Considering cellular thrombomodulin distribution and its modulating factors can facilitate the use of plasma thrombomodulin as a reliable endothelial marker?

Pathophysiology of Haemostasis and Thrombosis

Volumn 26, Issue , 1996, Pages 233-243

  Boffa, Marie Claire ^a  

^a SAINT LOUIS HOSPITAL   (France)

Author keywords

Endothelial cells; Infection; Inflammation

Indexed keywords

CELL MARKER; THROMBOMODULIN;

BLOOD LEVEL; CONFERENCE PAPER; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INFECTION; INFLAMMATION; PRIORITY JOURNAL;

BIOLOGICAL MARKERS; ENDOTHELIUM, VASCULAR; HUMANS; NEOPLASM PROTEINS; ORGAN SPECIFICITY; REFERENCE VALUES; THROMBOMODULIN; VASCULAR DISEASES;

EID: 0029853964     PISSN: 14248832     EISSN: 14248840     Source Type: Journal    
DOI: 10.1159/000217304     Document Type: Article

References (79)

1. Esmon CT: The roles of protein C and thrombomodulin in the regulation of blood coagulation. J Biol Chem 1989;264:4743-4746
2. Bourin MC. Lundgren-Akerlund E, Lindahl U: Isolation and characterization of the glycosamino-glycan component of rabbit thrombomodulin proteoglycan. J Biol Chem 1990;265:15424-15431
3. Maruyama I, Bell CE, Majerus PW: Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta. J Cell Biol 1985;101:363-371
4. Ishii H, Majerus PW: Thrombomodulin is present in human plasma and urine. J Clin Invest 1985;76:2178-2181
5. Ishii H, Uchiyama H, Kazama M: Soluble thrombomodulin antigen in conditioned medium is increased by damage of endothelial cells. Thromb Haemost 1991;65:618-623
6. Takano S, Kimura S, Ohdama S, Aoki N: Plasma thrombomodulin in health and diseases. Blood 1990;76:2024-2029
7. Kodama S, Uchijima E, Nagai M, Mikawatani K, Hayashi T, Suzuki K: One-step sandwich enzyme immunoassay for soluble human thrombomodulin using monoclonal antibodies. Clin Chim Acta 1990;192:191-199
8. Ishii H, Nakano M, Tsubouchi J, et al.: Establishment of enzyme immunoassay of human thrombomodulin in plasma and urine using monoclonal antibodies. Thromb Haemost 1990;63:157-162
9. Amiral J, Adam M, Mimilla F, Larrivaz I, Chambrette B, Boffa MC: Design and validation of a new immunoassay for soluble forms of thrombomodulin and studies on plasma. Hybridoma 1994;13:205-213
10. Boffa MC, Aurousseau MH, Wiesel ML, Grunebaum L, Cazenave JP Variations of plasma thrombomodulin level due to sex and age. Blood (Abstract) 1991;78:S1-221
11. Wright HP: Endothelial turnover. Thromb Diath Haemorrh 1970;suppl 40:79-87
12. Wagner RC: Endothelial cell embryology and growth. Adv Microcirc 1980;9:45-75
13. Conway EM, Nowakowski B, Steiner-Mosonyi M: Human neutrophils synthesize thrombomodulin that does not promote thrombin-dependent protein C activation. Blood 1992;80:1254-1263
14. Blann AD, Taberner DA: A reliable marker of endothelial cell dysfunction: does it exists? Br J Haematol 1995;90:244-248
15. Boffa MC, Jackman RW, Peyri N, Boffa JF, George B: Thrombomodulin in the central nervous system. Nouv Rev Fr Hematol 1991;33:423-429
16. Boffa MC, Burke B, Haudenschild CC. Preservation of thrombomodulin antigen on vascular and extravascular surfaces. J Histochem Cytochem 1987;35:1267-1276
17. Pruna A, Peyri N, Berard M, Boffa MC. Thrombomodulin is synthesized by human mesangial cells. (Submitted)
18. Suzuki K, Nishioka J, Hayashi T, Kosaka Y: Functionally active thrombomodulin is present in human platelets. J Biochem (Tokyo) 1988; 104:628-632
19. Ogura M, Ito T, Maruyama I, et al.: Localization and biosynthesis of functional thrombomodulin in human megakaryocytes and a human megakaryoblastic cell line (MEG-01). Thromb Haemost 1990;64:297-301
20. McCachren SS, Diggs J, Weinberg JB, Dittman WA: Thrombomodulin expression by human blood monocytes and by human synovial tissue lining macrophages. Blood 1991;78:3128-3132
21. Grey ST, Hancock WW: A physiologic anti-inflammatory pathway based on thrombomodulin expression and generation of activated protein C by human mononuclear phagocytes. J Immunol 1996;156:2256-2263
22. Maillard C, Berruyer M, Serre CM, Amiral J, Dechavanne M, Delmas PD: Thrombomodulin is synthesized by osteoblasts, stimulated by 1,25-(OH)2D3 and activates protein C at their cell membrane. Endocrinology 1993;133:668-674
23. Mizutani H, Hayashi T, Nouchi N, et al.: Functional and immunoreactive thrombomodulin expressed by kératinocytes. J Invest Dermatol 1994;103:825-828
24. Raife TJ, Lager DJ, Madison KC, et al.: Thrombomodulin expression by human keratinocytes. Induction of cofactor activity during epidermal differentiation. J Clin Invest 1994;93:1846-1851
25. Senet P. Peyri N, Berard M, Dubertret L, Boffa MC: Thrombomodulin, a functional surface protein on human keratinocytes, is regulated by retinoic acid. (Submitted)
26. Imada S, Yamaguchi H, Nagumo M, Katayanagi S, Iwasaki H, Imada M. Identification of feto-modulin, a surface marker protein of fetal development, as thrombomodulin by gene cloning and functional assays. Dev Biol 1990:140:113-122.
27. Yonezawa S, Maruyama I, Sakae K, Igata A, Majerus PW, Sato E: Thrombomodulin as a marker for vascular tumors. Comparative study with factor VIII and Ulex europaeus I lectin. Am J Clin Pathol 1987;88:405-411
28. Ordonez NG: The immunohistochemical diagnosis of mesothelioma: differentiation of mesothelioma and lung adenocarcinoma. Am J Surg Pathol. 1989;13:276-291
29. Collins CL, Ordonez NG, Schaefer R, et al.: Thrombomodulin expression in malignant pleural mesothelioma and pulmonary adenocarcinoma. Am J Pathol 1992;141:827-833
30. Maruyama I, Majerus PW: The turnover of thrombin-thrombomodulin complex in cultured human umbilical vein endothelial cells and A549 lung cancer cells. Endocytosis and degradation of thrombin. J Biol Chem 1985;260:15432-15438
31. Tamura A, Matsubara O, Hirokawa K, Aoki N: Detection of thrombomodulin in human lung cancer cells. Am J Pathol 1993;142:79-85
32. Tezuka Y, Yonezawa S, Maruyama I, et al.: Expression of thrombomodulin in esophageal squamous cell carcinoma and its relationship to lymph node metastasis. Cancer Res 1995;55:4196-4200
33. Takebayashi Y, Yamada K, Maruyama I, Fujii R, Akiyama S, Aikou T: The expression of thymidine phosphorylase and thrombomodulin in human colorectal carcinomas. Cancer Lett 1995;92:1-7
34. Suehiro T, Shimada M, Matsumata T, Taketomi A, Yamamoto K, Sugimachi K: Thrombomodulin inhibits intrahepatic spread in human hepatocellular carcinoma. Hepatology 1995;21:1285-1290
35. Oikawa T, Kushuhara M, Ishikawa S, et al.: Production of endothelin-1 and thrombomodulin by human pancreatic cancer cells. Br J Cancer 1994;69:1059-1064
36. Wilhelm S, Wilhelm O, Schmitt M, Mobus V, Kreienberg R, Graeff H: Expression of the cell surface receptor for thrombin, thrombomodulin, in human ovarian cancer cells. Gynekol Geburtshilfliche Rundsch 1993;33 Suppl 1:202-203
37. Weiler-Guettler H, Yu K, Soff G, Gudas LJ, Rosenberg RD: Thrombomodulin gene regulation by cAMP and retinoic acid in F9 embryonal carcinoma cells. Proc Natl Acad Sci USA 1992;89:2155-2159
38. Wong VL, Hofman FM, Ishii H, Fisher M: Regional distribution of thrombomodulin in human brain. Brain Res 1991;556:1-5
39. Ishii H, Salem HH, Bell CE, Laposata EA, Majerus PW: Thrombomodulin, an endothelial anti coagulant protein, is absent from the human brain. Blood 1986;67:362-365
40. Rosenberg RD: The absence of the blood clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system. Thromb Haemost 1995;74:52-57
41. Fink LM, Eidt JF, Johnson K et al : Thrombomodulin activity and localization. Int J Dev Biol 1993;37:221
42. Hergesell O, Andrassy K, Geberth S, Nawroth P, Gabath S: Plasma thrombomodulin levels are dependent on renal function. Thromb Res 1993;72:455-458
43. Yoshida M, Kozaki M, Ioya N, et al.: Plasma thrombomodulin levels as an indicator of vascular injury caused by cyclosporine nephrotoxicity. Transplantation 1990:50:1066-1069
44. Ishii H, Kizaki K, Uchiyama H, Horie S, Kazama M: Cyclic AMP increases thrombomodulin expression on membrane surface of cultured human umbilical vein endothelial cells. Thromb Res 1990;59:841-850
45. Imada S, Yamaguchi H, Imada M: Differential expression of fetomodulin and tissue plasminogen activator to characterize parietal endoderm differentiation of F9 embryonal carcinoma cells. Dev Biol 1990;141:426-430
46. Maruyama I, Soejima Y, Osame M, et al.: Increased expression of thrombomodulin on the cultured human umbilical vein endothelial cells and mouse hemangioma cells by cyclic AMP. Thromb Res 1991;61:301-310
47. Hirokawa K, Aoki N: Regulatory mechanisms for thrombomodulin expression in human umbilical vein endothelial cells in vitro. J Cell Physiol 1991;147:157-165
48. Archipoff G, Beretz A, Bartha K, et al.: Role of cyclic AMP in promoting the thromboresistance of human endothelial cells by enhancing thrombomodulin and decreasing tissue factor activities. BrJ Pharmacol 1993;109:18-28
49. Horie S, Kizaki K, Ishii H, Kazama M: Retinoic acid stimulates expression of thrombomodulin, a cell surface anticoagulant glycoprotein, on human endothelial cells. Differences between up-regulation of thrombomodulin by retinoic acid and cyclic AMP. Biochem J 1992;281:149-154
50. Bartha K, Brisson C, Archipoff G, et al.: Thrombin regulates tissue factor and thrombomodulin mRNA levels and activities in human saphenous vein endothelial cells by distinct mechanisms. J Biol Chem 1993;268:421-429
51. Conway EM, Rosenberg RD: Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells. Mol Cell Biol 1988;8:5588-5592
52. Moore KL, Esmon CT, Esmon NL: Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture. Blood 1989;73:159-165
53. Lentz SR, Tsiang M. Sadler JE: Regulation of thrombomodulin by tumor necrosis factor-alpha: comparison of transcriptional and posttranscriptional mechanisms. Blood 1991;77:542-550
54. Archipoff G, Beretz A, Freyssinet JM, Klein-Soyer C, Brisson C, Cazenave JP: Heterogeneous regulation of constitutive thrombomodulin or inducible tissue-factor activities on the surface of human saphenous-vein endothelial cells in culture following stimulation by interleukin-1, tumour necrosis factor, thrombin or phorbol ester. Biochem J 1991;273:679-684
55. Hashimoto Y, Hirohata S, Kashiwado T, Itoh K. Ishii H: Cytokine regulation of hemostatic property and 1L-6 production of human endothelial cells. Inflammation 1992;16:613-621
56. Moore KL, Andreoli SP, Esmon NL, Esmon CT, Bang NU: Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro. J Clin Invest 1987;79:124-130
57. Ishii H. Horie S. Kizaki K, Kazama M: Retinoic acid counteracts both the downregulation of thrombomodulin and the induction of tissue factor in cultured human endothelial cells exposed to tumor necrosis factor. Blood 1992:80:2556-2562
58. Kapiotis S, Besemer J, Bevec D, et al.: Interleukin-4 counteracts pyrogen-induced downregulation of thrombomodulin in cultured human vascular endothelial cells. Blood 1991;78:410-415
59. Herbert JM, Savi P, Laplace MC, et al.: IL-4 and IL-13 exhibit comparable abilities to reduce pyrogen-induced expression of procoagulant activity in endothelial cells and monocytes. FEBS Lett 1993;328:268-270
60. Ogawa S, Gerlach H, Esposito C, Pasagian-Macaulay A, Brett J, Stem D. Hypoxia modulates the barrier and coagulant function of cultured bovine endothelium. Increased monolayer permeability and induction of procoagulant properties. J Clin Invest 1990;85:1090-1098.
61. Seigneur M, Dufourcq P, Belloc F, Lenoble M, Renard M, Boisseau MR: Influence of pentoxifylline on membrane thrombomodulin levels in endothelial cells submitted to hypoxic conditions. J Cardiovasc Pharmacol 1995;25:S85-S87
62. Ishii H, Kizaki K. Horie S, Kazama M. Oxidized low density lipoprotein reduces thrombomodulin transcription in cultured human endothelial cells through degradation of the lipoprotein in lysosomes. J Biol Chem 1996; 271: 8458-8465.
63. Lentz SR, Sadler JE: Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine. J Clin Invest 1991;88:1906-1914
64. Hayashi T, Honda G, Suzuki K: An atherogenic stimulus homocysteine inhibits cofactor activity of thrombomodulin and enhances thrombomodulin expression in human umbilical vein endothelial cells. Blood 1992;79:2930-2936
65. Slungaard A, Vercellotti GM, Tran T, Gleich GJ, Key NS: Eosinophil cationic granule proteins impair thrombomodulin function. A potential mechanism for thromboembolism in hypereosino-philic heart disease. J Clin Invest 1993;91:1721-1730
66. Conway EM, Liu L, Nowakowski B, Steiner-Mosonyi M, Jackman RW: Heat shock of vascular endothelial cells induces an up-regulatory transcriptional response of the thrombomodulin gene that is delayed in onset and does not attenuate. J Biol Chem 1994;269:22804-22810
67. Malek AM. Jackman R. Rosenberg RD, Izumo S: Endothelial expression of thrombomodulin is reversibly regulated by fluid shear stress. Circ Res 1994;74:852-860
68. Takada Y, Shinkai F, Kondo S, et al.: Fluid shear stress increases the expression of thrombomodulin by cultured human endothelial cells. Biochem Biophys Res Commun 1994:205:1345-1352
69. Morikawa Y, Morikawa A. Makino I: Relationship of thyroid states and serum thrombomodulin (TM) levels in patients with Graves' disease: TM. a possible new marker of the peripheral activity of thyroid hormones. J Clin Endocrinol Metab 1993;76:609-614
70. Abe H. Okajima K. Okabe H, Takatsuki K. Binder BR: Granulocyte proteases and hydrogen peroxide synergistically inactivate thrombomodulin of endothelial cells in vitro. J Lab Clin Med 1994:123:874-881
71. Boehme MWJ. Deng Y. Raeth U, et al.: Release of thrombomodulin from endothelial cells by concerted action of TNF-alpha and neutrophils: in vivo and in vitro studies. Immunology 1996:87:134-140
72. Bambang LS. Mazzucotelli JR Moczar M. Beaujean F. Loisance D: Effects of cryopreservation on the proliferation and anticoagulant activity of human saphenous vein endothelial cells. J Thorac Cardiovasc Surg 1995:110:998-1004
73. Rauen U, Erhard J, Kuhnhenrich P, et al.: Nonparenchymal cell and hepatocellular injury to human liver grafts assessed by enzyme-release into the perfusate. Langenbecks Arch Chir 1994;379:241-247
74. Esmon CT, Schwarz HP: An update on clinical and basic aspects of the protein C anticoagulant pathway. Trends Cardiovasc Med 1995:5:141-148.
75. Boffa MC. Valsecchi L, Fausto A, Vigano' D'Angelo S, Bérard M. Safa O, D'Angelo A: Significance of plasma thrombomodulin levels in preeclampsia: a prospective study in pregnancies at risk of preeclampsia. Thromb Haemost (Abstract) 1995:73:1302
76. Hemmer CJ, Bierhaus A, Von Riedesel J, et al.: Elevated thrombomodulin plasma levels as a result of endothelial involvement in plasmodium falciparum malaria. Thromb Haemost 1994:72:457-464.
77. George F, Brouqui P, Boffa MC, et al.demonstration of Rickettsia conorii-induced endothelial injury in vivo by measuring circulating endothelial cells, thrombomodulin, and von Willebrand factor in patients with Mediterranean spotted fever. Blood 1993; 82: 2109-2116.
78. Cacoub P, Karmochkine M, Dorent R, et al.: Plasma levels of thrombomodulin in pulmonary hypertension. Am J Med 1996; in press
79. Lindahl AK, Boffa MC, Abildgaard U: Increased plasma thrombomodulin in cancer patients. Thromb Haemost 1993;69:112-114.