C treated with pegylated interferon and ribavirin: A preliminary analysis [Abstract]
    • Younossi ZM, Ong JP, Collantes R. Darbepoetin alfa for ribavirin-induced anemia in patients with chronic hepatitis C treated with pegylated interferon and ribavirin: a preliminary analysis [Abstract]. Gastroenterology 2004;126(Suppl 1):83A
    • (2004) Gastroenterology , vol.126 , Issue.SUPPL. 1
    • Younossi, Z.M.1    Ong, J.P.2    Collantes, R.3
  • 23
    • 11144328172 scopus 로고    scopus 로고
    • Erythropoietin maintains ribavirin dose and sustained virologic response during HCV treatment
    • Senkbeil LE, Moss JG, Gaglio PJ, et al. Erythropoietin maintains ribavirin dose and sustained virologic response during HCV treatment. Hepatology 2003;38(Suppl 1):744A
    • (2003) Hepatology , vol.38 , Issue.SUPPL. 1
    • Senkbeil, L.E.1    Moss, J.G.2    Gaglio, P.J.3
  • 24
    • 0034795027 scopus 로고    scopus 로고
    • Management strategies for ribavirin-induced hemolytic anemia in the treatment of hepatitis C: Clinical and economic implications
    • Devine EB, Kowdley KV, Veenstra DL, Sullivan SD. Management strategies for ribavirin-induced hemolytic anemia in the treatment of hepatitis C: clinical and economic implications. Value Health 2001;4:376-84
    • (2001) Value Health , vol.4 , pp. 376-384
    • Devine, E.B.1    Kowdley, K.V.2    Veenstra, D.L.3    Sullivan, S.D.4
  • 25
    • 0030795196 scopus 로고    scopus 로고
    • Pilot study of the combination of interferon alfa and ribavirin as therapy of recurrent hepatitis C after liver transplantation
    • Bizollon T, Palazzo U, Ducerf C, et al. Pilot study of the combination of interferon alfa and ribavirin as therapy of recurrent hepatitis C after liver transplantation. Hepatology 1997;26:400-4
    • (1997) Hepatology , vol.26 , pp. 400-404
    • Bizollon, T.1    Palazzo, U.2    Ducerf, C.3
  • 26
    • 0033056569 scopus 로고    scopus 로고
    • Treatment of severe recurrent hepatitis C after liver transplantation with ribavirin plus interferon-alpha
    • Fischer L, Sterneck M, Valentin-Gamazo C, et al. Treatment of severe recurrent hepatitis C after liver transplantation with ribavirin plus interferon-alpha. Transplant Proc 1999;31:494-5
    • (1999) Transplant Proc , vol.31 , pp. 494-495
    • Fischer, L.1    Sterneck, M.2    Valentin-Gamazo, C.3
  • 27
    • 0029914375 scopus 로고    scopus 로고
    • Long-term outcome of hepatitis C infection after liver transplantation
    • Gane EJ, Portmann BC, Naoumov NV, et al. Long-term outcome of hepatitis C infection after liver transplantation. New Engl J Med 1996;334:815-20
    • (1996) New Engl J Med , vol.334 , pp. 815-820
    • Gane, E.J.1    Portmann, B.C.2    Naoumov, N.V.3
  • 28
    • 12844279849 scopus 로고    scopus 로고
    • High-dose ribavirin in combination with standard dose peginterferon for treatment of patients with chronic hepatitis C
    • Lindahl K, Stahle L, Bruchfeld A, Schvarcz R. High-dose ribavirin in combination with standard dose peginterferon for treatment of patients with chronic hepatitis C. Hepatology 2005;41:275-9
    • (2005) Hepatology , vol.41 , pp. 275-279
    • Lindahl, K.1    Stahle, L.2    Bruchfeld, A.3    Schvarcz, R.4
  • 29
    • 84882539857 scopus 로고    scopus 로고
    • NJ, Thomson PDR;
    • Anon. Red book. Montvale (NJ): Thomson PDR; 2005
    • (2005) Montvale
    • Anon1    Red book2
  • 30
    • 34347243596 scopus 로고    scopus 로고
    • Available from URL:, accessed March 12, 2007
    • Drugstore.com. Available from URL: http://www.drugstore.com/ [accessed March 12, 2007]
  • 32
    • 34347219144 scopus 로고    scopus 로고
    • Centers for Medicare and Medicaid Services, CY2005 November 17, Available from URL:, accessed December 15
    • Centers for Medicare and Medicaid Services. Clinical Laboratory Fee Schedule CY2005 November 17, 2004. Available from URL: http://www.cms.hhs.gov/ providers/pufdownload/clfdown.asp [accessed December 15, 2005]
    • (2004) Clinical Laboratory Fee Schedule
  • 33
    • 34347222596 scopus 로고    scopus 로고
    • Centers for Medicare and Medicaid Services, Available from URL:, accessed December 15
    • Centers for Medicare and Medicaid Services. Medicare Physician Fee Schedule. Available from URL: http://www.cms.hhs.gov/physicians/mpfsapp/step0. asp [accessed December 15, 2005]
    • (2005) Medicare Physician Fee Schedule
  • 34
    • 0033897666 scopus 로고    scopus 로고
    • Cost-effectiveness of epoetin alpha to augment preoperative autologous blood donation in elective cardiac surgery
    • Coyle D, Lee KM, Fergusson DA, Laupacis A. Cost-effectiveness of epoetin alpha to augment preoperative autologous blood donation in elective cardiac surgery. Pharmacoeconomics 2000;18:161-71
    • (2000) Pharmacoeconomics , vol.18 , pp. 161-171
    • Coyle, D.1    Lee, K.M.2    Fergusson, D.A.3    Laupacis, A.4
  • 35
    • 17144396268 scopus 로고    scopus 로고
    • Cost-effectiveness of recombinant human erythropoietin for reducing red blood cells transfusions in critically ill patients
    • MacLaren R, Sullivan PW. Cost-effectiveness of recombinant human erythropoietin for reducing red blood cells transfusions in critically ill patients. Value in Health 2005;8:105-16
    • (2005) Value in Health , vol.8 , pp. 105-116
    • MacLaren, R.1    Sullivan, P.W.2
  • 36
    • 26244451543 scopus 로고    scopus 로고
    • Erythropoietic growth factors for treatment-induced anemia in hepatitis C: A cost-effectiveness analysis
    • Spiegel BM, Chen K, Chiou CF, et al. Erythropoietic growth factors for treatment-induced anemia in hepatitis C: a cost-effectiveness analysis. Clin Gastroenterol Hepatol 2005;3:1034-42
    • (2005) Clin Gastroenterol Hepatol , vol.3 , pp. 1034-1042
    • Spiegel, B.M.1    Chen, K.2    Chiou, C.F.3
  • 37
    • 34347223304 scopus 로고    scopus 로고
    • Administration of erythropoietin for hepatitis C treatment-related anemia is not cost-effective
    • Campbell MS, Sun JC, Lee BY, et al. Administration of erythropoietin for hepatitis C treatment-related anemia is not cost-effective. Hepatology 2005;42(Suppl 1):346A
    • (2005) Hepatology , vol.42 , Issue.SUPPL. 1
    • Campbell, M.S.1    Sun, J.C.2    Lee, B.Y.3
  • 38
    • 33845641280 scopus 로고    scopus 로고
    • Cost-effectiveness of hematologic growth factors for anemia occurring during hepatitis C combination therapy
    • Del Rio RA, Post AB, Singer ME. Cost-effectiveness of hematologic growth factors for anemia occurring during hepatitis C combination therapy. Hepatology 2006;44:1598-606
    • (2006) Hepatology , vol.44 , pp. 1598-1606
    • Del Rio, R.A.1    Post, A.B.2    Singer, M.E.3
  • 39
    • 33845653886 scopus 로고    scopus 로고
    • The influence of cumulative peginterferon alpha-2a (40 Kda) and ribavirin (RBV) exposure on sustained virological response (SBR) rates in patients with genotype 1 chronic hepatitis C
    • Reddy KR, Hadziyannis SJ, Diago M, et al. The influence of cumulative peginterferon alpha-2a (40 Kda) and ribavirin (RBV) exposure on sustained virological response (SBR) rates in patients with genotype 1 chronic hepatitis C. J Hepatol 2005;42(Suppl 2):217
    • (2005) J Hepatol , vol.42 , Issue.SUPPL. 2 , pp. 217
    • Reddy, K.R.1    Hadziyannis, S.J.2    Diago, M.3
  • 40
    • 0036733269 scopus 로고    scopus 로고
    • Meta-analysis: Ribavirin-induced haemolytic anaemia in patients with chronic hepatitis C
    • Chang CH, Chen KY, Lai MY, Chan KA. Meta-analysis: ribavirin-induced haemolytic anaemia in patients with chronic hepatitis C. Aliment Pharmacol Ther 2002;16:1623-32
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 1623-1632
    • Chang, C.H.1    Chen, K.Y.2    Lai, M.Y.3    Chan, K.A.4
  • 41
    • 28944443558 scopus 로고    scopus 로고
    • Pure red cell aplasia global scientific advisory board (GSAB). Erythropoietin-induced, antibody-mediated pure red cell aplasia
    • Rossert J; Pure red cell aplasia global scientific advisory board (GSAB). Erythropoietin-induced, antibody-mediated pure red cell aplasia. Eur J Clin Invest 2005;35(Suppl 3):95-9
    • (2005) Eur J Clin Invest , vol.35 , Issue.SUPPL. 3 , pp. 95-99
    • Rossert, J.1
  • 42
    • 34347222944 scopus 로고    scopus 로고
    • Principles of good practice for budget impact analysis: Report of the ISPOR task force on good research practices - budget impact analysis
    • Available from URL:, accessed: March 15, 2007
    • Mauskopf JA, Sullivan SD, Annemans L, et al. Principles of good practice for budget impact analysis: report of the ISPOR task force on good research practices - budget impact analysis. Value Health 2006:10. Available from URL: http://www.ispor.org/workpaper/budget_impact.asp [accessed: March 15, 2007]
    • (2006) Value Health , pp. 10
    • Mauskopf, J.A.1    Sullivan, S.D.2    Annemans, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.