Effect of alkylcarbonates of γ-cyclodextrins with different chain lengths on drug complexation and release characteristics

International Journal of Pharmaceutics

Volumn 339, Issue 1-2, 2007, Pages 197-204

  Cavalli, Roberta ^a   Trotta, Francesco ^a   Trotta, Michele ^a   Pastero, Linda ^a   Aquilano, Dino ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Alkylcarbonate cyclodextrins; DSC; Inclusion complexes; Release rate; XRPD

Indexed keywords

ALKYL GROUP; CARBONIC ACID; DEXAMETHASONE; DIAZEPAM; FLURBIPROFEN; GAMMA CYCLODEXTRIN DERIVATIVE; PROGESTERONE;

ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG MANUFACTURE; DRUG RELEASE; DRUG SOLUBILITY; MELTING POINT; PRIORITY JOURNAL; X RAY POWDER DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; DRUG COMPOUNDING; GAMMA-CYCLODEXTRINS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; X-RAY DIFFRACTION;

EID: 34250894522     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2007.03.001     Document Type: Article

References (16)

1. Duchêne, D., 1987. Cyclodextrins and their Industrial Uses, De Santè Paris.
2. Gajewska M., Sznitoska M., and Janick S. Diazepam submicronemulsion containing soya-bean oil and intended for oral or rectal delivery. Pharmazie 56 (2001) 200-222
3. Harata K., Uekama K., Otagiri M., and Hirayama F. Crystal structure of permethylated cyclodextrion complexes with R-(-)-flurbiprofen and S-(+)-flurbiprofen. Chem. Lett. 9 (1984) 1549-1552
4. Higuchi T., and Connors K. Phase solubility techniques. Adv. Anal. Chem. Instrum. 4 (1965) 117-212
5. Irie T., and Uekama K. Pharmaceutical application of cyclodextrins III. Tossicological issues and safety evaluation. J. Pharm. Sci. 86 (1997) 147-162
6. Liu F., Kildsing D.O., and Mitra A.K. Complexation of 6-acyl-o-beta cyclodextrin derivatives with steroids- effects of chains length and substitution degree. Drug. Dev. Ind. Pharm. 18 (1992) 1599-1612
7. Loftsson T., and Brewster M.E. Pharmaceutical application of cyclodextrins I. Drug solubilization and stabilization. J. Pharm. Sci. 85 (1996) 1017-1025
8. Shimpi S., Chauhan B., and Shimpi P. Cyclodextrins: application in different routes of drug administration. Acta Pharm. 55 (2005) 139-156
9. Szente L., Szejtli J., and Kis G.I. Spontaneous opalescence of aqueous γ-cyclodextrin solutions: complex formation or self aggregation. J. Pharm. Sci. 87 (1998) 778-781
10. Thompson D.O. Cyclodextrin-enabling excipients: their present and future use in pharmaceuticals. Crit. Rev. Therap. Drug Carrier Syst. 14 (1997) 1-14
11. Trotta F., Moraglio G., Garzona M., and Maritano S. Acyclic carbonates of β cyclodextrin. Gazz. Chim. It. 123 (1993) 559-562
12. Trotta F., Cavalli R., and Trotta M. Investigation of hemolitic and complexation properties of γ-cyclodextrin carbonate derivatives. J. Incl. Phenom. Macroc. Chem. 44 (2002) 345-346
13. Uekama K., Hirayama F., and Irie T. Cyclodextrin drug carrier systems. Chem. Rev. 98 (1998) 2045-2076
14. Uekama K., Fujinaga T., Hirayama F., Otagiri M., and Yamasaki M. Inclusion complexation of steroid hormones with cyclodextrins in water and in solid phase. Int. J. Pharm. 10 (1982) 1-15
15. Zia V., Rajewski R.A., and Stella V.J. Thermodynamics of binding of neutral molecules to sulfobutylether β-cyclodextrin: the effect of the total degree of substitution. Pharm. Res. 17 (2000) 936-941
16. Zsadon B., Otta H., and Tudos F. Separation of cyclodextrins by high performance liquid chromatography. J. Chromatogr. 172 (1979) 490-492