α1-Adrenergic Receptors Augment P2X3 Receptor-Mediated Nociceptive Responses in the Uninjured State

Journal of Pain

Volumn 8, Issue 7, 2007, Pages 556-562

  Meisner, Jason G ^a   Waldron, James B ^a   Sawynok, Jana ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

1 adrenergic receptors; nociception; P2X3 receptors

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADRENALIN; ALPHA 1 ADRENERGIC RECEPTOR; BRIMONIDINE; CARBENE; CLONIDINE; PHENYLEPHRINE; PRAZOSIN; PROPRANOLOL; PURINE P2X3 RECEPTOR; TERAZOSIN; TIMOLOL; YOHIMBINE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; DRUG DERIVATIVE; PURINE P2 RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; DRUG MECHANISM; HYPERALGESIA; LOW DRUG DOSE; MALE; NOCICEPTION; NONHUMAN; PAIN ASSESSMENT; RAT; SENSORY NERVE; THERMAL ANALYSIS; ANIMAL; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; DRUG INTERACTION; DRUG POTENTIATION; FOOT; METABOLISM; NOCICEPTIVE RECEPTOR; PAIN; PATHOPHYSIOLOGY; PHYSIOLOGY; SENSORY RECEPTOR; SPRAGUE DAWLEY RAT; SYMPATHETIC NERVE;

ADENOSINE TRIPHOSPHATE; ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; DRUG INTERACTIONS; DRUG SYNERGISM; FOOT; HYPERALGESIA; MALE; NOCICEPTORS; PAIN; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, PURINERGIC P2; RECEPTORS, SENSORY; SYMPATHETIC FIBERS, POSTGANGLIONIC;

EID: 34250879149     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2007.02.434     Document Type: Article

References (49)

1. 1 antinociception, tolerance, and withdrawal. J Neurosci 17 (1997) 735-744
2. Banik R.K., Sato J., Yajima H., and Mizumura K. Differences between the Lewis and Sprague-Dawley rats in chronic inflammation induced norepinephrine sensitivity of cutaneous C-fiber nociceptors. Neurosci Lett 299 (2001) 21-24
3. Bland-Ward P.A., and Humphrey P.P.A. Acute nociception mediated by hindpaw P2X receptor activation in the rat. Br J Pharmacol 122 (1997) 365-371
4. 3 purinoreceptors in sensory neurons: Effects of axotomy and glial-derived neurotrophic factor. Mol Cell Neurosci 12 (1998) 256-268
5. Burnstock G. Noradrenaline and ATP: Cotransmitters and neuromodulators. J Physiol Pharmacol 46 (1995) 365-384
6. Chen Y., Li G.W., Wang C., Gu Y., and Huang L.Y.M. Mechanisms underlying enhanced P2X receptor-mediated responses in the neuropathic pain state. Pain 119 (2005) 38-48
7. 2-adrenergic receptor subtypes gene expression in rat dorsal root ganglion in an experimental model of neuropathic pain. NeuroReport 8 (1997) 3119-3122
8. Gold M.S., Dastmalchi S., and Levine J.D. α-Adrenergic receptor subtypes in rat dorsal root and superior cervical ganglion neurons. Pain 69 (1997) 179-190
9. Guo A., Vulchanova L., Wang J., Li X., and Elde R. Immunocytochemical localization of the vanilloid receptor 1 (VR1): Relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites. Eur J Neurosci 11 (1999) 946-958
10. Hamilton S.G., McMahon S.B., and Lewin C.R. Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin. J Physiol 543.2 (2001) 437-445
11. Hamilton S.G., Wade A., and McMahon S.B. The effects of inflammation and inflammatory mediators on nociceptive behaviour induced by ATP analogues in the rat. Br J Pharmacol 126 (1999) 326-332
12. Jänig W., and Häbler H.J. Sympathetic nervous system: contribution to chronic pain. Brain Res 129 (2000) 451-468
13. Jarvis M.F. Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain. Expert Opin Ther Targets 7 (2003) 513-522
14. Kage K., Niforatos W., Zhu C.Z., Lynch K.L., Honore P., and Jarvis M. Alteration of dorsal root ganglion P2X3 receptor expression and function following spinal nerve ligation in the rat. Exp Brain Res 147 (2002) 511-519
15. Kennedy C., Assis T.S., Currie A.J., and Rowan E.G. Crossing the pain barrier: P2 receptors as targets for novel analgesics. J Physiol 553.3 (2003) 683-694
16. Kennedy C. P2X receptors: targets for novel analgesics?. Neuroscientist 11 (2005) 345-356
17. 2-adrenergic receptor agonists in the rat. Neuroscience 66 (1995) 427-432
18. Khasar S.G., McCarter G., and Levine J.D. Epinephrine produces a β-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors. J Neurophysiol 81 (1999) 1104-1112
19. Kim C., Chung J.M., and Chung K. Changes in the gene expression of six subtypes of P2X receptors in rat dorsal root ganglion after spinal nerve ligation. Neurosci Lett 337 (2003) 81-84
20. Kinnman E., and Levine J.D. Involvement of the sympathetic postganglionic neuron in capsaicin-induced secondary hyperalgesia in the rat. Neuroscience 65 (1995) 283-291
21. 1-adrenoceptor pharmacology. Pharmacol Therapeutic 98 (2003) 235-244
22. Lee D.H., Liu X., Kim H.T., Chung K., and Chung J.M. Receptor subtype mediating the adrenergic sensitivity of pain behavior and ectopic discharges in neuropathic Lewis rats. J Neurophysiol 81 (1999) 2226-2233
23. Levine J.D., Taiwo Y.O., Collins S.D., and Tam J.K. Noradrenaline hyperalgesia is mediated through interaction with sympathetic postganglionic neurone terminals rather than activation of primary afferent nociceptors. Nature 323 (1986) 158-160
24. Lewin G.R., Ritter A.M., and Mendell L.M. Nerve growth factor-induced hyperalgesia in the neonatal and adult rat. J Neurosci 13 (1993) 2136-2148
25. Lin Q., Zou X., Fang L., and Willis W.D. Sympathetic modulation of acute cutaneous flare induced by intradermal injection of capsaicin in anesthetized rats. J Neurophysiol 89 (2003) 853-861
26. Maruo K., Yamamoto H., Yamamoto S., Nagata T., Fujokawa H., Kanno T., Yaguchi T., Mario S., Yoshiya S., and Nishizaki T. Modulation of P2X receptors via adrenergic pathways in rat dorsal root ganglion neurons after sciatic nerve injury. Pain 120 (2006) 106-112
27. McGaraughty S., and Jarvis M.F. Antinociceptive properties of a selective non-nucleotide P2X3/P2X2/3 receptor antagonist. Drug News Perspect 19 (2005) 501-507
28. Moon D.E., Lee D.H., Han H.C., Xie J., Coggeshall R.E., and Chung J.M. Adrenergic sensitivity of the rat sensory receptors modulating mechanical allodynia in a rat neuropathic pain model. Pain 80 (1999) 589-595
29. 3 subunit: A molecular target in pain therapeutics. Curr Opin Investig Drugs 4 (2003) 833-840
30. Ouseph A.K., and Levine J.D. Alpha 1-adrenoceptor-mediated sympathetically dependent mechanical hyperalgesia in the rat. Eur J Pharmacol 273 (1995) 107-112
31. Park S.K., Chung K., and Chung J.M. Effects of purinergic and adrenergic antagonists in a rat model of painful peripheral neuropathy. Pain 87 (2000) 171-179
32. 3 subunit. J Biol Chem 276 (2001) 21077-21082
33. Pieribone V.A., Nicholas A.P., Dagerlind A., and Hökfelt T. Distribution of alpha-1 adrenoceptors in rat brain revealed by in situ hybridization experiments utilizing subtype specific probes. J Neurosci 14 (1994) 4252-4268
34. Premkumar L.S., and Ahern G.P. Induction of vanilloid receptor channel activity by protein kinase C. Nature 408 (2000) 985-990
35. 3 expression in sensory neurons. J Neurochem 77 (2001) 864-875
36. Ren Y., Zou X., and Lin Q. Sympathetic modulation of activity in Aδ- and C-primary nociceptive afferents after intradermal injection of capsaicin in rats. J Neurophysiol 93 (2005) 365-377
37. Sato J., and Perl E.R. Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury. Science 251 (1991) 1608-1610
38. 2-adrenoceptors in rat dorsal root ganglia. Pain 84 (2000) 319-330
39. Teassell R.W., and Arnold J.M.O. Alpha-1 adrenoceptor hyperresponsiveness in three neuropathic pain states: Complex regional pain syndrome, diabetic peripheral neuropathic pain and central pain states after spinal cord injury. Pain Res Manage 9 (2004) 89-97
40. 2-adrenoreceptors on post-ganglionic sympathetic terminals. Pain 60 (1995) 317-327
41. 2/3 receptor signaling in capsaicin-insensitive primary afferent neurons. J Neurosci 20 (2000) 1-5 RC90
42. 3 mRNA expression by peripheral nerve injury in intact and injured neurons in the rat sensory ganglia. Pain 91 (2001) 351-360
43. Tuttle J.B., Etheridge R., and Creedon D.J. Receptor-mediated stimulation and inhibition of nerve growth factor secretion by vascular smooth muscle. Exp Cell Res 208 (1993) 350-361
44. Vellani V., Mapplebeck S., Moriondo A., Davis J.B., and McNaughton P.A. Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. J Physiol 534 (2001) 813-825
45. Waldron J.B., and Sawynok J. Peripheral P2X receptors and nociception: Interactions with biogenic amine systems. Pain 110 (2004) 79-89
46. Xie J., Lee Y.H., Wang C., Chung J.M., and Chung K. Differential expression of alpha1-adrenergic subtype mRNAs in the dorsal root ganglion after spinal nerve ligation. Mol Brain Res 93 (2001) 164-172
47. Xu G.Y., and Huang L.Y.M. Peripheral inflammation sensitizes P2X receptor-mediated responses in rat dorsal root ganglion neurons. J Neurosci 22 (2002) 93-102
48. 2+/calmodulin-dependent protein kinase II potentiates ATP responses by promoting trafficking of P2X receptors. Proc Natl Acad Sci U S A 101 (2004) 11868-11873
49. Zhou J., Chung K., and Chung J.M. Development of purinergic sensitivity in sensory neurons after peripheral nerve injury in the rat. Brain Res 915 (2001) 161-169