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Volumn 30, Issue 2, 2007, Pages 162-168

Pharmacokinetics and pharmacodynamics of levofloxacin in critically ill patients with ventilator-associated pneumonia

Author keywords

Critically ill; Levofloxacin; Pharmacodynamics; Pharmacokinetics; Ventilator associated pneumonia

Indexed keywords

LEVOFLOXACIN;

EID: 34347267246     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2007.03.016     Document Type: Article
Times cited : (26)

References (41)
  • 1
    • 0035068279 scopus 로고    scopus 로고
    • Antibacterial treatment of invasive mechanical ventilation-associated pneumonia
    • Barcenilla F., Gasco E., Rello J., et al. Antibacterial treatment of invasive mechanical ventilation-associated pneumonia. Drugs Aging 18 (2001) 189-200
    • (2001) Drugs Aging , vol.18 , pp. 189-200
    • Barcenilla, F.1    Gasco, E.2    Rello, J.3
  • 2
    • 3042821856 scopus 로고    scopus 로고
    • Levofloxacin: update and perspectives on one of the original 'respiratory quinolones'
    • Fish D.N. Levofloxacin: update and perspectives on one of the original 'respiratory quinolones'. Expert Rev Anti Infect Ther 1 (2003) 371-387
    • (2003) Expert Rev Anti Infect Ther , vol.1 , pp. 371-387
    • Fish, D.N.1
  • 3
    • 13644269309 scopus 로고    scopus 로고
    • American Thoracic Society; Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 2005;171:388-416.
  • 4
    • 33645836165 scopus 로고    scopus 로고
    • Levofloxacin in the treatment of ventilator-associated pneumonia
    • Alvarez-Lerma F., Grau S., and Alvarez-Beltran M. Levofloxacin in the treatment of ventilator-associated pneumonia. Clin Microbiol Infect 12 Suppl. 3 (2006) 81-92
    • (2006) Clin Microbiol Infect , vol.12 , Issue.SUPPL. 3 , pp. 81-92
    • Alvarez-Lerma, F.1    Grau, S.2    Alvarez-Beltran, M.3
  • 5
    • 13944264298 scopus 로고    scopus 로고
    • Levofloxacin for treatment of ventilator-associated pneumonia: a subgroup analysis from a randomized trial
    • Shorr A.F., Zadeikis N., Jackson W.L., et al. Levofloxacin for treatment of ventilator-associated pneumonia: a subgroup analysis from a randomized trial. Clin Infect Dis 40 Suppl 2 (2005) S123-S129
    • (2005) Clin Infect Dis , vol.40 , Issue.SUPPL. 2
    • Shorr, A.F.1    Zadeikis, N.2    Jackson, W.L.3
  • 6
    • 0037707561 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of intravenous levofloxacin in patients with early-onset ventilator-associated pneumonia
    • Pea F., Di Qual E., Cusenza A., Brollo L., Baldassarre M., and Furlanut M. Pharmacokinetics and pharmacodynamics of intravenous levofloxacin in patients with early-onset ventilator-associated pneumonia. Clin Pharmacokinet 42 (2003) 589-598
    • (2003) Clin Pharmacokinet , vol.42 , pp. 589-598
    • Pea, F.1    Di Qual, E.2    Cusenza, A.3    Brollo, L.4    Baldassarre, M.5    Furlanut, M.6
  • 7
    • 25144470553 scopus 로고    scopus 로고
    • Antimicrobial therapy in critically ill patients: a review of pathophysiological conditions responsible for altered disposition and pharmacokinetic variability
    • Pea F., Viale P., and Furlanut M. Antimicrobial therapy in critically ill patients: a review of pathophysiological conditions responsible for altered disposition and pharmacokinetic variability. Clin Pharmacokinet 44 (2005) 1009-1034
    • (2005) Clin Pharmacokinet , vol.44 , pp. 1009-1034
    • Pea, F.1    Viale, P.2    Furlanut, M.3
  • 8
    • 0036795265 scopus 로고    scopus 로고
    • Pharmacokinetics of intravenous and oral levofloxacin in critically ill adults in a medical intensive care unit
    • Rebuck J.A., Fish D.N., and Abraham E. Pharmacokinetics of intravenous and oral levofloxacin in critically ill adults in a medical intensive care unit. Pharmacotherapy 22 (2002) 1216-1225
    • (2002) Pharmacotherapy , vol.22 , pp. 1216-1225
    • Rebuck, J.A.1    Fish, D.N.2    Abraham, E.3
  • 10
    • 12244295467 scopus 로고    scopus 로고
    • Pharmacokinetics and intrapulmonary diffusion of levofloxacin in critically ill patients with severe community-acquired pneumonia
    • Boselli E., Breilh D., Rimmele T., et al. Pharmacokinetics and intrapulmonary diffusion of levofloxacin in critically ill patients with severe community-acquired pneumonia. Crit Care Med 33 (2005) 104-109
    • (2005) Crit Care Med , vol.33 , pp. 104-109
    • Boselli, E.1    Breilh, D.2    Rimmele, T.3
  • 11
    • 33744957178 scopus 로고    scopus 로고
    • Do intensive care patients need an individualized dosing regimen for levofloxacin?
    • Tayab Z.R., Hochhaus G., Kaufmann S., Jager D., and Barth J. Do intensive care patients need an individualized dosing regimen for levofloxacin?. Int J Clin Pharmacol Ther 44 (2006) 262-269
    • (2006) Int J Clin Pharmacol Ther , vol.44 , pp. 262-269
    • Tayab, Z.R.1    Hochhaus, G.2    Kaufmann, S.3    Jager, D.4    Barth, J.5
  • 12
    • 0025809112 scopus 로고
    • Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic 'blind' bronchoalveolar lavage fluid
    • Pugin J., Auckenthaler R., Mili N., Janssens J.P., Lew P.D., and Suter P.M. Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic 'blind' bronchoalveolar lavage fluid. Am Rev Respir Dis 143 (1991) 1121-1129
    • (1991) Am Rev Respir Dis , vol.143 , pp. 1121-1129
    • Pugin, J.1    Auckenthaler, R.2    Mili, N.3    Janssens, J.P.4    Lew, P.D.5    Suter, P.M.6
  • 13
    • 0037172355 scopus 로고    scopus 로고
    • Separation of levofloxacin, ciprofloxacin, gatifloxacin, moxifloxacin, trovafloxacin and cinoxacin by high-performance liquid chromatography: application to levofloxacin determination in human plasma
    • Liang H., Kays M.B., and Sowinski K.M. Separation of levofloxacin, ciprofloxacin, gatifloxacin, moxifloxacin, trovafloxacin and cinoxacin by high-performance liquid chromatography: application to levofloxacin determination in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci 772 (2002) 53-63
    • (2002) J Chromatogr B Analyt Technol Biomed Life Sci , vol.772 , pp. 53-63
    • Liang, H.1    Kays, M.B.2    Sowinski, K.M.3
  • 14
    • 18844452358 scopus 로고    scopus 로고
    • Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update
    • Mouton J.W., Dudley M.N., Cars O., Derendorf H., and Drusano G.L. Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs: an update. J Antimicrob Chemother 55 (2005) 601-607
    • (2005) J Antimicrob Chemother , vol.55 , pp. 601-607
    • Mouton, J.W.1    Dudley, M.N.2    Cars, O.3    Derendorf, H.4    Drusano, G.L.5
  • 15
    • 0032515386 scopus 로고    scopus 로고
    • Pharmacodynamics of levofloxacin: a new paradigm for early clinical trials
    • Preston S.L., Drusano G.L., Berman A.L., et al. Pharmacodynamics of levofloxacin: a new paradigm for early clinical trials. JAMA 279 (1998) 125-129
    • (1998) JAMA , vol.279 , pp. 125-129
    • Preston, S.L.1    Drusano, G.L.2    Berman, A.L.3
  • 16
    • 0035054726 scopus 로고    scopus 로고
    • Comparative pharmacokinetics and pharmacodynamics of the newer fluoroquinolone antibacterials
    • Aminimanizani A., Beringer P., and Jelliffe R. Comparative pharmacokinetics and pharmacodynamics of the newer fluoroquinolone antibacterials. Clin Pharmacokinet 40 (2001) 169-187
    • (2001) Clin Pharmacokinet , vol.40 , pp. 169-187
    • Aminimanizani, A.1    Beringer, P.2    Jelliffe, R.3
  • 18
    • 0141781235 scopus 로고    scopus 로고
    • Fluoroquinolone AUIC break points and the link to bacterial killing rates. Part 2: human trials
    • Schentag J.J., Meagher A.K., and Forrest A. Fluoroquinolone AUIC break points and the link to bacterial killing rates. Part 2: human trials. Ann Pharmacother 37 (2003) 1478-1488
    • (2003) Ann Pharmacother , vol.37 , pp. 1478-1488
    • Schentag, J.J.1    Meagher, A.K.2    Forrest, A.3
  • 19
    • 33644666801 scopus 로고    scopus 로고
    • Relationship of minimal inhibitory concentration and bactericidal activity to efficacy of antibiotics for treatment of ventilator-associated pneumonia
    • Kiem S., and Schentag J.J. Relationship of minimal inhibitory concentration and bactericidal activity to efficacy of antibiotics for treatment of ventilator-associated pneumonia. Semin Respir Crit Care Med 27 (2006) 51-67
    • (2006) Semin Respir Crit Care Med , vol.27 , pp. 51-67
    • Kiem, S.1    Schentag, J.J.2
  • 21
    • 0030030549 scopus 로고    scopus 로고
    • Twenty-four-hour area under the concentration-time curve/MIC ratio as a generic predictor of fluoroquinolone antimicrobial effect by using three strains of Pseudomonas aeruginosa and an in vitro pharmacodynamic model
    • Madaras-Kelly K.J., Ostergaard B.E., Hovde L.B., and Rotschafer J.C. Twenty-four-hour area under the concentration-time curve/MIC ratio as a generic predictor of fluoroquinolone antimicrobial effect by using three strains of Pseudomonas aeruginosa and an in vitro pharmacodynamic model. Antimicrob Agents Chemother 40 (1996) 627-632
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 627-632
    • Madaras-Kelly, K.J.1    Ostergaard, B.E.2    Hovde, L.B.3    Rotschafer, J.C.4
  • 22
    • 0141963048 scopus 로고    scopus 로고
    • Treatment and outcome of Pseudomonas aeruginosa bacteraemia: an antibiotic pharmacodynamic analysis
    • Zelenitsky S.A., Harding G.K., Sun S., Ubhi K., and Ariano R.E. Treatment and outcome of Pseudomonas aeruginosa bacteraemia: an antibiotic pharmacodynamic analysis. J Antimicrob Chemother 52 (2003) 668-674
    • (2003) J Antimicrob Chemother , vol.52 , pp. 668-674
    • Zelenitsky, S.A.1    Harding, G.K.2    Sun, S.3    Ubhi, K.4    Ariano, R.E.5
  • 23
    • 0032957758 scopus 로고    scopus 로고
    • Pharmacodynamics of levofloxacin and ciprofloxacin against Streptococcus pneumoniae
    • Lister P.D., and Sanders C.C. Pharmacodynamics of levofloxacin and ciprofloxacin against Streptococcus pneumoniae. J Antimicrob Chemother 43 (1999) 79-86
    • (1999) J Antimicrob Chemother , vol.43 , pp. 79-86
    • Lister, P.D.1    Sanders, C.C.2
  • 24
    • 0032978288 scopus 로고    scopus 로고
    • Pharmacodynamic comparisons of levofloxacin, ciprofloxacin, and ampicillin against Streptococcus pneumoniae in an in vitro model of infection
    • Lacy M.K., Lu W., Xu X., et al. Pharmacodynamic comparisons of levofloxacin, ciprofloxacin, and ampicillin against Streptococcus pneumoniae in an in vitro model of infection. Antimicrob Agents Chemother 43 (1999) 672-677
    • (1999) Antimicrob Agents Chemother , vol.43 , pp. 672-677
    • Lacy, M.K.1    Lu, W.2    Xu, X.3
  • 26
    • 0034988271 scopus 로고    scopus 로고
    • Pharmacodynamics of moxifloxacin, levofloxacin and sparfloxacin against Streptococcus pneumoniae
    • Lister P.D., and Sanders C.C. Pharmacodynamics of moxifloxacin, levofloxacin and sparfloxacin against Streptococcus pneumoniae. J Antimicrob Chemother 47 (2001) 811-818
    • (2001) J Antimicrob Chemother , vol.47 , pp. 811-818
    • Lister, P.D.1    Sanders, C.C.2
  • 27
    • 0034956119 scopus 로고    scopus 로고
    • Pharmacodynamic assessment of gatifloxacin against Streptococcus pneumoniae
    • Mattoes H.M., Banevicius M., Li D., et al. Pharmacodynamic assessment of gatifloxacin against Streptococcus pneumoniae. Antimicrob Agents Chemother 45 (2001) 2092-2097
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 2092-2097
    • Mattoes, H.M.1    Banevicius, M.2    Li, D.3
  • 28
    • 0034812780 scopus 로고    scopus 로고
    • Pharmacodynamics of fluoroquinolones against Streptococcus pneumoniae in patients with community-acquired respiratory tract infections
    • Ambrose P.G., Grasela D.M., Grasela T.H., Passarell J., Mayer H.B., and Pierce P.F. Pharmacodynamics of fluoroquinolones against Streptococcus pneumoniae in patients with community-acquired respiratory tract infections. Antimicrob Agents Chemother 45 (2001) 2793-2797
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 2793-2797
    • Ambrose, P.G.1    Grasela, D.M.2    Grasela, T.H.3    Passarell, J.4    Mayer, H.B.5    Pierce, P.F.6
  • 29
    • 0036136636 scopus 로고    scopus 로고
    • Pharmacodynamics of gatifloxacin against Streptococcus pneumoniae in an in vitro pharmacokinetic model: impact of area under the curve/MIC ratios on eradication
    • Lister P.D. Pharmacodynamics of gatifloxacin against Streptococcus pneumoniae in an in vitro pharmacokinetic model: impact of area under the curve/MIC ratios on eradication. Antimicrob Agents Chemother 46 (2002) 69-74
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 69-74
    • Lister, P.D.1
  • 30
    • 0037259153 scopus 로고    scopus 로고
    • Impact of AUC/MIC ratios on the pharmacodynamics of the des-F(6) quinolone garenoxacin (BMS-284756) is similar to other fluoroquinolones
    • Lister P.D. Impact of AUC/MIC ratios on the pharmacodynamics of the des-F(6) quinolone garenoxacin (BMS-284756) is similar to other fluoroquinolones. J Antimicrob Chemother 51 (2003) 199-202
    • (2003) J Antimicrob Chemother , vol.51 , pp. 199-202
    • Lister, P.D.1
  • 31
    • 2442549489 scopus 로고    scopus 로고
    • Relationship between fluoroquinolone area under the curve: minimum inhibitory concentration ratio and the probability of eradication of the infecting pathogen, in patients with nosocomial pneumonia
    • Drusano G.L., Preston S.L., Fowler C., Corrado M., Weisinger B., and Kahn J. Relationship between fluoroquinolone area under the curve: minimum inhibitory concentration ratio and the probability of eradication of the infecting pathogen, in patients with nosocomial pneumonia. J Infect Dis 189 (2004) 1590-1597
    • (2004) J Infect Dis , vol.189 , pp. 1590-1597
    • Drusano, G.L.1    Preston, S.L.2    Fowler, C.3    Corrado, M.4    Weisinger, B.5    Kahn, J.6
  • 32
    • 34347219245 scopus 로고    scopus 로고
    • Clinical and Laboratory Standard Institute. Performance standards for antimicrobial susceptibility testing. Fifteenth Informational Supplement. M100-S15. Wayne, PA: CLSI; 2005.
  • 33
    • 0027132478 scopus 로고
    • A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study
    • Le Gall J.R., Lemeshow S., and Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 270 (1993) 2957-2963
    • (1993) JAMA , vol.270 , pp. 2957-2963
    • Le Gall, J.R.1    Lemeshow, S.2    Saulnier, F.3
  • 34
    • 0020520245 scopus 로고
    • Protein binding of beta-lactams: the effects on activity and pharmacology particularly tissue penetration. II. Studies in man
    • Wise R. Protein binding of beta-lactams: the effects on activity and pharmacology particularly tissue penetration. II. Studies in man. J Antimicrob Chemother 12 (1983) 105-118
    • (1983) J Antimicrob Chemother , vol.12 , pp. 105-118
    • Wise, R.1
  • 35
    • 0036343731 scopus 로고    scopus 로고
    • Clinical role of protein binding of quinolones
    • Bergogne-Berezin E. Clinical role of protein binding of quinolones. Clin Pharmacokinet 41 (2002) 741-750
    • (2002) Clin Pharmacokinet , vol.41 , pp. 741-750
    • Bergogne-Berezin, E.1
  • 36
    • 34347266695 scopus 로고    scopus 로고
    • Theuretzbacher U. Tissue concentrations; protein binding. In: 14th International Society of Anti-Infective Pharmacology (ISAP) Educational Workshop, Pharmacokinetics and Pharmacodynamics of Anti-Infective Agents; 1 April 2006; Nice, France. http://www.isap.org/2006/ECCMID-ISAP-Workshop-2006/slides/Theuretzbacher .pdf. [accessed 5 March 2007].
  • 37
    • 34347239447 scopus 로고    scopus 로고
    • Sigma. Mueller-Hinton agar datasheet. http://www.sigmaaldrich.com/sigma/datasheet/m9552dat.pdf [accessed 5 March 2007].
  • 38
    • 1942476132 scopus 로고    scopus 로고
    • Measuring the effects of supratherapeutic doses of levofloxacin on healthy volunteers using four methods of QT correction and periodic and continuous ECG recordings
    • Noel G.J., Goodman D.B., Chien S., Solanki B., Padmanabhan M., and Natarajan J. Measuring the effects of supratherapeutic doses of levofloxacin on healthy volunteers using four methods of QT correction and periodic and continuous ECG recordings. J Clin Pharmacol 44 (2004) 464-473
    • (2004) J Clin Pharmacol , vol.44 , pp. 464-473
    • Noel, G.J.1    Goodman, D.B.2    Chien, S.3    Solanki, B.4    Padmanabhan, M.5    Natarajan, J.6
  • 39
    • 0032708146 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of fluoroquinolones
    • Turnidge J. Pharmacokinetics and pharmacodynamics of fluoroquinolones. Drugs 58 Suppl. 2 (1999) 29-36
    • (1999) Drugs , vol.58 , Issue.SUPPL. 2 , pp. 29-36
    • Turnidge, J.1
  • 41
    • 34347233621 scopus 로고    scopus 로고
    • European Committee on Antimicrobial Susceptibility Testing. Clinical breakpoints. Basel, Switzerland: EUCAST; 2004. http://www.srga.org/eucastwt/MICTAB/index.html [accessed 5 March 2007].


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