Hemostatic abnormalities in patients with severe preeclampsia

Clinical and Applied Thrombosis/Hemostasis

Volumn 13, Issue 3, 2007, Pages 285-291

  Heilmann, Lothar ^a   Rath, Werner ^b   Pollow, Kunhard ^c  

^a Perinatal Center   (Germany)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Pregnancy; Severe preeclampsia; Thrombin generation; Thrombomodulin

Indexed keywords

D DIMER; FIBRINOGEN; THROMBOMODULIN; VON WILLEBRAND FACTOR;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HEMATOLOGIC DISEASE; HUMAN; MAJOR CLINICAL STUDY; PLASMA; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; THROMBOCYTE COUNT;

ADULT; BLOOD COAGULATION DISORDERS; COMORBIDITY; ENDOTHELIUM, VASCULAR; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; FIBRINOGEN; HEMOSTASIS; HUMANS; PLATELET COUNT; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY TRIMESTER, THIRD; THROMBOMODULIN;

EID: 34347259897     PISSN: 10760296     EISSN: None     Source Type: Journal    
DOI: 10.1177/1076029607299986     Document Type: Article

References (47)

1. Brown MA, Buddle ML Hypertension in pregnancy: maternal and fetal outcomes according to laboratory and clinical features. Med J Aust. 1996 ; 165: 360-365
2. Lip Gyh, Blann A. Von Willebrand factor: a marker of endothelial dysfunction in vascular disorders? Cardiovascular Res. 1997 ; 34: 255-265.
3. FitzGerald MP, Floro C., Siegel J., Hernandez E. Laboratory findings in hypertensive disorders of pregnancy. J Natl Med Assoc. 1996 ; 88: 794-798.
4. Pridjian G., Puschett JB Preeclampsia. Part 1: clinical and pathophysiologic considerations. Obstet Gynecol Surv. 2002 ; 57: 598-618.
5. Bellart J., Gilabert R., Fontcuberta J., Borrell M., Miralles RM, Cabero L. Coagulation and fibrinolysis parameters in normal and hypertensive pregnancies. Hypertens Pregnancy. 1998 ; 17: 115-123.
6. Lyall F., Greer IA The vascular endothelium in normal pregnancy and pre-eclampsia. Rev Reprod. 1996 ; 1: 107-116.
7. Lyall F., Greer IA Pre-eclampsia: a multifaceted vascular disorder of pregnancy. J Hypertens. 1994 ; 12: 1339-1345.
8. Von Dadelszen P., Magee LA, Roberts J. Subclassification of preeclampsia. Hypertens Pregnancy. 2003 ; 22: 143-148.
9. Bremme K., Östlund E., Almqvist I., Heinonen K., Blombäck M. Enhanced thrombin generation and fibrinolytic activity in normal pregnancy and the puerperium. Obstet Gynecol. 1992 ; 80: 132-137.
10. Francalanci I., Comeglio P., Liotta AA, et al. D-dimer concentrations during normal pregnancy, as measured by ELISA. Thromb Res. 1995 ; 78: 399-405.
11. Kjellberg U., Andersson NE, Rosen S., Tengborn L., Hellgren M. APC resistance and other haemostatic variables during pregnancy and puerperium. Thromb Haemost. 1999 ; 81: 527-531.
12. Kruithof Eko, Tran-Thang Ch, Gudinchet A., et al. Fibrinolysis in pregnancy: a study of plasminogen activator inhibitors. Blood. 1987 ; 69: 460-466.
13. O'Riordan MN, Higgins JR Haemostasis in normal and abnormal pregnancy. Best Pract Res Clin Obstet Gynaecol. 2003 ; 17: 385-396.
14. Sanchez-Luceros A., Meschengieser SS, Marchese C., et al. Factor VIII and von Willebrand factor changes during normal pregnancy and puerperium. Blood Coagul Fibrinolysis. 2003 ; 14: 647-651.
15. Sattar N., Greer IA, Rumley A., et al. A longitudinal study of the relationships between haemostatic, lipid, and oestradiol changes during normal human pregnancy. Thromb Haemost. 1999 ; 81: 71-75.
16. Holmes VA Changes in haemostasis during normal pregnancy: does homocysteine play a role in maintaining homeostasis ? Proc Nutr Society. 2003 ; 62: 479-493.
17. Schjetlein R., Abdelnoor M., Haugen G., Husby H., Sandset PM, Wisloff F. Hemostatic variables as independent predictors for fetal growth retardation in preeclampsia. Acta Obstet Gynecol. Scand 1999 ; 78: 191-197.
18. Hellgren M. Hemostasis during normal pregnancy and puerperium. Semin Thromb Hemost. 2003 ; 29: 125-130.
19. Barron WM, Heckerling P., Hibbard JU, Fisher S. Reducing unnecessary coagulation testing in hypertensive disorders of pregnancy. Obstet Gynecol. 1999 ; 94: 364-370.
20. Boffa MC Considering cellular thrombomodulin distribution and its modulating factors can facilitate the use of plasma thrombomodulin as a reliable endothelial marker? Haemostasis 1996 ; 26 (suppl 4). 233-243.
21. Thorp JM, White GC, Moake JL, Bowes WA Von Willebrand factor multimeric levels and patterns in patients with severe preeclampsia. Obstet Gynecol. 1990 ; 75: 163-167.
22. Brown MA, Lindheimer MD, de Swiet M., Van Assche A., Moutquin JM The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of hypertension in Pregnancy (ISSHP). Hypertens Pregnancy. 2001 ; 20: IX - XIV.
23. Koh SC, Anandakumar C., Montan S., Ratnam SS Plasminogen activators, plasminogen activator inhibitors and markers of intravascular coagulation in pre-eclampsia. Gynecol Obstet Invest. 1993 ; 35: 214-221.
24. Clark P., Brennand J., Conkie JA, McCall F., Greer IA, Walker ID Activated protein C sensitivity, protein C, protein S and coagulation in normal pregnancy. Thromb Haemost. 1998 ; 79: 1166-1170.
25. Clark P., Sattar N., Walker ID, Greer IA The Glasgow outcome, APCR and lipid (GOAL) pregnancy study: significance of pregnancy associated activated protein C resistance. Thromb Haemost. 2001 ; 85: 30-35.
26. Hayashi M., Inoue T., Hoshimoto K., Negishi H., Ohkura T., Inaba N. Characterization of five marker levels of the hemostatic system and endothelial status in normotensive pregnancy and pre-eclampsia. Eur J Haematol. 2002 ; 69: 297-302.
27. He S., Bremme K., Blombäck M. Fibrin D-Dimer levels in preeclamptic pregnancies with birth of small-for-gestationalage neonates. Hypertens Pregnancy. 1998 ; 17: 217-226.
28. Ho Ch-H, Yang Z-L. The predictive value of the hemostasis parameters in the development of preeclampsia. Thromb Haemost. 1992 ; 67: 214-218.
29. Van Wersch Jwj, Ubachs Jmh. Blood coagulation and fibrinolysis during normal pregnancy. Eur J Clin Chem Clin Biochem. 1991 ; 29: 45-50.
30. Boffa MC, Valsecchi L., Fausto A. Predictive value of plasma thrombomodulin in preeclampsia and gestational hypertension. Thromb Haemost. 1998 ; 79: 1092-1095.
31. Kobayashi T., Tokunaga N., Sugimura M., et al. Coagulation/ fbrinolysis disorder in patients with severe preeclampsia. Semin Thromb Hemost. 1999 ; 25: 451-454.
32. Trofatter KF Jr, Howell ML, Greenberg CS, Hage ML Use of the fibrin D-dimer in screening for coagulation abnormalities in preeclampsia. Obstet Gynecol. 1989 ; 73: 435-440.
33. Clark P., Walker ID, Greer I. Acquired activated protein C resistance in pregnancy and associated with increased thrombin generation and fetal weight. Lancet. 1999 ; 353: 292-293.
34. VanWijk MJ, Boer K., Berckmans RJ, et al. Enhanced coagulation activation in preeclampsia: the role of APC resistance, micro-particles and other plasma constituents. Thromb Haemost. 2002 ; 88: 415-420.
35. Bretelle F., Sabatier F., Desprez D., et al. Circulating microparticles: a marker of procoagulant state in normal pregnancy and pregnancy complicated by preeclampsia or intrauterine growth restriction. Thromb Haemost. 2003 ; 89: 486-492.
36. Metz J., Cincotta R., Francis M., DeRosa L., Balloch A. Screening for consumptive coagulopathy in preeclampsia. Int J Gynaecol Obstet. 1994 ; 46: 3-9.
37. Kobayashi T., Terao T. Preeclampsia as chronic disseminated intravascular coagulation. Gynecol Obstet Invest. 1987 ; 24: 170-178.
38. Saleh AA, Bottoms SF, Gerbasi FR, Mammen EF Hemostasis and diagnosis of preeclampsia. Thromb Res. 1994 ; 75: 163-171.
39. Paternoster DM, Stella A., Simioni P., Mussap M., Plebani M. Coagulation and plasma fibronectin parameters in HELLP syndrome. Int J Gynaecol Obstet. 1995 ; 50: 263-268.
40. Neiger R., Trofatter MO, Trofatter KF D-Dimer test for early detection of HELLP syndrome. South Med J. 1995 ; 88: 416-419.
41. Takano S., Kimura S., Ohdama S., Aoki N. Plasma Thrombomodulin in health and diseases. Blood. 1990 ; 76: 2024-2029.
42. Magriples U., Chan DW, Bruzek D., Copel JA, Hsu CD Thrombomodulin: a new marker for placental abruption. Thromb Haemost. 1999 ; 81: 32-34.
43. de Moerloose P., Mermillod N., Amiral J., Reber G. Thrombomodulin levels during normal pregnancy, at delivery and in the postpartum: comparison with tissue-type plasminogen activator and plasminogen activator inhibitor-1. Thromb Haemost. 1998 ; 79: 554-556.
44. Hsu CD, Copel JA, Chan DW Antepartum and postpartum Thrombomodulin levels in preeclamptic and normotensive pregnancies. J Soc Gynecol Investig. 1997 ; 4: 135-137.
45. Hsu CD, Iriye B., Johnson TR, Witter FR, Hong SF, Chan DW Elevated circulating Thrombomodulin in severe preeclampsia. Am J Obstet Gynecol. 1993 ; 169: 148-149.
46. Shaarawy M., Didy HE: Thrombomodulin, plasminogen activator inhibitor type 1 (PAI-1) and fibronectin as bio-markers of endothelial damage in preeclampsia and eclampsia. Int J Gynaecol Obstet. 1996 ; 55: 135-139.
47. Tomer A. Platelet activation as a marker for in vivo pro-thrombotic activity: Detection by flow cytometry. J Biol Regul Homeost Agents. 2004 ; 18: 172-177.