Fine mapping of multiple QTL using combined linkage and linkage disequilibrium mapping - A comparison of single QTL and multi QTL methods

Genetics Selection Evolution

Volumn 39, Issue 3, 2007, Pages 285-299

  Ulberg, Eivind ^a   Meuwissen, Theo H E ^a  

^a NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

Author keywords

Fine mapping; Multiple QTL; Simulations

Indexed keywords

COMPARATIVE STUDY; DATA SET; DETECTION METHOD; MAPPING METHOD; MODELING;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CHROMOSOME MAP; COMPARATIVE STUDY; COMPUTER SIMULATION; CROSS BREEDING; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC LINKAGE; GENETIC MARKER; MALE; PEDIGREE; POPULATION GENETICS; QUANTITATIVE TRAIT LOCUS;

ANIMALS; COMPUTER SIMULATION; CROSSES, GENETIC; FEMALE; GENETIC MARKERS; GENETICS, POPULATION; LINKAGE (GENETICS); LINKAGE DISEQUILIBRIUM; MALE; MODELS, GENETIC; PEDIGREE; PHYSICAL CHROMOSOME MAPPING; QUANTITATIVE TRAIT LOCI;

EID: 34347248771     PISSN: 0999193X     EISSN: 12979686     Source Type: Journal    
DOI: 10.1051/gse:2007004     Document Type: Article

References (15)

1. Farnir F., Grisart B., Coppieters W., Riquet J., Berzi P., Cambisano N., Karim L., Mni M., Moisio S., Simon P., Wagenaar D., Vilkki J., Georges M., Simultaneous mining of linkage and linkage disequilibrium to fine map quantitative trait loci in outbred half-sib pedigrees: revisiting the location of a quantitative trait locus with major effect on milk production on bovine chromosome 14, Genetics 161 (2002) 275-287.
2. Gilmour A.R., Cullis B.R., Welham S.J., Thompson R., ASREML Reference Manual (2000) ftp.res.bbsrc.ac.uk/pub/aar
3. Jansen R.C., Stam P., High resolution of quantitative traits into multiple loci via interval mapping, Genetics 136 (1994) 1447-1455.
4. Lund M.S., Sørensen P., Guldbrandtsen B., Sorensen D.A., Multitrait fine mapping of quantitative trait loci using combined linkage disequilibria and linkage analysis, Genetics 163 (2003) 405-410.
5. Maccluer J.W., Vandeberg J.L., Read B., Ryder O.A., Pedigree analysis by computer simulation, Zoo Biol. 5 (1986) 147-160.
6. Martinez O., Curnow R.N., Estimating the locations and the sizes of the effects of quantitative trait loci using flanking markers, Theor. Appl. Genet. 85 (1992) 480-488.
7. Meuwissen T.H.E., Goddard M.E., Fine mapping of quantitative trait loci using linkage disequilibria with closely linked marker loci, Genetics 155 (2000) 421-430.
8. Meuwissen T.H.E., Goddard M.E., Prediction of identity by descent probabilities from marker-haplotypes, Genet. Sel. Evol. 33 (2001) 605-634.
9. Meuwissen T.H.E., Goddard M.E., Mapping multiple QTL by combined linkage disequilibrium/linkage analysis in outbred populations, Proceedings of the 7th World Congress on Genetics Applied to Livestock Production, 2002, Montpellier, France, Communication 21-18.
10. Meuwissen T.H.E., Goddard M.E., Mapping multiple QTL using linkage disequilibrium and linkage analysis information and multitrait data, Genet. Sel. Evol. 36 (2004) 261-279.
11. Meuwissen T.H.E., Hayes B.J., Goddard M.E., Prediction of total genetic value using genome-wide dense marker maps, Genetics 157 (2001) 1819-1829.
12. Meuwissen T.H.E., Karlsen A., Lien S., Olsaker I., Goddard M.E., Fine mapping of a quantitative trait locus for twinning rate using combined linkage and linkage disequilibrium mapping, Genetics 161 (2002) 373-379.
13. Olsen H.G., Lien S., Gautier M., Nilsen H., Roseth A., Berg P.R., Sundsaasen K.K., Svendsen M., Meuwissen T.H.E., Mapping of a milk production quantitative trait locus to a 420-kb region on bovine chromosome 6, Genetics 169 (2005) 275-283.
14. Pérez-Enciso M., Fine mapping of complex trait genes combining pedigree and linkage disequilibrium information: a Bayesian unified framework, Genetics 163 (2003) 1497-1510.
15. Sillanpää M.J., Arjas E., Bayesian mapping of multiple quantitative trait loci from incomplete inbred line cross data, Genetics 148 (1998) 1373-1388.