Bone marrow stromal cells promoting corticospinal axon growth through the release of humoral factors in organotypic cocultures in neonatal rats

Journal of Neurosurgery: Spine

Volumn 6, Issue 5, 2007, Pages 412-419

  Kamei, Naosuke ^a   Tanaka, Nobuhiro ^a   Oishi, Yosuke ^b   Ishikawa, Masakazu ^a   Hamasaki, Takahiko ^a   Nishida, Koji ^a   Nakanishi, Kazuyoshi ^a   Sakai, Norio ^a   Ochi, Mitsuo ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b Department of Orthopedic Surgery Hamawaki Orthopaedic Hospital   (Japan)

Author keywords

Axon regeneration; Bone marrow stromal cell; Corticospinal tract; Humoral factor; Slice culture

Indexed keywords

1,1' DIOCTADECYL 3,3,3',3' TETRAMETHYLINDOCARBOCYANINE; BRAIN DERIVED NEUROTROPHIC FACTOR; GREEN FLUORESCENT PROTEIN; GROWTH FACTOR; HUMORAL ANTIBODY; MESSENGER RNA; VASCULOTROPIN; CILIARY NEUROTROPHIC FACTOR; VASCULOTROPIN A;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; BRAIN CORTEX; CELL DIFFERENTIATION; CELL REGENERATION; CELL TRANSPLANTATION; COCULTURE; CONTROLLED STUDY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MALE; NERVE FIBER GROWTH; NERVE FIBER TRANSPORT; NONHUMAN; PYRAMIDAL TRACT; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD; SPRAGUE DAWLEY RAT; STROMA CELL; ANIMAL; CYTOLOGY; METABOLISM; NERVE FIBER; NERVE REGENERATION; NEWBORN; PHYSIOLOGY;

ANIMALS; ANIMALS, NEWBORN; AXONS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; BRAIN-DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; COCULTURE TECHNIQUES; IMMUNOHISTOCHEMISTRY; NERVE REGENERATION; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPINAL CORD; STROMAL CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 34347254675     PISSN: 15475654     EISSN: None     Source Type: Journal    
DOI: 10.3171/spi.2007.6.5.412     Document Type: Article

References (35)

1. Bregman BS, McAtee M, Dai HN, Kuhn PL: Neurotrophic factors increase axonal growth after spinal cord injury and transplantation in the adult rat. Exp Neurol 148:475-494, 1997
2. Carmeliet P, Storkebaum E: Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders. Semin Cell Dev Biol 13:39-53, 2002
3. Chen X, Katakowski M, Li Y, Lu D, Wang L, Zhang L, et al: Human bone marrow stromal cell cultures conditioned by traumatic brain tissue extracts: growth factor production. J Neurosci Res 69:687-691, 2002
4. Chen X, Li Y, Wang L, Katakowski M, Zhang L, Chen J, et al: Ischemic rat brain extracts induce human marrow stromal cell growth factor production. Neuropathology 22:275-279, 2002
5. Chopp M, Zhang XH, Li Y, Wang L, Chen J, Lu D, et al: Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation. Neuroreport 11:3001-3005, 2000
6. Ito Y, Tanaka N, Fujimoto Y, Yasunaga Y, Ishida O, Agung M, et al: Bone formation using novel interconnected porous calcium hydroxyapatite ceramic hybridized with cultured marrow stromal stem cells derived from Green rat. J Biomed Mater Res Am 69:454-461, 2004
7. Ji JF, He BP, Dheen ST, Tay SS: Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury. Stem Cells 22:415-427, 2004
8. Jin K, Zhu Y, Sun Y, Mao XO, Xie L, Greenberg DA: Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc Natl Acad Sci U S A 99:11946-11950, 2002
9. Kamei N, Oishi Y, Tanaka N, Ishida O, Fujiwara Y, Ochi M: Neural progenitor cells promote corticospinal axon growth in organotypic co-cultures. Neuroreport 15:2579-2583, 2004
10. Kamei N, Tanaka N, Oishi Y, Hamasaki T, Nakanishi K, Sakai N, et al: BDNF, NT-3 and NGF released from transplanted neural progenitor cells promote corticospinal axon growth in organotypic co-cultures. Spine, in press
11. Karimi-Abdolrezaee S, Eftekharpour E, Wang J, Morshead CM, Fehlings MG: Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury. J Neurosci 26:3377-3389, 2006
12. Lambrechts D, Storkebaum E, Morimoto M, Del-Favero J, Desmet F, Marklund SL, et al: VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat Genet 34:383-394, 2003
13. Li Y, Chopp M, Chen J, Wang L, Gautam SC, Xu YX, et al: Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice. J Cereb Blood Flow Metab 20:1311-1319, 2000
14. Li Y, Field PM, Raisman G: Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells. Science 277:2000-2002, 1997
15. Lu P, Jones LL, Tuszynski MH: BDNF-expressing marrow stromal cells support extensive axonal growth at sites of spinal cord injury. Exp Neurol 191:344-360, 2005
16. Maniatopoulos C, Sodek J, Melcher AH: Bone formation in vitro by stromal cells obtained from bone marrow of young adult rats. Cell Tissue Res 254:317-330, 1988
17. McDonald JW, Liu XZ, Qu Y, Liu S, Mickey SK, Turetsky D, et al: Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat Med 5:1410-1412, 1999
18. Natsu K, Ochi M, Mochizuki Y, Hachisuka H, Yanada S, Yasunaga Y: Allogeneic bone marrow-derived mesenchymal stromal cells promote the regeneration of injured skeletal muscle without differentiation into myofibers. Tissue Eng 10:1093-1112, 2004
19. Neufeld G, Cohen T, Shraga N, Lange T, Kessler O, Herzog Y: The neuropilins: multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis. Trends Cardiovasc Med 12:13-19, 2002
20. Neuhuber B, Himes BT, Shumsky JS, Gallo G, Fischer I: Axon growth and recovery of function supported by human bone marrow stromal cells in the injured spinal cord exhibit donor variations. Brain Res 1035:73-85, 2005
21. Ohta M, Suzuki Y, Noda T, Ejiri Y, Dezawa M, Kataoka K, et al: Bone marrow stromal cells infused into the cerebrospinal fluid promote functional recovery of the injured rat spinal cord with reduced cavity formation. Exp Neurol 187:266-278, 2004
22. Oishi Y, Baratta J, Robertson RT, Steward O: Assessment of factors regulating axon growth between the cortex and spinal cord in organotypic co-cultures: effects of age and neurotrophic factors. J Neurotrauma 21:339-356, 2004
23. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al: Multilineage potential of adult human mesenchymal stem cells. Science 284:143-147, 1999
24. Pluchino S, Quattrini A, Brambilla E, Gritti A, Salani G, Dina G, et al: Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature 422:688-694, 2003
25. Quarto R, Mastrogiacomo M, Cancedda R, Kutepov SM, Mukhachev V, Lavroukov A, et al: Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med 344:385-386, 2001
26. Rosenstein JM, Krum JM: New roles for VEGF in nervous tissue - beyond blood vessels. Exp Neurol 187:246-253, 2004
27. Schratzberger P, Schratzberger G, Silver M, Curry C, Kearney M, Magner M, et al: Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy. Nat Med 6:405-413, 2000
28. Storkebaum E, Lambrechts D, Carmeliet P: VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection. Bioessays 26:943-954, 2004
29. Suzuki H, Taguchi T, Tanaka H, Kataoka H, Li Z, Muramatsu K, et al: Neurospheres induced from bone marrow stromal cells are multipotent for differentiation into neuron, astrocyte, and oligodendrocyte phenotypes. Biochem Biophys Res Commun 322:918-922, 2004
30. Vacanti MP, Leonard JL, Dore B, Bonassar LJ, Cao Y, Stachelek SJ, et al: Tissue-engineered spinal cord. Transplant Proc 33:592-598, 2001
31. Widenfalk J, Lipson A, Jubran M, Hofstetter C, Ebendal T, Cao Y, et al: Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury. Neuroscience 120:951-960, 2003
32. Wu S, Suzuki Y, Ejiri Y, Noda T, Bai H, Kitada M, et al: Bone marrow stromal cells enhance differentiation of cocultured neurosphere cells and promote regeneration of injured spinal cord. J Neurosci Res 72:343-351, 2003
33. Xu XM, Chen A, Guenard V, Kleitman N, Bunge MB: Bridging Schwann cell transplants promote axonal regeneration from both the rostral and caudal stumps of transected adult rat spinal cord. J Neurocytol 26:1-16, 1997
34. Ye JH, Houle JD: Treatment of the chronically injured spinal cord with neurotrophic factors can promote axonal regeneration from supraspinal neurons. Exp Neurol 143:70-81, 1997
35. Zhu Y, Jin K, Mao XO, Greenberg DA: Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression. FASEB J 17:186-193, 2003