Cyclosporin A reduces airway mucus secretion and mucociliary clearance in rats

Clinics

Volumn 62, Issue 3, 2007, Pages 345-352

  Pazetti, Rogerio ^a   Pego Fernandes, Paulo Manuel ^a   Ranzani, Otavio Tavares ^a   Parra, Edwin Roger ^a   Lorenzi Filho, Geraldo ^a   Jatene, Fabio B ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cyclosporine; Goblet cell; Mucin; Mucociliary clearance

Indexed keywords

EID: 34347259949     PISSN: 18075932     EISSN: None     Source Type: Journal    
DOI: 10.1590/S1807-59322007000300021     Document Type: Article

References (47)

1. Sadé J, Eliezer N, Silberberg A, Nevo AC: The role of mucus in transport by cilia. Am Rev Respir Dis. 1970;102:48-52.
2. Houtmeyers E, Gosselink R, Gayan-Ramirez G, Decramer M. Regulation of mucociliary clearance in health and disease. Eur Respir J. 1999;13:1177-88.
3. Speich R, van der Bij W. Epidemiology and management of infections after lung transplantation. Clin Infect Dis. 2001;33:S58-65.
4. Kahan BD, Welsh M, Rutzky LP. Challenges in cyclosporine therapy: the role of therapeutic monitoring by area under the curve monitoring. Ther Drug Monit. 1995;17:621-4.
5. Ruhlmann A, Nordheim A. Effects of the immunosuppressive drugs CsA and FK506 on intracellular signaling and gene regulation. Immunobiology. 1997;198:192-206.
6. Vaden SL. Cyclosporine and tacrolimus. Semin Vet Med Surg (Small Anim). 1997;12:161-6.
7. King MB, Jessurun J, Savik SK, Murray JJ, Hertz ML. Cyclosporine reduces development of obliterative bronchiolitis in a murine heterotopic airway model. Transplantation. 1997;63:528-32.
8. Ceyhan BB, Sungur M, Celikel CA, Celikel T. Effect of inhaled cyclosporin on the rat airway: histologic and bronchoalveolar lavage assessment. Respiration. 1998;65:71-8.
9. Wada K, Kaminuma O, Mori A, Nakata A Ogawa K, Kikkawa H, et al. IL-5 producing T cells that induce airway eosinophilia and hyperresponsiveness are suppressed by dexamethasone and cyclosporin A in mice. Int Arch Allergy Immunol. 1998;117:24-7.
10. Winter JB, Groen M, Welling S, van der Logt K, Wildevuur CRH, Prop J. Inadequate antibody response against respiratory viral infection in long-surviving rat lung allografts. Transplantation. 1995;59:1583-9.
11. Mihatsch MJ, Kyo M, Morozumi K, Yamaguchi Y, Nickeleit V, Ryffel B. The side-effects of ciclosporine-A and tacrolimus. Clin Nephrol. 1998;49:356-63.
12. Sovcikova A, Tulinska J, Kubova J, Liskova A, Syrova D, Horakova K. Effect of cyclosporin A in Lewis rats in vivo and HeLa cells in vitro. J Appl Toxicol. 2002;22:153-160.
13. Simon N, Morin C, Bruguerolle B, Tillement JP. Effects of trimetazidine on altered functions of rat kidney induced by cyclosporine. Therapie. 2001;56:583-7.
14. Khanna A, Li B, Stenzel KH, Suthanthiran M. Regulation of new DNA synthesis in mammalian cells by cyclosporine. Demonstration of a transforming growth factor beta-dependent mechanism of inhibition of cell growth. Transplantation. 1994;57:577-82.
15. Koskinen PK, Kallio EA, Krebs R, Lemstrom KB. A dose-dependent inhibitory effect of cyclosporine A on obliterative bronchiolitis of rat tracheal allografts. Am J Respir Crit Care Med. 1997;155:303-12.
16. Kano K, Kyo K, Yamada Y, Ito S, Ando T, Arisaka O. Comparison between pre- and posttreatment clinical and renal biopsies in children receiving low dose cyclosporine-A for 2 years for steroid-dependent nephrotic syndrome. Clin Nephrol. 1999;52:19-24.
17. Lacayo NJ, Lum BL, Becton DL, Weinstein H, Ravindranath Y, Chang MN, et al. Pharmacokinetic interactions of cyclosporine with etoposide and mitoxantrone in children with acute myeloid leukemia. Leukemia. 2002;16:920-7.
18. Guide for the care and use of laboratory animals. Institute of laboratory animal resources. National Research Council of the National Academy of Sciences. Washington, D.C. National Academy Press 1996;1-35.
19. Journal of the American Veterinary Medicine Association 2001;218, n.5.
20. King, M. Experimental models for studying mucociliary clearance. Eur Respir J. 1998;11:222-8.
21. Puchelle E, Zahm JM, Aug F. Methods of studying mucociliary function. Presse Med. 1988;17:479-84.
22. Rubin BK, Ramirez O, King M. Mucus-depleted frog palate as a model for the study of mucociliary clearance. J Appl Physiol. 1990;69:424-9.
23. Mowry RW. Alcian blue techniques for histochemical study of acidic carbohydrates. J Histochem Cytochem. 1956;4:407. Apud Harkema JR, Plopper CG, Hyde DM, St George JA. Regional differences in quantities of histochemically detectable mucosubstances in nasal, paranasal, and nasopharyngeal epithelium of the bonnet monkey. J Histochem Cytochem. 1987;35:279-86.
24. nd ed. Boston: PWS Publishers; 1986. p. 584.
25. Corsi RCC, Silva ABD, Santos JC, Santos SRCJ, Gemperli R, Ferreira MC. Kinetic disposition of the cyclosporin A after 2.5 mg/kg; 5.0 mg/kg and 10.0 mg/kg single dose subcutaneous administration. Experimental study in rats. Rev Hosp Clin Fac Med S Paulo. 1995;50(Suppl):30-4.
26. Atkinson K, Boland J, Bitton K, Biggs J. Blood and tissue distribution of cyclosporine in humans and mice. Transplant Proc. 1983;15:2430-6.
27. Smith J, Hows J, Gordon-Smith EC. In vitro stability and storage of cyclosporine in human serum and plasma. Transplant Proc. 1983;15:2422-6.
28. Lemaire M, Jillemont JP. Role of lipoproteins and erythrocytes in the in vitro binding and distribution of cyclosporin A in the blood. J Pharm Pharmacol. 1982;34:715-7.
29. Miraz W, Zink RA, Graf A. Distribution and transfer of cyclosporine among the various human lipoprotein classes. Transplant Proc. 1983;15:2426-31.
30. Kahan BD, Oates JA, Wood AJ. Cyclosporine in drug therapy. N Engl J Med. 1989;321:1725-8.
31. Ryffel B, Foxwell BM, Mihatsch MJ, Donatsch P, Maurer G. Biologic significance of cyclosporine metabolites. Transplant Proc. 1988;20:575-80.
32. Wassef R, Cohen Z, Langer B. Pharmacokinetic profiles of cyclosporine in rats. Influence of route of administration and dosage. Transplantation. 1985;40:489-93.
33. Lopez-Vidriero MT. Biochemical basis of physical properties of respiratory tract secretions. Eur J Respir Dis. 1987;71:130-5.
34. King M. Experimental models for studying mucociliary clearance. Eur Respir J. 1998;11:222-8.
35. King M. Relationship between mucus viscoelasticity and ciliary transport in guaran gel/frog palate model system. Biorheology. 1980;17:249-54.
36. Puchelle E, Zahm JM, Polu JM. Drug effects on viscoelasticity of mucus. Eur J Respir Dis. 1980; 61:195-208.
37. Lorenzi G, Böhm GM, Guimarães ET, Costa Vaz MA, King M, Saldiva PN. Correlation between rheological properties and in vitro ciliary transport of rat nasal mucus. Biorheology. 1992;29:433-40.
38. Widdicombe JH, Widdicombe JG. Regulation of human airway surface liquid. Respir Physiol. 1995;99:3-12.
39. Macchione M, Guimarães ET, Saldiva PHN, Lorenzi-Filho, G. Methods for studying respiratory mucus and mucus clearance. Braz J Med Biol Res. 1995;28:1347-55.
40. Boucher RC. New concepts of the pathogenesis of cystic fibrosis lung disease. Eur Respir J. 2004;23:146-58.
41. Matsui H, Grubb BR, Tarran R, Randell SH, Gatzy JT, Davis CW, et al. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell. 1998;95:1005-15.
42. Mall M, Grubb BR, Harkema JR, O'Neal WK, and Boucher RC. Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice. Nature Med. 2004;10:487-93.
43. Kim KC, McCracken K, Shin CY, Jo MJ, Lee CJ, Ko KH. Airway goblet cell mucin: its structure and regulation of secretion. Eur Respir J. 1997;10:2644-9.
44. Rose MC. Characterization of human tracheobronchial mucin glycoproteins. In: Ginsburg V, editor. Methods in enzymology. New York: Academic; 1989. vol. 179, p. 3-17. Apud Rose MC and Voynow JA. Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev. 2006;86:245-78.
45. Spicer SS, Mochizuki I, Setser ME, Martinez JR. Complex carbohydrates of rat tracheobronchial surface epithelium visualized ultrastructurally. Am J Anat. 1980;158:93-109.
46. Plopper CG, St. George JA, Nishio SJ, Etchison JR, Nettesheim P. Carbohydrate cytochemistry of tracheobronchial airway epithelium of the rabbit. J Histochem Cytochem. 1984;32:209-18.
47. Rose MC. Mucins: structure, function, and role in pulmonary diseases. Am J Physiol Lung Cell Mol Physiol. 1992;263:L413-L429.