Glutamate production by HIV-1 infected human macrophage is blocked by the inhibition of glutaminase

Journal of Neurochemistry

Volumn 102, Issue 2, 2007, Pages 539-549

  Erdmann, Nathan ^a,b   Zhao, Jianxing ^a,b   Lopez, Alicia L ^a,b   Herek, Shelley ^a,b   Curthoys, Norman ^c   Hexum, Terry D ^b   Tsukamoto, Takashi ^d   Ferraris, Dana ^d   Zheng, Jialin ^a,b,e  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c Department of Environmental and Radiological Health Sciences   (United States)

^d MGI Pharma   (United States)

^e NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Glutamate; Glutaminase; HIV 1 associated dementia; Macrophages

Indexed keywords

BRAIN ENZYME; ENZYME INHIBITOR; GLUTAMIC ACID; GLUTAMINASE; GLUTAMINASE INHIBITOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

AMINO ACID SYNTHESIS; ARTICLE; BRAIN; CELL VIABILITY; CONTROLLED STUDY; DEMENTIA; DRUG DETERMINATION; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VITRO STUDY; KINETICS; MACROPHAGE FUNCTION; MONOCYTE; PRIORITY JOURNAL; VALIDATION PROCESS;

AIDS DEMENTIA COMPLEX; BIOLOGICAL ASSAY; CELL SURVIVAL; CELLS, CULTURED; ENZYME INHIBITORS; GLUTAMIC ACID; GLUTAMINASE; HIV-1; HUMANS; MACROPHAGES; RNA, SMALL INTERFERING;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RATTUS;

EID: 34347225166     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.04594.x     Document Type: Article

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