Interleukin-17 and Airway Inflammation: A Longitudinal Airway Biopsy Study After Lung Transplantation

Journal of Heart and Lung Transplantation

Volumn 26, Issue 7, 2007, Pages 669-674

  Snell, Gregory I ^a   Levvey, Bronwyn J ^a   Zheng, Ling ^a   Bailey, Michael ^b   Orsida, Bernadette ^a   Williams, Trevor J ^a   Kotsimbos, Tom C ^a  

^a MONASH UNIVERSITY   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN; EVEROLIMUS; INTERLEUKIN 17; PLACEBO; PREDNISOLONE; THYMOCYTE ANTIBODY;

ADULT; ARTICLE; BRONCHIECTASIS; BRONCHIOLITIS OBLITERANS; BRONCHOSCOPY; BRONCHUS BIOPSY; CELL COUNT; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYSTIC FIBROSIS; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS; DISEASE CLASSIFICATION; DOUBLE BLIND PROCEDURE; DRUG DOSE REDUCTION; DRUG DOSE TITRATION; DRUG EFFECT; EMPHYSEMA; FEMALE; FOLLOW UP; GRAFT SURVIVAL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; LAMINA PROPRIA; LEUKOPENIA; LUNG FIBROSIS; LUNG GRAFT REJECTION; LUNG LAVAGE; LUNG TRANSPLANTATION; LYMPHOCYTE COUNT; MALE; MULTIVARIATE ANALYSIS; OUTCOME ASSESSMENT; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFECTION; STATISTICAL SIGNIFICANCE; THROMBOCYTOPENIA; UNIVARIATE ANALYSIS;

AZATHIOPRINE; BIOPSY; BRONCHOALVEOLAR LAVAGE; CD4-POSITIVE T-LYMPHOCYTES; DOUBLE-BLIND METHOD; FEMALE; GENE EXPRESSION REGULATION; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-17; LUNG; LUNG TRANSPLANTATION; MALE; MIDDLE AGED; PNEUMONIA; PROSPECTIVE STUDIES; SIROLIMUS;

EID: 34347233404     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.healun.2007.05.004     Document Type: Article

References (28)

1. Estenne M., Maurer J.R., Boehler A., et al. Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria. J Heart Lung Transplant 21 (2002) 297-310
2. Zheng L., Walters E.H., Ward C., et al. Airway neutrophilia in stable and bronchiolitis obliterans syndrome patients following lung transplant. Thorax 55 (2000) 53-60
3. Linden A., Laan M., and Anderson G.P. Neutrophils, interleukin 17A and lung disease. Eur Respir J 25 (2005) 159-172
4. Yao Z., Painter S.L., Fanslow W.C., et al. Human IL-17: a novel cytokine derived from T cells. J Immunol 155 (1995) 5483-5486
5. Miyamoto M., Prause O., Laan M., Sjostrand M., Lotvall J., and Linden A. Endogenous IL-17 mediates endotoxin induced airway neutrophilia in mice in-vitro. J Immunol (2003) 4665-4672
6. Yoshida S., Haque A., Mizobuchi T., et al. Anti-type V collagen lymphocytes that express IL-17 and IL-23 induce rejection pathology in fresh and well-healed lung transplants. Am J Transplant 6 (2006) 724-735
7. Vanaudenaerde B.M., Dupont L.J., Wuyts W.A., et al. The role of IL-17 during acute rejection after lung transplantation. Eur Respir J 27 (2006) 779-787
8. Loong C.C., Hsieh H.G., Lui W.Y., Chen A., and Lin C.Y. Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection. J Pathol 197 (2002) 322-332
9. Dong C. Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nature Rev 6 (2006) 329-333
10. Wuyts W.A., Vanuadenaerde B.M., Dupont L.J., et al. Interleukin-17-induced interleukin-8 release in human airway smooth muscle cells: role for mitogen-activated kinases and nuclear factor-kappa B. J Heart Lung Transplant 24 (2005) 875-881
11. Laan M., Palmberg L., Larsson K., and Linden A. Free, soluble interleukin-17 protein during severe inflammation in human airways. Eur Respir J 19 (2002) 534-537
12. Molet S., Hamid Q.A., Davoine F., et al. Interleukin-17 is increased in asthmatic airways and induces human fibroblasts to produce cytokines. J Allergy Clin Immunol 108 (2001) 103-109
13. Bergeron C., Alkerithy M., Kotsimbos T.C., and Hamid Q. Role of profibrotic cytokines IL-17 and IL-11 in chronic rejection following lung transplantation. [abstract]. J Heart Lung Transplant 25 suppl (2006) S83
14. Vanaudenaerde B., Wuyts W., Dupont L.J., Van Raemdonck D., Demedts M.M., and Verleden G.M. IL-17 stimulates release of IL8 by human airway smooth muscle cells in vitro: a potential role for IL17 and airway smooth muscle cells in bronchiolitis obliterans syndrome. J Heart Lung Transplant 22 (2003) 1280-1283
15. Snell G.I., Valentine V.G., Vitulo P., et al. Everolimus versus azathioprine as adjunctive therapy to inhibit the lung function decline in stable lung transplant recipients: 12- and 24-month results of an international, randomized, double-blind study. Am J Transplant 6 (2006) 169-177
16. Snell G., Levvey B.J., Zheng L., et al. Everolimus alters the bronchoalveolar lavage and endobronchial biopsy immunologic profile post human lung transplantation. Am J Transplant 5 (2005) 1446-1451
17. Gabbay E., Griffiths A., McFarlane L., et al. Maximizing the utilisation of donor organs offered for lung transplantation. Am J Respir Crit Care Med 160 (1999) 265-272
18. Chakinala M.M., and Trulock E.P. Acute allograft rejection after lung transplantation: diagnosis and therapy. Chest Surg Clin N Am 13 (2003) 525-531
19. Snell G.I., Hall M., Esmore D.S., and Williams T.J. Cytolytic therapy for obliterative bronchiolitis complicating lung transplantation. Chest 109 (1996) 874-879
20. Snell G.I., Ward C., Wilson J.W., Williams T.J., and Walters E.H. Immunopathology of the airway in stable lung transplant recipients. Thorax 52 (1997) 322-328
21. Antonysamy M.A., Fanslow W.C., Fu F., et al. Evidence for a role of IL-17 in organ allograft rejection: IL-17 promotes the functional differentiation of dendritic cell progenitors. J Immunol 162 (1999) 577-584
22. Kehlen A., Thiele K., Riemann D., and Langner J. Expression, modulation and signalling of IL17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis. Clin Exp Immunol 127 (2002) 539-546
23. Zheng L., Whitford H.M., Orsida B., et al. The dynamics and associations of airway neutrophilia post lung transplantation. Am J Transplant 6 (2006) 509-518
24. Tang J.-L., Subbotin V.M., Antonysamy M.A., Troutt A.B., Rao A.S., and Thomson A.W. Interleukin-17 antagonism inhibits acute but not chronic vascular rejection. Transplantation 72 (2001) 348-350
25. Barzyk A., Pierzcha W., and Sozanska E. Interleukin-17 in sputum correlates with airway responsiveness to methacholine. Respir Med 97 (2003) 726-773
26. Zheng L., Orsida B., Whitford H., et al. Longitudinal comparisons of lymphocytes and sub-types between airway wall and bronchoalveolar lavage after human lung transplantation. Transplantation 80 (2005) 185-193
27. Bueno V., and Pestana J.O.M. The role of CD8+ T cells in allograft rejection. Braz J Med Biol Res 35 (2002) 1247-1258
28. Yao Z., Spriggs M., Derry J., et al. Molecular characterisation of the human interleukin-17 receptor. Cytokine 9 (1997) 794-800